(Q14903821)

Dwarfin

1 reference

SMAD MH1 domain superfamily

1 reference

SMAD/FHA domain superfamily

1 reference

MAD homology, MH1, protein family

1 reference

based on heuristic

inferred from protein domain or family

SMAD domain, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAD homology 1, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

DNA-binding transcription factor activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Isl1Cre reveals a common Bmp pathway in heart and limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

1 reference

14 February 2019

protein binding

9 references

14 February 2019

Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

TAK1 is an essential regulator of BMP signalling in cartilage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

protein heterodimerization activity

1 reference

14 February 2019

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

sequence-specific DNA binding

1 reference

14 February 2019

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

primary miRNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

cell component

cytoplasm

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

intracellular anatomical structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340

1 reference

24 April 2018

nucleus

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

biological process

1 reference

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

ureteric bud development

1 reference

14 February 2019

Smad expression during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

1 reference

14 February 2019

SMAD protein signal transduction

1 reference

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

embryonic pattern specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

1 reference

14 February 2019

cellular response to organic cyclic compound

ISS

1 reference

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

hindbrain development

1 reference

14 February 2019

Smad1 and Smad8 function similarly in mammalian central nervous system development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

cardiac muscle cell proliferation

BMP signaling pathway

Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340

1 reference

24 April 2018

protein phosphorylation

1 reference

14 February 2019

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

gamete generation

1 reference

14 February 2019

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

cartilage development

1 reference

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

positive regulation of gene expression

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

positive regulation of cartilage development

1 reference

14 February 2019

miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

mesodermal cell fate commitment

1 reference

14 February 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

inflammatory response

1 reference

14 February 2019

Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

bone development

1 reference

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

transforming growth factor beta receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

1 reference

14 February 2019

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

midbrain development

1 reference

14 February 2019

Smad1 and Smad8 function similarly in mammalian central nervous system development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

negative regulation of cell population proliferation

1 reference

14 February 2019

Smad1 and Smad8 function similarly in mammalian central nervous system development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

positive regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Isl1Cre reveals a common Bmp pathway in heart and limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

14 February 2019

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

osteoblast fate commitment

1 reference

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

homeostatic process

1 reference

14 February 2019

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

cellular response to BMP stimulus

1 reference

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340

positive regulation of cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340

MAD homology 1, Dwarfin-type

has part(s)

1 reference

MAD homology, MH1

1 reference

SMAD domain, Dwarfin-type

1 reference