(Q50851509)

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Toxicokinetics of organic solvents: a review of modifying factors

scientific article published in November 1998

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

1 reference

Europe PubMed Central

Toxicokinetics of organic solvents: a review of modifying factors (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

Gunnar Johanson

2

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

author name string

Löf A

1

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

language of work or name

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publication date

1 November 1998

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

Critical Reviews in Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

28

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

6

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

571-650

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

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Time-resolved cutaneous absorption and permeation rates of methanol in human volunteers

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Human cytochromes P-450.

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Acetone compared to other ketones in modifying the hepatotoxicity of inhaled 1,2-dichlorobenzene in rats and mice

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Evaluation of the interaction of benzene and toluene on the urinary excretion of t, t-muconic acid in rats

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Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study

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Covalent binding of styrene and styrene-7,8-oxide to plasma proteins, hemoglobin and DNA in the mouse

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Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,5-hexanedione

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Inhibition of the acute toxicity of methyl chloride in male B6C3F1 mice by glutathione depletion

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Drug pharmacokinetics in the obese

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The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction

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The effect of alcohols and toluene upon methylene chloride-induced carboxyhemoglobin in the rat and monkey

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Physiological changes due to age. Implications for drug therapy of congestive heart failure

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Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef

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Influence of aliphatic alcohols on the hepatic response to halogenated olefins

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Metabolic polymorphisms

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Influence of phenobarbital on xylene metabolism in man and rats

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Dichloroacetic acid and trichloroacetic acid increase chloroform toxicity

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Absorption, elimination and metabolism of trichloroethylene: a quantitative comparison between rats and mice

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Effects of acute exposure of toluene and methyl ethyl ketone on psychomotor performance

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Effects of short duration exposures to acetone and methyl ethyl ketone

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Acetone potentiation of acute acetonitrile toxicity in rats.

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Transcriptional control of CYP2E1 in the perivenous liver region and during starvation

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Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

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Distribution of urinary hippuric acid concentrations by ALDH2 genotype

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Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans.

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Effect of a single administration of benzene, toluene or m-xylene on carboxyhaemoglobin elevation and metabolism of dichloromethane in rats

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Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs

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Binding of drugs to serum albumin (first of two parts)

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Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

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Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid

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Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

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Biological rhythms in the absorption, distribution, metabolism and excretion of drugs

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Effects of pregnancy on the cytochrome P-450 system in mice

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Effect of ethanol on the metabolism of trichloroethylene

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Temporal variations in chloroform-induced hepatotoxicity in rats

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Pharmacokinetic interaction between benzene metabolites, phenol and hydroquinone, in B6C3F1 mice

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Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County

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Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa

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Interaction of DMSO and alcohol

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Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties

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Galactose elimination capacity and liver volume in aging man.

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Clinical pharmacokinetics in patients with liver disease

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Methanol poisoning I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole

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Recent developments in the study of the effects of cigarette smoking on clinical pharmacokinetics and clinical pharmacodynamics

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Polymorphism of aldehyde dehydrogenase and ethanol elimination

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Pharmacokinetics of trichloroethylene in volunteers, influence of workload and exposure concentration

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Circadian variations in trichloroethylene toxicity under a 12:12 hr light-dark cycle and their alterations under constant darkness in rats.

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P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

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Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol

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Dietary modification of metabolism and toxicity of chemical substances--with special reference to carbohydrate

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Effects of ethanol and phenobarbital administration on the metabolism and toxicity of benzene

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Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital

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Immunochemical characterization of cytochrome P-450 isozymes responsible for benzene oxidation in the rat liver

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Three forms of trichloroethylene-metabolizing enzymes in rat liver induced by ethanol, phenobarbital, and 3-methylcholanthrene

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Immunochemical detection of cytochrome P450 isozymes induced in rat liver byn-hexane, 2-hexanone and acetonyl acetone

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Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver

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Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Different Contributions of Cytochrome P450 2E1 and P450 2B1/2 to Chloroform Hepatotoxicity in Rat

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Acetaldehyde level in the blood and liver aldehyde dehydrogenase activities in trichloroethylene-treated rats.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The influence of n-hexane treatment on the glucuronic acid pathway and activity of some drug-metabolizing enzymes in guinea-pig

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Further studies on ketone neurotoxicity and interactions

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Effect of Age and Sex on Human Drug Metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Urinary excretion of hippuric acid and m-methylhippuric acid after administration of toluene and m-xylene mixture to rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Physical training and fasting erythrocyte activities of free radical scavenging enzyme systems in sedentary men.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Enzyme induction in the cytochrome P-450 system

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effect of dietary protein and fat on the activity of aryl hydrocarbon hydroxylase in rat liver, kidney and lung.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Action of styrene and its metabolites sytrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

A comparative study of the effects of benzene, toluene, and xylenes on their in vitro metabolism and drug-metabolizing enzymes in rat liver

