(Q40017196)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

title

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Sanae Kourimate

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Cédric Le May

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Cédric Langhi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Anne Laure Jarnoux

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Khadija Ouguerram

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Yassine Zaïr

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Patrick Nguyen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Bertrand Cariou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Philippe Costet

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

language of work or name

English

0 references

publication date

3 February 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

2 January 2020

published in

1 reference

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2 January 2020

volume

283

1 reference

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2 January 2020

issue

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2 January 2020

page(s)

9666-9673

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

2 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Molecular biology of PCSK9: its role in LDL metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Rationale for targeting multiple lipid pathways for optimal cardiovascular risk reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

The proprotein convertases are potential targets in the treatment of dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Hepatic proprotein convertases modulate HDL metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Liver X receptors in cardiovascular and metabolic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

PCSK9: a promising therapeutic target for dyslipidemias?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

Peroxisome Proliferator-Activated Receptors Mediate Pleiotropic Actions of Statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705831200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705831200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18245819%20AND%20SRC:MED&resulttype=core&format=json