Content
April 2022, Volume 18, Issue 4
- 1-13 Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index
by Allan Gurtan & John Dominy & Shareef Khalid & Linh Vong & Shari Caplan & Treeve Currie & Sean Richards & Lindsey Lamarche & Daniel Denning & Diana Shpektor & Anastasia Gurinovich & Asif Rasheed & Shahid Hameed & Subhan Saeed & Imran Saleem & Anjum Jalal & Shahid Abbas & Raffat Sultana & Syed Zahed Rasheed & Fazal-ur-Rehman Memon & Nabi Shah & Mohammad Ishaq & Amit V Khera & John Danesh & Philippe Frossard & Danish Saleheen - 1-37 A spatially aware likelihood test to detect sweeps from haplotype distributions
by Michael DeGiorgio & Zachary A Szpiech
March 2022, Volume 18, Issue 3
- 1-18 THUNDER: A reference-free deconvolution method to infer cell type proportions from bulk Hi-C data
by Bryce Rowland & Ruth Huh & Zoey Hou & Cheynna Crowley & Jia Wen & Yin Shen & Ming Hu & Paola Giusti-Rodríguez & Patrick F Sullivan & Yun Li - 1-20 BmPMFBP1 regulates the development of eupyrene sperm in the silkworm, Bombyx mori
by Dehong Yang & Jun Xu & Kai Chen & Yujia Liu & Xu Yang & Linmeng Tang & Xingyu Luo & Zulian Liu & Muwang Li & James R Walters & Yongping Huang - 1-21 Significant sparse polygenic risk scores across 813 traits in UK Biobank
by Yosuke Tanigawa & Junyang Qian & Guhan Venkataraman & Johanne Marie Justesen & Ruilin Li & Robert Tibshirani & Trevor Hastie & Manuel A Rivas - 1-21 Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods
by Yuanyuan Yu & Lei Hou & Xu Shi & Xiaoru Sun & Xinhui Liu & Yifan Yu & Zhongshang Yuan & Hongkai Li & Fuzhong Xue
February 2022, Volume 18, Issue 2
- 1-12 Soft selective sweeps: Addressing new definitions, evaluating competing models, and interpreting empirical outliers
by Parul Johri & Wolfgang Stephan & Jeffrey D Jensen - 1-25 Genomic legacy of migration in endangered caribou
by Maria Cavedon & Bridgett vonHoldt & Mark Hebblewhite & Troy Hegel & Elizabeth Heppenheimer & Dave Hervieux & Stefano Mariani & Helen Schwantje & Robin Steenweg & Jessica Theoret & Megan Watters & Marco Musiani - 1-27 From musk to body odor: Decoding olfaction through genetic variation
by Bingjie Li & Marissa L Kamarck & Qianqian Peng & Fei-Ling Lim & Andreas Keller & Monique A M Smeets & Joel D Mainland & Sijia Wang
January 2022, Volume 18, Issue 1
- 1-23 Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts
by Alexey D Vyatkin & Danila V Otnyukov & Sergey V Leonov & Aleksey V Belikov - 1-24 Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity
by Andrew J Grant & Dipender Gill & Paul D W Kirk & Stephen Burgess - 1-26 Redundant neural circuits regulate olfactory integration
by Wenxing Yang & Taihong Wu & Shasha Tu & Yuang Qin & Chengchen Shen & Jiangyun Li & Myung-Kyu Choi & Fengyun Duan & Yun Zhang - 1-27 Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila
by Shivohum Bahuguna & Magda Atilano & Marcus Glittenberg & Dohun Lee & Srishti Arora & Lihui Wang & Jun Zhou & Siamak Redhai & Michael Boutros & Petros Ligoxygakis
November 2021, Volume 17, Issue 11
- 1-19 Network-based protein-protein interaction prediction method maps perturbations of cancer interactome
by Jiajun Qiu & Kui Chen & Chunlong Zhong & Sihao Zhu & Xiao Ma - 1-20 The effects of introgression across thousands of quantitative traits revealed by gene expression in wild tomatoes
by Mark S Hibbins & Matthew W Hahn - 1-22 Prediction of heterosis in the recent rapeseed (Brassica napus) polyploid by pairing parental nucleotide sequences
by Qian Wang & Tao Yan & Zhengbiao Long & Luna Yue Huang & Yang Zhu & Ying Xu & Xiaoyang Chen & Haksong Pak & Jiqiang Li & Dezhi Wu & Yang Xu & Shuijin Hua & Lixi Jiang - 1-24 Evolution of ColE1-like plasmids across γ-Proteobacteria: From bacteriocin production to antimicrobial resistance
by Manuel Ares-Arroyo & Eduardo P C Rocha & Bruno Gonzalez-Zorn - 1-25 Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model
by Zhaotong Lin & Yangqing Deng & Wei Pan
October 2021, Volume 17, Issue 10
- 1-17 Machine learning to predict the source of campylobacteriosis using whole genome data
by Nicolas Arning & Samuel K Sheppard & Sion Bayliss & David A Clifton & Daniel J Wilson - 1-24 Haplotype associated RNA expression (HARE) improves prediction of complex traits in maize
