(Q46898268)

26 December 2017

title

COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis (English)

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26 December 2017

author name string

Gladson Muthian

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26 December 2017

Himanshu P Raikwar

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26 December 2017

Caroline Johnson

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26 December 2017

Johnson Rajasingh

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26 December 2017

Amit Kalgutkar

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26 December 2017

Lawrence J Marnett

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26 December 2017

John J Bright

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26 December 2017

publication date

1 January 2006

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26 December 2017

Journal of Clinical Immunology

published in

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26 December 2017

volume

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26 December 2017

issue

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26 December 2017

page(s)

73-85

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26 December 2017

Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes

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How many people in the world have multiple sclerosis?

21 January 2018

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Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

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Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)

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12 December 2020

Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis

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12 December 2020

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

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12 December 2020

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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12 December 2020

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

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12 December 2020

Mediation of inflammation by cyclooxygenase-2.

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12 December 2020

Cyclooxygenases 1 and 2

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12 December 2020

Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone

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12 December 2020

Cyclooxygenase in biology and disease

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12 December 2020

Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: an effect of the novel anti-inflammatory drug lisofylline

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Theories of the etiology of multiple sclerosis: a critical review

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12 December 2020

Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains

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12 December 2020

TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes

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12 December 2020

Animal models of demyelination

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12 December 2020

Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2

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12 December 2020

Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis

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12 December 2020

Animal models for autoimmune demyelinating disorders of the nervous system

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12 December 2020

Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

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Drugs in development for the treatment of multiple sclerosis: antigen non-specific therapies--an update

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Immunological aspects of demyelinating diseases

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An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.

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12 December 2020

The role of IL-12 in the induction of organ-specific autoimmune diseases

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Immunomodulatory drugs for multiple sclerosis: a systematic review of clinical and cost effectiveness

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12 December 2020

Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.

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12 December 2020

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

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12 December 2020

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

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12 December 2020

Mechanisms of immune injury in multiple sclerosis

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12 December 2020

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

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12 December 2020

Outcome of specific COX-2 inhibition in rheumatoid arthritis

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12 December 2020

Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis

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12 December 2020

Contingent genetic regulatory events in T lymphocyte activation

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12 December 2020

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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12 December 2020

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

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12 December 2020

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

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12 December 2020

Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis

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12 December 2020

Differential influence of interleukin-12 in the pathogenesis of autoimmune and virus-induced central nervous system demyelination.

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12 December 2020

Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis.

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12 December 2020

The effect of cyclooxygenase-2 inhibitor on experimental allergic neuritis

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12 December 2020

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

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12 December 2020

Forum: reactive species of peroxynitrite

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12 December 2020

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones.

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12 December 2020

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

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12 December 2020

Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation

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12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte

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12 December 2020

IL-12 augments antigen-dependent proliferation of activated T lymphocytes

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12 December 2020

Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

1 reference

12 December 2020

TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes.

1 reference

12 December 2020

10.1007/S10875-006-8787-Y

Identifiers

DOI

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26 December 2017

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26 December 2017