(Q40184405)

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

scientific article published on 11 January 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

multiple drug resistance

1 reference

based on heuristic

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based on heuristic

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author name string

P L Tazzari

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

A Cappellini

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

F Ricci

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

C Evangelisti

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

V Papa

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

T Grafone

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

G Martinelli

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

R Conte

8

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

L Cocco

9

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

J A McCubrey

10

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

A M Martelli

11

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

publication date

11 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

21

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Europe PubMed Central

PubMed publication ID

18 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

427-438

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Structure, regulation and function of PKB/AKT--a major therapeutic target

1 reference

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

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The molecular pathogenesis of acute myeloid leukemia

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Myeloproliferative disorders: premalignant, stem cell, G1 diseases?

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

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Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells

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The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

1 reference

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

1 reference

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Recent advances in understanding the cell death pathways activated by anticancer therapy

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Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.

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Transcriptional regulation of ABC drug transporters

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Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.

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Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies

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Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

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Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport

1 reference

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Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients

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Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia

1 reference

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Assessment of drug resistance in acute myeloid leukemia

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Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

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Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

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Comparative analysis of the effects of sample source and test methodology on the assessment of protein expression in acute myelogenous leukemia

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Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

1 reference

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Multidrug resistance protein (MRP) activity in normal mature leukocytes and CD34-positive hematopoietic cells from peripheral blood

1 reference

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7 January 2021

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Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

1 reference

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Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells.

1 reference

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Modulation of MDR/MRP by wild-type and mutant p53.

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Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer.

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Drug therapy for acute myeloid leukemia

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The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation

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The MRP family of drug efflux pumps

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The protein kinase B/Akt signalling pathway in human malignancy

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Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.

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Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.

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Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines

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10.1038/SJ.LEU.2404523

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

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