(Q44722885)

5 December 2017

title

Modulation of amyloid precursor protein cleavage by cellular sphingolipids (English)

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5 December 2017

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Naoya Sawamura

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5 December 2017

Mihee Ko

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5 December 2017

Wenxin Yu

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5 December 2017

Kun Zou

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5 December 2017

Kentaro Hanada

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5 December 2017

Toshiharu Suzuki

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5 December 2017

Jian-Sheng Gong

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5 December 2017

Katsuhiko Yanagisawa

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5 December 2017

Makoto Michikawa

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5 December 2017

language of work or name

English

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publication date

10 January 2004

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Journal of Biological Chemistry

5 December 2017

published in

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5 December 2017

volume

279

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5 December 2017

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5 December 2017

page(s)

11984-11991

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Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

5 December 2017

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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

21 January 2018

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Cholesterol and Alzheimer's disease: is there a link?

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Cholesterol, A beta and Alzheimer's disease

21 January 2018

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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Functional rafts in cell membranes

21 January 2018

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Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

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The caveolae membrane system

21 January 2018

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Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes.

21 January 2018

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Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

21 January 2018

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COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

21 January 2018

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Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase

21 January 2018

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Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

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Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

21 January 2018

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Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

21 January 2018

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A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis

21 January 2018

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Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon

21 January 2018

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Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

21 January 2018

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Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin.

21 January 2018

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Lipid rafts and signal transduction

21 January 2018

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Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein

21 January 2018

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Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme

21 January 2018

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Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells.

21 January 2018

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Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

21 January 2018

1 reference

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A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity

21 January 2018

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Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

21 January 2018

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Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

21 January 2018

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

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Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

21 January 2018

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Inhibition of beta-amyloid production by activation of protein kinase C.

21 January 2018

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

21 January 2018

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Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

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The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

21 January 2018

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Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

21 January 2018

1 reference

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Fumonisin B1-induced Sphingolipid Depletion Inhibits Vitamin Uptake via the Glycosylphosphatidylinositol-anchored Folate Receptor

21 January 2018

1 reference

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Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309832200

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309832200

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309832200

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309832200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309832200

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pckmhgjpcrbpxfkdg4igrsqh24

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30 July 2022

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Fatcat ID

release_pckmhgjpcrbpxfkdg4igrsqh24

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Fatcat

https://api.fatcat.wiki/v0/release/pckmhgjpcrbpxfkdg4igrsqh24

mapped directly with Wikidata item

30 July 2022

based on heuristic

https://api.fatcat.wiki/v0/release/pckmhgjpcrbpxfkdg4igrsqh24

1 reference