(Q45227245)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654602%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients (English)

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7 January 2020

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7 January 2020

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7 January 2020

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7 January 2020

M Anello

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7 January 2020

R Lupi

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7 January 2020

D Spampinato

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7 January 2020

M Masini

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7 January 2020

U Boggi

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7 January 2020

A M Rabuazzo

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7 January 2020

F Purrello

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7 January 2020

publication date

15 January 2005

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7 January 2020

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7 January 2020

volume

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7 January 2020

issue

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7 January 2020

page(s)

282-289

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

7 January 2020

cites work

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12 December 2020

Function of pancreatic islets isolated from a type 1 diabetic patient

1 reference

12 December 2020

The biology of mitochondrial uncoupling proteins

1 reference

12 December 2020

The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes.

1 reference

12 December 2020

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

1 reference

12 December 2020

Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation

1 reference

12 December 2020

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

12 December 2020

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance

1 reference

12 December 2020

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

1 reference

12 December 2020

Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets

1 reference

12 December 2020

Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio

1 reference

12 December 2020

Free fatty acids and type 2 diabetes mellitus

1 reference

12 December 2020

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

1 reference

12 December 2020

Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients

1 reference

12 December 2020

Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets

1 reference

12 December 2020

Morphologic basis for loss of regulated insulin secretion by isolated rat pancreatic islets

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12 December 2020

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

12 December 2020

Type 2 diabetes in children and adolescents. American Diabetes Association

1 reference

12 December 2020

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

1 reference

12 December 2020

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

12 December 2020

Oxidative stress and programmed cell death in diabetic neuropathy

1 reference

12 December 2020

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1 reference

12 December 2020

Triggering and amplifying pathways of regulation of insulin secretion by glucose

1 reference

12 December 2020

Insulin secretion in maturity-onset-diabetes. Function of isolated islets

1 reference

12 December 2020

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

1 reference

12 December 2020

Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines

1 reference

12 December 2020

Mitochondrial function in normal and diabetic beta-cells

1 reference

12 December 2020

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

1 reference

12 December 2020

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

1 reference

12 December 2020

Effects of high glucose on insulin secretion by isolated rat islets and purified beta-cells and possible role of glycosylation

1 reference

12 December 2020

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

1 reference

12 December 2020

Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47)

1 reference

12 December 2020

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study

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12 December 2020

Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

1 reference

12 December 2020

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

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12 December 2020

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

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12 December 2020

Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.

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12 December 2020

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells

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12 December 2020

Desensitization of the insulin‐secreting beta cell

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12 December 2020

Structural changes of mitochondria related to apoptosis

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12 December 2020

Free radical-induced megamitochondria formation and apoptosis.

1 reference

12 December 2020

The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets

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12 December 2020

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

1 reference

12 December 2020

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

1 reference

12 December 2020

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites

1 reference

12 December 2020

Stereological principles for morphometry in electron microscopic cytology

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12 December 2020

A radical explanation for glucose-induced beta cell dysfunction

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12 December 2020

Uncoupling protein 2 and islet function

1 reference

12 December 2020

Pathogenesis of NIDDM. A balanced overview

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12 December 2020

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group

1 reference

12 December 2020

Megamitochondria formation - physiology and pathology.

1 reference

12 December 2020

Effects of cryopreservation and coculture with pancreatic ductal epithelial cells on insulin secretion from human pancreatic islets

1 reference

12 December 2020

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

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12 December 2020

Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects

1 reference

12 December 2020

Uncoupling protein-2: evidence for its function as a metabolic regulator

1 reference

12 December 2020

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

1 reference

12 December 2020

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

1 reference

12 December 2020

10.1007/S00125-004-1627-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654602%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 January 2020

1023853273

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