(Q34793691)

English

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

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Europe PubMed Central

PubMed publication ID

4 August 2017

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

geranylgeraniol

1 reference

based on heuristic

inferred from title

author name string

Fisher JE

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Rogers MJ

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Halasy JM

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Luckman SP

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Hughes DE

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Masarachia PJ

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Wesolowski G

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Russell RG

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Rodan GA

9

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Reszka AA

10

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

0 references

publication date

1 January 1999

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

4 August 2017

96

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Europe PubMed Central

PubMed publication ID

4 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

133-138

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Role of Rab GTPases in membrane traffic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Novel Salvage Pathway Utilizing Farnesol and Geranylgeraniol for Protein Isoprenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Removal of osteoclast bone resorption products by transcytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Bisphosphonates: mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Molecular mechanisms of bone resorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Bisphosphonates act on rat bone resorption through the mediation of osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

Geranylgeranylated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15105

8 July 2018

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mad Bet for Rab

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for bisphosphonate actions in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and Characterization of Highly Enriched, Prefusion Mouse Osteoclastic Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.1.133

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1999PNAS...96..133F

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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