(Q39457004)

12 September 2017

title

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition (English)

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12 September 2017

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Elizabeth A Doggett

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12 September 2017

Jing Zhao

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12 September 2017

Christina N Mork

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12 September 2017

Dongmei Hu

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12 September 2017

R Jeremy Nichols

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12 September 2017

language of work or name

English

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publication date

11 November 2011

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Journal of Neurochemistry

12 September 2017

published in

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12 September 2017

volume

120

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12 September 2017

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12 September 2017

page(s)

37-45

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LRRK2 signaling pathways: the key to unlocking neurodegeneration?

12 September 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

21 January 2018

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Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

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Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Identification of the autophosphorylation sites of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

LRRK2 in Parkinson's disease: protein domains and functional insights

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07537.X

10.1111/J.1471-4159.2011.07537.X

21 January 2018

Identifiers

DOI

1 reference

12 September 2017

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