(Q41931960)

14 October 2017

Using multiple genetic variants as instrumental variables for modifiable risk factors (English)

1 reference

instrumental variables estimation

14 October 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21216802

21 November 2024

1 reference

14 October 2017

1 reference

14 October 2017

1 reference

14 October 2017

1 reference

14 October 2017

Roger M Harbord

0 references

Tom M Palmer

0 references

Nuala A Sheehan

0 references

Jonathan A C Sterne

1 reference

14 October 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21216802

21 November 2024

publication date

7 January 2011

1 reference

full work available at URL

14 October 2017

https://europepmc.org/articles/pmc3917707?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21216802

https://europepmc.org/articles/PMC3917707

21 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21216802

https://europepmc.org/articles/PMC3917707?pdf=render

21 November 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21216802

https://journals.sagepub.com/doi/pdf/10.1177/0962280210394459

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

https://journals.sagepub.com/doi/full-xml/10.1177/0962280210394459

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

Statistical Methods in Medical Research

21 November 2024

published in

1 reference

14 October 2017

1 reference

14 October 2017

1 reference

14 October 2017

223-242

1 reference

maintained by WikiProject

14 October 2017

WikiProject Mathematics

0 references

cites work

Mendelian Randomization for Strengthening Causal Inference in Observational Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mendelian randomization: nature's randomized trial in the post-genome era.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

How does body fat influence bone mass in childhood? A Mendelian randomization approach

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

The fat mass- and obesity-associated locus and dietary intake in children

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mendelian randomisation and causal inference in observational epidemiology

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Common variants near MC4R are associated with fat mass, weight and risk of obesity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Genome-wide association analysis identifies 20 loci that influence adult height

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mendelian randomization as an instrumental variable approach to causal inference

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

A new multipoint method for genome-wide association studies by imputation of genotypes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

A genome-wide association study identifies novel risk loci for type 2 diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Instruments for causal inference: an epidemiologist's dream?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Genetic signatures of strong recent positive selection at the lactase gene

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mendelian randomization: prospects, potentials, and limitations

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Natural selection and molecular evolution in PTC, a bitter-taste receptor gene

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Population stratification and spurious allelic association

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Association study designs for complex diseases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Distribution of ADH2 and ALDH2 genotypes in different populations.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Evaluating coverage of genome-wide association studies

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Commentary: the concept of 'Mendelian Randomization'.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917707

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

18 August 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

Specification Tests in Econometrics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

The Estimation of Economic Relationships using Instrumental Variables

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

Demonstrating stratification in a European American population

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

A Survey of Weak Instruments and Weak Identification in Generalized Method of Moments

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0962280210394459

Estimation of bias in nongenetic observational studies using "mendelian triangulation"

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21216802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21216802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of Causal Effects Using Instrumental Variables

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

Instrumental Variables and GMM: Estimation and Testing

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

Enhanced Routines for Instrumental Variables/Generalized Method of Moments Estimation and Testing

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

Large Sample Properties of Generalized Method of Moments Estimators

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

Problems with Instrumental Variables Estimation when the Correlation between the Instruments and the Endogenous Explanatory Variable is Weak

21 November 2024

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

21 November 2024

Davey Smith G

2010

1 reference

https://api.crossref.org/works/10.1177/0962280210394459

21 November 2024

Identifiers

1 reference

14 October 2017

1 reference

14 October 2017

1 reference