CD40 ligand (Q2071144)

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mammalian protein found in Homo sapiens

CD40 antigen ligand
TRAP
T-cell antigen Gp39
Tumor necrosis factor ligand superfamily member 5
T-B cell-activating molecule
CD40LG
TNF-related activation protein
tumor necrosis factor (ligand) superfamily member 5
CD40-L

Language	Label	Description	Also known as
English	CD40 ligand	mammalian protein found in Homo sapiens	CD40 antigen ligand TRAP T-cell antigen Gp39 Tumor necrosis factor ligand superfamily member 5 T-B cell-activating molecule CD40LG TNF-related activation protein tumor necrosis factor (ligand) superfamily member 5 CD40-L

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29965

Tumour necrosis factor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29965

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

CD40 receptor binding

determination method or standard

1 reference

8 April 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

tumor necrosis factor receptor binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

Human CD40‐ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

extracellular region

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

extracellular space

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

biological process

leukocyte cell-cell adhesion

determination method or standard

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-12 production

determination method or standard

1 reference

9 May 2019

Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

negative regulation of apoptotic process

determination method or standard

1 reference

9 May 2019

CD40 Ligand Blocks Apoptosis Induced by Tumor Necrosis Factor α, Glucocorticoids, and Etoposide in Osteoblasts and the Osteocyte-Like Cell Line Murine Long Bone Osteocyte-Y4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

platelet activation

determination method or standard

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of endothelial cell apoptotic process

determination method or standard

1 reference

9 May 2019

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

B cell proliferation

determination method or standard

1 reference

9 May 2019

Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

regulation of immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

B cell differentiation

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

inflammatory response

determination method or standard

1 reference

9 May 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

T cell costimulation

determination method or standard

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

9 May 2019

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-4 production

determination method or standard

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-10 production

determination method or standard

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

9 May 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29965

determination method or standard

Gene Atlas image

PBB GE CD40LG 207892 at fs.png
732 × 530; 12 KB

0 references

Tumour necrosis factor, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29965

Tumour necrosis factor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29965

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000359663

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000359663

ENSP00000359662

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000359662

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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