(Q46709814)

24 December 2017

title

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells (English)

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24 December 2017

author name string

Ota H

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24 December 2017

Tokunaga E

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24 December 2017

Chang K

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24 December 2017

Hikasa M

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24 December 2017

Iijima K

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24 December 2017

Eto M

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24 December 2017

Kozaki K

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24 December 2017

Akishita M

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24 December 2017

Ouchi Y

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24 December 2017

Kaneki M

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24 December 2017

language of work or name

English

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publication date

1 January 2006

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24 December 2017

published in

Oncogene

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24 December 2017

volume

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24 December 2017

issue

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24 December 2017

page(s)

176-185

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24 December 2017

Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence

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Age dependent aneuploidy and telomere length of the human vascular endothelium

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

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Identification of a small molecule inhibitor of Sir2p

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The Sir2 family of protein deacetylases

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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7 January 2021

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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7 January 2021

Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours

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7 January 2021

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

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7 January 2021

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid

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7 January 2021

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

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7 January 2021

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

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7 January 2021

Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport

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7 January 2021

Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome

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7 January 2021

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

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7 January 2021

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

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7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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7 January 2021

The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells

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7 January 2021

Cellular senescence in cancer treatment: friend or foe?

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7 January 2021

Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells

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7 January 2021

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.

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7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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7 January 2021

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

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7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

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7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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7 January 2021

Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.

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7 January 2021

Cell senescence and cancer

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7 January 2021

Histone deacetylase inhibitors in psoriasis therapy

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7 January 2021

Mammalian SIRT1 represses forkhead transcription factors

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7 January 2021

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

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7 January 2021

A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Tumor senescence as a determinant of drug response in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Histone deacetylase inhibitors in clinical development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

1 reference

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7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Telomeres, stem cells, senescence, and cancer

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7 January 2021

Hallmarks of senescence in carcinogenesis and cancer therapy

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Targeted histone deacetylase inhibition for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Induction of senescent-like growth arrest as a new target in anticancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Retinoic Acid Inhibition of Cell Cycle Progression in MCF-7 Human Breast Cancer Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209049

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209049

1 reference

24 December 2017

Dimensions Publication ID

1006631278

0 references

1 reference

24 December 2017