(Q24313754)

English

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

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The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3 (English)

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Forkhead box O1

1 reference

GOA release 2020-03-11

positive regulation of transcription, DNA-templated

1 reference

GOA release 2020-03-11

rhabdomyosarcoma

1 reference

based on heuristic

inferred from title

author name string

W J Fredericks

1

0 references

N Galili

2

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S Mukhopadhyay

3

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G Rovera

4

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J Bennicelli

5

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F G Barr

6

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F J Rauscher

7

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language of work or name

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publication date

March 1995

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Molecular and Cellular Biology

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15

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3

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1522-35

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EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

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The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

1 reference

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DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein

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Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

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Conservation of the paired domain in metazoans and its structure in three isolated human genes

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19 March 2017

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1 reference

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19 March 2017

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

1 reference

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19 March 2017

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

19 March 2017

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1 reference

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19 March 2017

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1 reference

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19 March 2017

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1 reference

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19 March 2017

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

19 March 2017

A frameshift mutation in the HuP2 paired domain of the probable human homolog of murine Pax-3 is responsible for Waardenburg syndrome type 1 in an Indonesian family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

19 March 2017

The human PAX6 gene is mutated in two patients with aniridia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

19 March 2017

Transcription activation by the adenovirus E1a protein

1 reference

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7 April 2017

Mouse small eye results from mutations in a paired-like homeobox-containing gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

7 April 2017

A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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The winged-helix DNA-binding motif: another helix-turn-helix takeoff

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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Acute promyelocytic leukemia: from genetics to treatment

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Molecular genetic aspects of human cancers: the 1993 Frank Rose Lecture

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Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina

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1 reference

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The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix

1 reference

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Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

The oncogenic potential of Pax genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Structure and DNA-binding properties of Pax-QNR, a paired box- and homeobox-containing gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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Molecular basis of splotch and Waardenburg Pax-3 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Cooperative dimerization of paired class homeo domains on DNA.

1 reference

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27 September 2017

Promoter-regulatory region of the major immediate early gene of human cytomegalovirus

1 reference

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Fos-associated protein p39 is the product of the jun proto-oncogene

1 reference

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27 September 2017

DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context

1 reference

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27 September 2017

Homeo boxes in the study of development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

A single amino acid can determine the DNA binding specificity of homeodomain proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Oncogenic conversion by regulatory changes in transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

What determines the specificity of action of Drosophila homeodomain proteins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Chromosome aberrations and cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Translocations, master genes, and differences between the origins of acute and chronic leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

The molecular basis of the undulated/Pax-1 mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Oncogenic conversion of transcription factors by chromosomal translocations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Pax in development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Molecular genetics of the Pax gene family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Pax genes, mutants and molecular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

Recognition of the surface of a homeo domain protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

27 September 2017

The homeodomain: a new face for the helix-turn-helix?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

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A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

A specific chromosomal abnormality in rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Divergent homeo box proteins recognize similar DNA sequences in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

N-CAM alterations in splotch neural tube defect mouse embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Localization of the rhabdomyosarcoma t(2;13) breakpoint on a physical map of chromosome 13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Small eye (Sey): Cloning and characterization of the murine homolog of the human aniridia gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Localization of the t(2;13) breakpoint of alveolar rhabdomyosarcoma on a physical map of chromosome 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

30 May 2018

1 reference

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29 November 2018

Regulation of Pax-3 expression in the dermomyotome and its role in muscle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

29 November 2018

Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230376

29 November 2018

Molecular and cytogenetic analysis of chromosomal arms 2q and 13q in alveolar rhabdomyosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the Pax-3 gene in the mouse mutant splotch

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consistent chromosomal translocation in alveolar rhabdomyosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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