(Q27681200)

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Rajendra Singh

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Stefanie Homann

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John Guatelli

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Yong Xiong

Nature Structural & Molecular Biology

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publication date

17 June 2012

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published in

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volume

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issue

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page(s)

701-6

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cites work

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A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex

20 March 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

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20 March 2017

A short history of SHELX

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Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

20 March 2017

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Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

20 March 2017

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Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes

20 March 2017

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Structure--function relationships in HIV-1 Nef.

20 March 2017

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Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions

20 March 2017

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A structural explanation for the recognition of tyrosine-based endocytotic signals

20 March 2017

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

20 March 2017

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

20 March 2017

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Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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SOLVE and RESOLVE: automated structure solution, density modification and model building

20 March 2017

1 reference

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An approach to multi-copy search in molecular replacement

20 March 2017

1 reference

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

20 March 2017

1 reference

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HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes

20 March 2017

1 reference

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Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif

20 March 2017

1 reference

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

20 March 2017

1 reference

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

20 March 2017

1 reference

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

20 March 2017

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Miscellaneous algorithms for density modification

20 March 2017

1 reference

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An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex

7 April 2017

1 reference

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Tickets to ride: selecting cargo for clathrin-regulated internalization.

29 September 2017

1 reference

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A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Role of Nef in primate lentiviral immunopathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Crystal structure of the clathrin adaptor protein 1 core

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Refined solution structure and backbone dynamics of HIV-1 Nef.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Biochemical dissection of AP-1 recruitment onto Golgi membranes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

2 June 2018

1 reference

The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail

21 January 2018

1 reference

Structural characterisation and functional significance of transient protein-protein interactions

21 January 2018

1 reference

Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain

21 January 2018

1 reference

The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1.

21 January 2018

1 reference

Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution

21 January 2018

1 reference

Clathrin-associated adaptor protein complexes

21 January 2018

1 reference

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

21 January 2018

1 reference

T7 vectors with modified T7lac promoter for expression of proteins in Escherichia coli

21 January 2018

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2328

1 reference

Dimensions Publication ID

1007255545

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1 reference

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PubMed publication ID

22705789

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