(Q64068166)

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Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

scientific article published on 03 May 2019

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28 April 2020

Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells (English)

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28 April 2020

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Chenkai Huang

1

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28 April 2020

Dakai Gan

2

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28 April 2020

Fangyun Luo

3

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28 April 2020

Sizhe Wan

4

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28 April 2020

Jiang Chen

5

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28 April 2020

Anjiang Wang

6

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28 April 2020

Bimin Li

7

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28 April 2020

Xuan Zhu

8

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28 April 2020

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3 May 2019

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28 April 2020

Frontiers in Pharmacology

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28 April 2020

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28 April 2020

431

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28 April 2020

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Creative Commons Attribution 4.0 International

3 May 2019

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Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats

1 reference

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12 December 2020

based on heuristic

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Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

1 reference

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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Effect of RhoA on transforming growth factor β1-induced rat hepatic stellate cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

1 reference

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12 December 2020

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The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis

1 reference

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12 December 2020

based on heuristic

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Role of NADPH oxidases in liver fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Hepatic stellate cells and liver fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species

1 reference

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12 December 2020

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The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway

1 reference

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Pulsed magnetic field accelerate proliferation and migration of cardiac microvascular endothelial cells

1 reference

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Collagen arrangement in space of Disse correlates with fluid flow in normal and cirrhotic rat livers

1 reference

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Pathobiology of liver fibrosis: a translational success story

1 reference

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Role of NADPH oxidases in the redox biology of liver fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

1 reference

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12 December 2020

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Overexpression of heparanase is associated with preeclampsia by inhibiting invasion of trophocytes

1 reference

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12 December 2020

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Nox/Duox Family of NADPH Oxidases: Lessons from Knockout Mouse Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Targeting hepatic macrophages to treat liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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American Gastroenterological Association Institute Technical Review on the Role of Elastography in Chronic Liver Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Ursolic acid suppresses TGF-β1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human hepatic stellate cell isolation and characterization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Determinants of fibrosis progression and regression in NASH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

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Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Acute compressive stress activates RHO/ROCK-mediated cellular processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

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Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.

1 reference

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The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin.

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Activation of human macrophages by human corneal allogen in vitro.

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microRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1.

1 reference

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LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma.

1 reference

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12 December 2020

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Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31130857

12 December 2020

based on heuristic

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Identifiers

10.3389/FPHAR.2019.00431

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31130857%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PMC publication ID

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Europe PubMed Central

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28 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31130857%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

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