(Q40292772)

19 September 2017

title

Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. (English)

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19 September 2017

Jason A Gustin

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19 September 2017

Chandrashekhar K Korgaonkar

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19 September 2017

Roxana Pincheira

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19 September 2017

Qiutang Li

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19 September 2017

David B Donner

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19 September 2017

language of work or name

English

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publication date

12 April 2006

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

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19 September 2017

page(s)

16473-16481

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

19 September 2017

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21 January 2018

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21 January 2018

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Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

21 January 2018

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21 January 2018

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21 January 2018

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

21 January 2018

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

21 January 2018

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

21 January 2018

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Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation

21 January 2018

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21 January 2018

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21 January 2018

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Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase

21 January 2018

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21 January 2018

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Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

21 January 2018

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21 January 2018

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21 January 2018

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Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

21 January 2018

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

21 January 2018

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Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

21 January 2018

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

21 January 2018

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Signal transduction by the TCR for antigen

21 January 2018

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Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions

21 January 2018

1 reference

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Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival

21 January 2018

1 reference

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Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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Physiological functions of Pten in mouse tissues

21 January 2018

1 reference

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

21 January 2018

1 reference

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Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

21 January 2018

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

Akt is TCL-ish: implications for B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

AKT plays a central role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507373200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507373200

1 reference

19 September 2017

1 reference