(Q46809688)

25 December 2017

title

Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism (English)

1 reference

25 December 2017

1 reference

1 reference

Jens Christian Nielsen

object named as

Jens Christian Nielsen

Jens Nielsen

series ordinal

0 references

Jens B. Nielsen

object named as

Jens Christian Nielsen

Jens Nielsen

series ordinal

0 references

publication date

28 February 2017

1 reference

25 December 2017

Synthetic and systems biotechnology

published in

1 reference

25 December 2017

volume

1 reference

25 December 2017

issue

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25 December 2017

page(s)

5-12

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25 December 2017

Efficient gene editing in Neurospora crassa with CRISPR technology

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24 May 2018

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Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum

24 May 2018

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Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

24 May 2018

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Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

24 May 2018

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Transcriptomics-based strain optimization tool for designing secondary metabolite overproducing strains of Streptomyces coelicolor

24 May 2018

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Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

24 May 2018

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Computational approaches to natural product discovery

24 May 2018

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Minimum Information about a Biosynthetic Gene cluster.

24 May 2018

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A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi

24 May 2018

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IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites

24 May 2018

1 reference

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Computing the various pathways of penicillin synthesis and their molar yields

24 May 2018

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antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

24 May 2018

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Current state of genome-scale modeling in filamentous fungi

24 May 2018

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Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

24 May 2018

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Strain-level diversity of secondary metabolism in Streptomyces albus

24 May 2018

1 reference

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Production of natural products through metabolic engineering of Saccharomyces cerevisiae

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Microbial acetyl-CoA metabolism and metabolic engineering

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Synthetic biology for engineering acetyl coenzyme A metabolism in yeast

24 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome, Transcriptome, and Functional Analyses of Penicillium expansum Provide New Insights Into Secondary Metabolism and Pathogenicity

24 May 2018

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A roadmap for natural product discovery based on large-scale genomics and metabolomics

24 May 2018

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Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products

24 May 2018

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NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery

24 May 2018

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Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters

24 May 2018

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Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.

24 May 2018

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Automated genome mining of ribosomal peptide natural products

24 May 2018

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Overproduction of fatty acids in engineered Saccharomyces cerevisiae.

24 May 2018

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Motif-independent prediction of a secondary metabolism gene cluster using comparative genomics: application to sequenced genomes of Aspergillus and ten other filamentous fungal species

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

In silico tools for the analysis of antibiotic biosynthetic pathways

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

MIDDAS-M: motif-independent de novo detection of secondary metabolite gene clusters through the integration of genome sequencing and transcriptome data

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

MycoCosm portal: gearing up for 1000 fungal genomes.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Strategies for mining fungal natural products

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Elementary flux modes in a nutshell: properties, calculation and applications.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Regulation of fungal secondary metabolism

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

ClusterMine360: a database of microbial PKS/NRPS biosynthesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

24 May 2018

1 reference

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Computational tools for the synthetic design of biochemical pathways

24 May 2018

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A mass spectrometry-guided genome mining approach for natural product peptidogenomics

24 May 2018

1 reference

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Engineering strategy of yeast metabolism for higher alcohol production

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

A brief history of the antibiotic era: lessons learned and challenges for the future

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Fungal Indole Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway in Penicillium aethiopicum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Improved vanillin production in baker's yeast through in silico design

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

SMURF: Genomic mapping of fungal secondary metabolite clusters

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Use of genome-scale metabolic models for understanding microbial physiology

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Systems metabolic engineering: genome-scale models and beyond

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

A key role for vesicles in fungal secondary metabolism

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Biotechnological production and applications of statins

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Use of mycophenolic acid in non-transplant renal diseases

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Fungal secondary metabolism - from biochemistry to genomics

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Bioactive microbial metabolites

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-scale microbial in silico models: the constraints-based approach.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Engineering cofactor and transport mechanisms in Saccharomyces cerevisiae for enhanced acetyl-CoA and polyketide biosynthesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Improving polyketide and fatty acid synthesis by engineering of the yeast acetyl-CoA carboxylase.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2).

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Griseofulvin and its uses

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625732

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

15 August 2018

1 reference

12 December 2020

Small bugs, big business: the economic power of the microbe

1 reference

12 December 2020

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

1 reference

12 December 2020

Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine

1 reference

12 December 2020

The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production.

1 reference

12 December 2020

FunGeneClusterS: Predicting fungal gene clusters from genome and transcriptome data.

1 reference

12 December 2020

delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans

1 reference

12 December 2020

10.1016/J.SYNBIO.2017.02.002

Identifiers

DOI

1 reference

25 December 2017

PMC publication ID

5625732

1 reference

25 December 2017

PubMed publication ID

29062956

1 reference

25 December 2017