(Q34726862)

4 August 2017

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title

The mechanisms of alloxan- and streptozotocin-induced diabetes (English)

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4 August 2017

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ChEBI release 2020-05-28

Lenzen S

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4 August 2017

publication date

18 December 2007

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4 August 2017

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

216-226

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Selective uptake of alloxan by pancreatic B-cells

4 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose for protection against inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

Effects of alloxan on the islets of Langerhans: inhibition of leucine metabolism and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0886-7

Inhibition of rat liver glucokinase by alloxan and ninhydrin

21 January 2018

1 reference

12 December 2020

Alloxan Stimulation and Inhibition of Insulin Release from Isolated Rat Islets of Langerhans

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12 December 2020

Acute effects of alloxan on the metabolism and insulin secretion of the pancreatic B-cell

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12 December 2020

Allopurinol protects pancreatic beta cells from the cytotoxic effect of streptozotocin: in vitro study

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12 December 2020

Streptozotocin: depression of mouse liver pyridine nucleotides

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12 December 2020

Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan

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12 December 2020

Glucokinase in pancreatic B-cells and its inhibition by alloxan

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12 December 2020

Pancreatic uptake of [2-(14)C]alloxan

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12 December 2020

Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan

1 reference

12 December 2020

The Mechanism of Cysteine and Glutathione Protection Against Alloxan Diabetes

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12 December 2020

GLUT2 in Pancreatic Islets: Crucial Target Molecule in Diabetes Induced With Multiple Low Doses of Streptozotocin in Mice

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12 December 2020

The prevention of alloxan-induced diabetes in mice by the iron-chelator detapac: suggestion of a role for iron in the cytotoxic process

1 reference

12 December 2020

Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species

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12 December 2020

Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells

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12 December 2020

Alloxan studies; the action of alloxan homologues and related compounds

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12 December 2020

Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells

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12 December 2020

Studies on the mechanism of alloxan inhibition of glucose-induced insulin release

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12 December 2020

Drugs producing diabetes through damage of the insulin secreting cells

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12 December 2020

Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets

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12 December 2020

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

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12 December 2020

Alkylation of DNA in rat tissues following administration of streptozotocin

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12 December 2020

Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms

1 reference

12 December 2020

The role of O-linked protein glycosylation in beta-cell dysfunction

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12 December 2020

Molecular requirements for recognition at glucoreceptor for insulin release

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12 December 2020

Clinical antitumor activity and toxicity of streptozotocin (NSC-85998)

1 reference

12 December 2020

Free radicals and diabetes

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12 December 2020

On the accumulation of alloxan in the pancreatic beta-cells.

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12 December 2020

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

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12 December 2020

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

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12 December 2020

Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

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12 December 2020

Scavenging effect of melatonin on hydroxyl radicals generated by alloxan

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12 December 2020

Studies on the diabetogenic action of streptozotocin (NSC-37917)

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12 December 2020

Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide

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12 December 2020

The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives

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12 December 2020

Streptozocin: a review of its pharmacology, efficacy, and toxicity

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12 December 2020

Alloxan: history and mechanism of action

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12 December 2020

'Classical' and 'new' diabetogens--comparison of their effects on isolated rat pancreatic islets in vitro

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12 December 2020

Influence of trace metals on alloxan cytotoxicity in pancreatic islets

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12 December 2020

Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate

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12 December 2020

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

1 reference

12 December 2020

Alloxan Uptake by Isolated Rat Islets of Langerhans*

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12 December 2020

Diabetes mellitus in rabbits injected with dialuric acid

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12 December 2020

Glutathione-mediated redox cycling of alloxan. Mechanisms of superoxide dismutase inhibition and of metal-catalyzed OH. formation

1 reference

12 December 2020

Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase

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12 December 2020

Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin

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12 December 2020

Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose

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12 December 2020

Effect of alloxan in rabbits with temporary occlusion of the arteries to the pancreas

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12 December 2020

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis

1 reference

12 December 2020

Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro

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12 December 2020

Proinsulin biosynthesis by pancreatic islets of the rat and the study of alloxan cytotoxicity in vitro

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12 December 2020

Generation of free radicals by alloxan in the presence of bovine serum albumin: a role of protein sulfhydryl groups in alloxan cytotoxicity

1 reference

12 December 2020

Effects of streptozotocin on a clonal isolate of rat insulinoma cells

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12 December 2020

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

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12 December 2020

N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets

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12 December 2020

Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell

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12 December 2020

Alloxan and dialuric acid; their stabilities and ultraviolet absorption spectra

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12 December 2020

The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.

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12 December 2020

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin

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12 December 2020

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

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12 December 2020

The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.

1 reference

12 December 2020

Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure

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12 December 2020

The diabetogenic effect of alloxan after elimination of extra-pancreatic factors

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12 December 2020

Interaction of alloxan and anomers of D-glucose on glucose-induced insulin secretion and biosynthesis in vitro

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12 December 2020

Distribution of labelled streptozotocin in mice: uptake and retention in pancreatic islets

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12 December 2020

Uptake of Labeled Alloxan in Mouse Organs and Mitochondriain Vivoandin Vitro*

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12 December 2020

Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro

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12 December 2020

Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin

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12 December 2020

STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

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12 December 2020

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12 December 2020

Poly (ADP-ribose) polymerase, nitric oxide and cell death

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12 December 2020

Long term in vitro effects of streptozotocin, interleukin-1, and high glucose concentration on the activity of mitochondrial dehydrogenases and the secretion of insulin in pancreatic islets

1 reference

12 December 2020

Protection against alloxan-induced diabetes by various urea derivatives: relationship between protective effects and reactivity with the hydroxyl radical

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12 December 2020

Mechanisms of nitrosourea-induced beta-cell damage. Alterations in DNA.

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12 December 2020

Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme

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12 December 2020

Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations

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12 December 2020

Formation of compound 305 requires the simultaneous generation of both alloxan and GSH radicals

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12 December 2020

Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan

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12 December 2020

Autoradiographic study of the distribution and cellular uptake of (14C)-streptozotocin in the rat

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12 December 2020

Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin

1 reference

12 December 2020

Mechanisms of nitrosourea-induced beta-cell damage. Activation of poly (ADP-ribose) synthetase and cellular distribution

1 reference

12 December 2020

Alloxan diabetes: the sorcerer and his apprentice

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12 December 2020

Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells

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12 December 2020

Signal recognition by pancreatic B-cells

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12 December 2020

Reversal of the diabetogenic action of alloxan by sulfhydryl compounds

1 reference

12 December 2020

Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability

1 reference

12 December 2020

10.1007/S00125-007-0886-7

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1028191032

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