(Q42509261)

1 November 2017

title

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway (English)

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1 November 2017

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1 November 2017

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1 November 2017

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1 November 2017

Rosario Sanchez-Pernaute

object named as

Rosario Sanchez-Pernaute

José Manuel Bravo-San Pedro

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object named as

José M Bravo-San Pedro

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1 November 2017

author name string

Elisa Pizarro-Estrella

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1 November 2017

Ana Aiastui-Pujana

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1 November 2017

Ana Gorostidi

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1 November 2017

Vicente Climent

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1 November 2017

Rakel López de Maturana

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1 November 2017

Adolfo López de Munain

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1 November 2017

Rosa A González-Polo

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1 November 2017

publication date

8 July 2012

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Cellular and Molecular Life Sciences

1 November 2017

published in

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1 November 2017

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1 November 2017

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1 November 2017

page(s)

121-136

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Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

1 November 2017

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

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Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

21 January 2018

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

21 January 2018

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Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

21 January 2018

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

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LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

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Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.

21 January 2018

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Autophagy: dual roles in life and death?

21 January 2018

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The autophagosomal-lysosomal compartment in programmed cell death

21 January 2018

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Autophagy and the Integrated Stress Response

21 January 2018

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Autophagy in the eukaryotic cell

21 January 2018

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NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

21 January 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

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Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

21 January 2018

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Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells

21 January 2018

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A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1.

21 January 2018

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The IKK complex contributes to the induction of autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

21 January 2018

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

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Diagnostic criteria for Parkinson disease

21 January 2018

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Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

21 January 2018

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21 January 2018

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Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

21 January 2018

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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

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21 January 2018

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α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Interaction between α-synuclein and other proteins in neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

alpha-synuclein and LRRK2: partners in crime

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Alpha-synuclein and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Pathological roles of α-synuclein in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

21 January 2018

1 reference

12 December 2020

Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al

1 reference

12 December 2020

Autophagy and cancer therapy

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

10.1007/S00018-012-1061-Y

Identifiers

DOI

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1 November 2017

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