(Q43812611)

27 November 2017

title

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis (English)

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27 November 2017

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Halasy-Nagy JM

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27 November 2017

Rodan GA

series ordinal

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27 November 2017

Reszka AA

series ordinal

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27 November 2017

language of work or name

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1 December 2001

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27 November 2017

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27 November 2017

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27 November 2017

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27 November 2017

page(s)

553-559

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The Rap1 GTPase functions as a regulator of morphogenesis in vivo

27 November 2017

cites work

1 reference

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7 January 2021

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Rho-A is critical for osteoclast podosome organization, motility, and bone resorption

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https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

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7 January 2021

Etidronate (EHDP) inhibits osteoclastic-bone resorption, promotes apoptosis and disrupts actin rings in isolate-mature osteoclasts.

1 reference

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7 January 2021

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

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7 January 2021

Reversibility of alendronate-induced contraction in human osteoclast-like cells formed from bone marrow cells in culture

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7 January 2021

Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)

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7 January 2021

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

PRK1 is targeted to endosomes by the small GTPase, RhoB

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https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

1 reference

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7 January 2021

Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.

1 reference

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7 January 2021

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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7 January 2021

Rac-GTPase, osteoclast cytoskeleton and bone resorption

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7 January 2021

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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7 January 2021

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

1 reference

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7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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7 January 2021

Relationship between bisphosphonate concentration and osteoclast activity and viability

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7 January 2021

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

1 reference

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7 January 2021

The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Structural requirements for bisphosphonate actions in vitro

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7 January 2021

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900615-9

7 January 2021

10.1016/S8756-3282(01)00615-9

Identifiers

DOI

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27 November 2017

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