(Q35571372)

8 August 2017

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title

Targeting the PI3K-Akt pathway in human cancer: rationale and promise (English)

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8 August 2017

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8 August 2017

Ji Luo

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8 August 2017

Brendan D Manning

series ordinal

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8 August 2017

publication date

1 October 2003

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8 August 2017

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

257-262

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Cyclin D1 in breast cancer

8 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Rules for making human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Physiological functions of Pten in mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

To cycle or not to cycle: a critical decision in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

c-MYC: more than just a matter of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Rapamycin in transplantation: a review of the evidence

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Smart drugs: tyrosine kinase inhibitors in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

PTEN and p53: who will get the upper hand?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Phosphoinositide 3-kinase-dependent activation of Rac.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

The role of nitric oxide in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900248-4

7 January 2021

10.1016/S1535-6108(03)00248-4

Identifiers

DOI

1 reference

8 August 2017

1 reference