(Q2071144)

Tumour necrosis factor-like domain superfamily

1 reference

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

CD40 receptor binding

1 reference

8 April 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

tumor necrosis factor receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

protein binding

1 reference

9 May 2019

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

integral component of plasma membrane

cell component

1 reference

9 May 2019

Human CD40‐ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

external side of plasma membrane

Ensembl genome database project

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

intracellular anatomical structure

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

leukocyte cell-cell adhesion

biological process

NAS

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of interleukin-12 production

NAS

1 reference

9 May 2019

Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

negative regulation of apoptotic process

1 reference

9 May 2019

CD40 Ligand Blocks Apoptosis Induced by Tumor Necrosis Factor α, Glucocorticoids, and Etoposide in Osteoblasts and the Osteocyte-Like Cell Line Murine Long Bone Osteocyte-Y4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

tumor necrosis factor-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

platelet activation

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of endothelial cell apoptotic process

1 reference

9 May 2019

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

B cell proliferation

1 reference

9 May 2019

Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

regulation of immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

1 reference

9 May 2019

B cell differentiation

Ensembl genome database project

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

inflammatory response

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

T cell costimulation

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of interleukin-4 production

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of interleukin-10 production

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

positive regulation of T cell proliferation

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

Tumour necrosis factor, conserved site

Gene Atlas image

PBB GE CD40LG 207892 at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

Tumour necrosis factor domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023