(Q46544691)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

S Park

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

N Gallay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

L Willems

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

K M Shokat

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

N Azar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

F Viguié

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

F Dreyfus

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

P Mayeux

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

C Lacombe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

12 June 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

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8 January 2020

volume

1 reference

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8 January 2020

issue

1 reference

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8 January 2020

page(s)

1698-1706

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18548104%20AND%20SRC:MED&resulttype=core&format=json

Biology of normal and acute myeloid leukemia stem cells

8 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Survival of acute myeloid leukemia cells requires PI3 kinase activation

21 January 2018

1 reference

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Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

mTOR regulates cell survival after etoposide treatment in primary AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Antileukemic activity of rapamycin in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A quantitative analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

mTOR, a new therapeutic target in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A critical role for Lyn in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

Self-renewal writ in blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144

inferred from DOI database lookup

7 January 2021

based on heuristic

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.144