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Urinary concentration, environmental concentration, and respiratory uptake of some solvents: effect of the work load.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Isopropanol and acetone potentiation of carbon tetrachloride‐induced hepatotoxic1ty: Single versus repetitive pretreatments in rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

1,4 Butanediol, gamma-hydroxybutyric acid and ethanol: relationships and interactions

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Methyl chloride and diazepam effects on performance

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Effect of chronic ethanol administration

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Cytochrome P450 isozyme induction by methyl ethyl ketone and m-xylene in rat liver

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effect of environmental factors on the pharmacokinetic behaviour of organic solvent vapours

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Dose-dependent metabolic interaction between benzene and toluene in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Interaction between ethanol and carbohydrate on the metabolism in rat liver of aromatic and chlorinated hydrocarbons

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Effects of chronic styrene inhalation on rat brain protein metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Biochemical effects of methyl tertiary-butyl ether in extended vapour exposure of rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Mechanism of percutaneous absorption. IV. Penetration of nonelectrolytes (alcohols) from aqueous solutions and from pure liquids.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Benzene and phenol metabolism by mouse and rat liver microsomes.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Hepatic drug metabolizing activity in lead-poisoned rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effect of diet on carbon tetrachloride metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Ethanol elimination among different racial groups

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Inhibition of mouse liver alcohol dehydrogenase by methyl N-butyl ketone

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Sex differences in the susceptibility of rats to carbon tetrachloride--alcohol-induced liver injury.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

An overview of benzene metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: evidence for an important role of microsomal epoxide hydrolase in the formation of hydr

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Diurnal rhythm of ethanol metabolism in the rat

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Paint-remover hazard

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Interactions between ethanol and other hepatotoxic agents

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Age affects the pharmacokinetics of inhaled anesthetics in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Acetone in diabetic ketoacidosis.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Individual variation in first-pass metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Assessment of occupational health risk from multiple exposure: review of industrial solvent interaction and implication for biological monitoring of exposure

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Ethanol induced modification of m-xylene toxicokinetics in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Studies on the regulation of glutathione level in rat liver

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: Gene deletion and its possible implications in alcohol metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The toxicity of methanol

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Metabolism of n-pentane by ethanol-inducible cytochrome P-450 in liver microsomes and reconstituted membranes

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Hepatic microsomal ethanol-oxidizing system (MEOS): metabolic aspects and clinical implications

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Differences in the potentiation of carbon tetrachloride in rats by ethanol and isopropanol pretreatment.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Chlorinated hydrocarbon toxicity. Potentiation by isopropyl alcohol and acetone.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Effect of 2-butanol and 2-butanone on rat hepatic ultrastructure and drug metabolizing enzyme activity

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Pharmacokinetics in the aged: A review

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Occupational exposure to solvent mixtures: effects on health and metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Biochemical and toxicological effects of combined exposure to 1,1,1-trichloroethane and trichloroethylene on rat liver and brain

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Adaptive changes caused by intermittent styrene inhalation on xenobiotic biotransformation

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Influence of exercise on the pharmacokinetics of drugs

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Aging and determinants of hepatic drug clearance

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Experimental human exposure to toluene. I. Factors influencing the individual respiratory uptake and elimination

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Plasma protein binding of drugs in the elderly

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Factors affecting drug binding in plasma of elderly patients

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effects of ethanol on the kinetics of toluene in man

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effects of ethanol on the kinetics of toluene in the perfused rat liver

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Influence of diet and nutritional status on drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Kinetic studies on toluene metabolism in ethanol- and phenobarbital-induced rat liver microsomes in vitro

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Dose- and route-dependent alteration of metabolism and toxicity of chloroform in fed and fasting rats

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Comparison of average estimated metabolic rates for styrene in previously exposed and unexposed groups with pharmacokinetic modelling

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Epinephrine-induced cardiac arrhythmias in rabbits exposed to trichloroethylene: Potentiation by ethanol

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Influence of cigarette smoking on the toxicokinetics of toluene in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Exposure to methyl isobutyl ketone: toxicokinetics and occurrence of irritative and CNS symptoms in man.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Dietary and ethanol induced alterations of the toxikokinetics of toluene in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Sex-Related Differences in Drug Disposition in Man

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Effects of combined exposure to trichloroethylene and alcohol on mental capacity

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Age-related changes in hepatic function. Implications for drug therapy

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

The effect of age upon liver volume and apparent liver blood flow in healthy man.

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Effects of alcohol on other hepatotoxins

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:Inhaled air concentration ratios

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinol

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

In vivo metabolic interactions of benzene and toluene

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Potentiation of 2,5-hexanedione neurotoxicity by methyl ethyl ketone*1, *2

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Interaction of alcohol with other drugs and nutrients. Implication for the therapy of alcoholic liver disease

1 reference

https://api.crossref.org/works/10.1080%2F10408449891344272

21 January 2018

Identifiers

10.1080/10408449891344272

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/9861527

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