(Q55067922)

16 June 2018

review article

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title

Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents. (English)

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16 June 2018

author name string

Marnett LJ

series ordinal

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16 June 2018

Kalgutkar AS

series ordinal

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16 June 2018

publication date

1 August 1998

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16 June 2018

Current Opinion in Chemical Biology

published in

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16 June 2018

volume

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16 June 2018

issue

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16 June 2018

page(s)

482-490

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16 June 2018

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

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PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs

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7 January 2021

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

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7 January 2021

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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7 January 2021

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

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7 January 2021

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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7 January 2021

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

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7 January 2021

Human cyclooxygenase-2 cDNA

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7 January 2021

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

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7 January 2021

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

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7 January 2021

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

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7 January 2021

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

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7 January 2021

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

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7 January 2021

Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

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7 January 2021

Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction

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7 January 2021

Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX

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7 January 2021

Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385

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7 January 2021

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

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7 January 2021

Studies on antiinflammatory agents. II. Synthesis and pharmacological properties of 2'-(phenylthio)methanesulfonanilides and related derivatives

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7 January 2021

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents

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7 January 2021

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

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7 January 2021

Studies on Anti-inflammatory Agents. IV. Synthesis and Pharmacological Properties of 1,5-Diarylpyrazoles and Related Derivatives

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7 January 2021

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

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7 January 2021

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships

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7 January 2021

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents

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7 January 2021

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2

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7 January 2021

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

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7 January 2021

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

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7 January 2021

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

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7 January 2021

2,6-di-tert-butylphenols: a new class of potent and selective PGHS-2 inhibitor

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7 January 2021

Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity

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7 January 2021

Evaluation of Pharmacological Profile of Meloxicam as an Anti-Inflammatory Agent, with Particular Reference to Its Relative Selectivity for Cyclooxygenase-2 Over Cyclooxygenase-1

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7 January 2021

Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings

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7 January 2021

Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings

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7 January 2021

Acetylation of prostaglandin synthase by aspirin

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7 January 2021

Topographic studies of microsomal and pure prostaglandin H synthase

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7 January 2021

Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis

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7 January 2021

Protection of prostaglandin H synthase from trypsin upon binding of heme

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7 January 2021

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

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7 January 2021

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

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7 January 2021

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

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7 January 2021

Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

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7 January 2021

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

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7 January 2021

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

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7 January 2021

10.1016/S1367-5931(98)80124-5

Identifiers

DOI

1 reference

16 June 2018

1 reference

16 June 2018