(Q27860694)

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Protein modules and signalling networks

scientific article (publication date: 16 February 1995)

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Europe PubMed Central

Protein modules and signalling networks (English)

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T Pawson

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16 February 1995

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373

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6515

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573-80

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A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

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A novel viral oncogene with structural similarity to phospholipase C

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Molecular cloning and expression of the major protein kinase C substrate of platelets

1 reference

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7 January 2021

based on heuristic

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SH2 and SH3 domains

1 reference

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7 January 2021

based on heuristic

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Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

1 reference

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Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1 reference

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

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Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding

1 reference

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7 January 2021

based on heuristic

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SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

1 reference

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based on heuristic

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

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Identification of a ten-amino acid proline-rich SH3 binding site

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

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Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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A putative modular domain present in diverse signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Pleckstrin domain homology

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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The PH domain: a common piece in the structural patchwork of signalling proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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More meanders and sandwiches

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Crystal structure of the pleckstrin homology domain from dynamin

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

G protein-coupled receptor kinases

1 reference

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7 January 2021

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Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1 reference

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7 January 2021

based on heuristic

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The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells

1 reference

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7 January 2021

based on heuristic

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Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

1 reference

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based on heuristic

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1 reference

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based on heuristic

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

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7 January 2021

based on heuristic

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

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7 January 2021

based on heuristic

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Antigen receptor tail clue.

1 reference

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7 January 2021

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T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

1 reference

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7 January 2021

based on heuristic

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

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7 January 2021

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

1 reference

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7 January 2021

based on heuristic

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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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The alphas, betas, and kinases of cytokine receptor complexes

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

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Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

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A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

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7 January 2021

based on heuristic

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteins regulating Ras and its relatives

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of p21 ras upon T-cell activation

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Association between GTPase activators for Rho and Ras families.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation and function of the Rho subfamily of small GTPases

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Association between the PDGF receptor and members of the src family of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A mitotic function for Src?

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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A target for Src in mitosis.

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

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Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

SH3 domains direct cellular localization of signaling molecules

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

SH3-dependent assembly of the phagocyte NADPH oxidase

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

The LIM domain is a modular protein-binding interface

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A repeating amino acid motif shared by proteins with diverse cellular roles

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Notch: neurogenesis is only part of the picture

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Abl kinase regulates the protein binding activity of c-Crk

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1 reference

https://api.crossref.org/works/10.1038%2F373573A0

7 January 2021

based on heuristic

inferred from DOI database lookup

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