(Q45303597)

11 December 2017

title

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model (English)

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11 December 2017

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Christian Haass

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Armin Giese

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F Ulrich Hartl

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11 December 2017

Niclas W Schiffer

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11 December 2017

Sarah A Broadley

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11 December 2017

Thomas Hirschberger

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11 December 2017

Paul Tavan

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11 December 2017

Hans A Kretzschmar

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11 December 2017

Bettina Schmid

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11 December 2017

language of work or name

English

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publication date

14 December 2006

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Journal of Biological Chemistry

11 December 2017

published in

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11 December 2017

volume

282

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11 December 2017

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11 December 2017

page(s)

9195-9203

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Opinion: What is the role of protein aggregation in neurodegeneration?

11 December 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Games played by rogue proteins in prion disorders and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Characterization of the Huntington's disease (HD) gene homologue in the zebrafish Danio rerio.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

In vivo drug discovery in the zebrafish

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Stages of embryonic development of the zebrafish

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Zebrafish Hsp70 is required for embryonic lens formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Ground states of molecules. 38. The MNDO method. Approximations and parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

VMD: visual molecular dynamics

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607865200

Roles of molecular chaperones in protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Evidence for assembly of prions with left-handed beta-helices into trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Recent atomic models of amyloid fibril structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Casting an eye over cyclopia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

The calcium pump of the endoplasmic reticulum plays a role in midline signaling during early zebrafish development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Deranged neuronal calcium signaling and Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607865200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607865200

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11 December 2017

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