(Q34726862)

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The mechanisms of alloxan- and streptozotocin-induced diabetes

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1 reference

Europe PubMed Central

The mechanisms of alloxan- and streptozotocin-induced diabetes (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1 reference

ChEBI release 2020-05-28

author name string

Lenzen S

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

publication date

18 December 2007

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

51

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

216-226

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

https://scigraph.springernature.com/pub.10.1007/s00125-007-0886-7

0 references

Selective uptake of alloxan by pancreatic B-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

21 January 2018

Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose for protection against inhibition

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

21 January 2018

Effects of alloxan on the islets of Langerhans: inhibition of leucine metabolism and insulin secretion

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

21 January 2018

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

21 January 2018

Inhibition of rat liver glucokinase by alloxan and ninhydrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan Stimulation and Inhibition of Insulin Release from Isolated Rat Islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effects of alloxan on the metabolism and insulin secretion of the pancreatic B-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allopurinol protects pancreatic beta cells from the cytotoxic effect of streptozotocin: in vitro study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozotocin: depression of mouse liver pyridine nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucokinase in pancreatic B-cells and its inhibition by alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic uptake of [2-(14)C]alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mechanism of Cysteine and Glutathione Protection Against Alloxan Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLUT2 in Pancreatic Islets: Crucial Target Molecule in Diabetes Induced With Multiple Low Doses of Streptozotocin in Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevention of alloxan-induced diabetes in mice by the iron-chelator detapac: suggestion of a role for iron in the cytotoxic process

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan studies; the action of alloxan homologues and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of alloxan inhibition of glucose-induced insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drugs producing diabetes through damage of the insulin secreting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alkylation of DNA in rat tissues following administration of streptozotocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of O-linked protein glycosylation in beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular requirements for recognition at glucoreceptor for insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical antitumor activity and toxicity of streptozotocin (NSC-85998)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the accumulation of alloxan in the pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenging effect of melatonin on hydroxyl radicals generated by alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the diabetogenic action of streptozotocin (NSC-37917)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozocin: a review of its pharmacology, efficacy, and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan: history and mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'Classical' and 'new' diabetogens--comparison of their effects on isolated rat pancreatic islets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of trace metals on alloxan cytotoxicity in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan Uptake by Isolated Rat Islets of Langerhans*

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus in rabbits injected with dialuric acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione-mediated redox cycling of alloxan. Mechanisms of superoxide dismutase inhibition and of metal-catalyzed OH. formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alloxan in rabbits with temporary occlusion of the arteries to the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinsulin biosynthesis by pancreatic islets of the rat and the study of alloxan cytotoxicity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of free radicals by alloxan in the presence of bovine serum albumin: a role of protein sulfhydryl groups in alloxan cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of streptozotocin on a clonal isolate of rat insulinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan and dialuric acid; their stabilities and ultraviolet absorption spectra

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diabetogenic effect of alloxan after elimination of extra-pancreatic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of alloxan and anomers of D-glucose on glucose-induced insulin secretion and biosynthesis in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of labelled streptozotocin in mice: uptake and retention in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of Labeled Alloxan in Mouse Organs and Mitochondriain Vivoandin Vitro*

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term in vitro effects of streptozotocin, interleukin-1, and high glucose concentration on the activity of mitochondrial dehydrogenases and the secretion of insulin in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against alloxan-induced diabetes by various urea derivatives: relationship between protective effects and reactivity with the hydroxyl radical

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of nitrosourea-induced beta-cell damage. Alterations in DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of compound 305 requires the simultaneous generation of both alloxan and GSH radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoradiographic study of the distribution and cellular uptake of (14C)-streptozotocin in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of nitrosourea-induced beta-cell damage. Activation of poly (ADP-ribose) synthetase and cellular distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloxan diabetes: the sorcerer and his apprentice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal recognition by pancreatic B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of the diabetogenic action of alloxan by sulfhydryl compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18087688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-007-0886-7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

0 references

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