by Anju Giri & Merritt Khaipho-Burch & Edward S Buckler & Guillaume P Ramstein - 1-27 Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
by Jiwon Jeong & Jongbin Lee & Ji-hyung Kim & Chunghun Lim - 1-37 Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR
by Anna Hutchinson & Guillermo Reales & Thomas Willis & Chris Wallace
September 2021, Volume 17, Issue 9
- 1-11 A more accurate method for colocalisation analysis allowing for multiple causal variants
by Chris Wallace - 1-19 Identifying causal variants by fine mapping across multiple studies
by Nathan LaPierre & Kodi Taraszka & Helen Huang & Rosemary He & Farhad Hormozdiari & Eleazar Eskin - 1-19 Genome-wide methylation data improves dissection of the effect of smoking on body mass index
by Carmen Amador & Yanni Zeng & Michael Barber & Rosie M Walker & Archie Campbell & Andrew M McIntosh & Kathryn L Evans & David J Porteous & Caroline Hayward & James F Wilson & Pau Navarro & Chris S Haley - 1-25 Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps
by Floria M K Uy & Christopher M Jernigan & Natalie C Zaba & Eshan Mehrotra & Sara E Miller & Michael J Sheehan - 1-28 A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation
by Payel Ganguly & Landiso Madonsela & Jesse T Chao & Christopher J R Loewen & Timothy P O’Connor & Esther M Verheyen & Douglas W Allan - 1-28 A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships
by Richard Howey & Alexander D Clark & Najib Naamane & Louise N Reynard & Arthur G Pratt & Heather J Cordell - 1-38 Rare variants in the endocytic pathway are associated with Alzheimer’s disease, its related phenotypes, and functional consequences
by Lingyu Zhan & Jiajin Li & Brandon Jew & Jae Hoon Sul
August 2021, Volume 17, Issue 8
- 1-24 Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens
by Jennifer T Pentz & Peter A Lind - 1-26 Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data
by Ciarrah Barry & Junxi Liu & Rebecca Richmond & Martin K Rutter & Deborah A Lawlor & Frank Dudbridge & Jack Bowden - 1-27 Average semivariance yields accurate estimates of the fraction of marker-associated genetic variance and heritability in complex trait analyses
by Mitchell J Feldmann & Hans-Peter Piepho & William C Bridges & Steven J Knapp - 1-36 Multitrait GWAS to connect disease variants and biological mechanisms
by Hanna Julienne & Vincent Laville & Zachary R McCaw & Zihuai He & Vincent Guillemot & Carla Lasry & Andrey Ziyatdinov & Cyril Nerin & Amaury Vaysse & Pierre Lechat & Hervé Ménager & Wilfried Le Goff & Marie-Pierre Dube & Peter Kraft & Iuliana Ionita-Laza & Bjarni J Vilhjálmsson & Hugues Aschard
July 2021, Volume 17, Issue 7
- 1-11 Meiosis in Quarantine discussions lead to an action plan to increase diversity and inclusion within the genetics community
by Katherine K Billmyre & María Angélica Bravo Núñez & Douglas K Bishop & Francesca Cole - 1-17 A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics
by Geyu Zhou & Hongyu Zhao - 1-24 A spectral theory for Wright’s inbreeding coefficients and related quantities
by Olivier François & Clément Gain - 1-28 Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios
by Debashree Ray & Sowmya Venkataraghavan & Wanying Zhang & Elizabeth J Leslie & Jacqueline B Hetmanski & Seth M Weinberg & Jeffrey C Murray & Mary L Marazita & Ingo Ruczinski & Margaret A Taub & Terri H Beaty
June 2021, Volume 17, Issue 6
- 1-13 A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
by Harry D Green & Alistair Jones & Jonathan P Evans & Andrew R Wood & Robin N Beaumont & Jessica Tyrrell & Timothy M Frayling & Christopher Smith & Michael N Weedon - 1-21 An autoregulatory negative feedback loop controls thermomorphogenesis in Arabidopsis
by Sanghwa Lee & Ling Zhu & Enamul Huq - 1-23 Predicting population genetic change in an autocorrelated random environment: Insights from a large automated experiment
by Marie Rescan & Daphné Grulois & Enrique Ortega Aboud & Pierre de Villemereuil & Luis-Miguel Chevin
May 2021, Volume 17, Issue 5
- 1-9 Gene action, genetic variation, and GWAS: A user-friendly web tool
by Valentin Hivert & Naomi R Wray & Peter M Visscher - 1-22 Evaluation of polygenic prediction methodology within a reference-standardized framework
by Oliver Pain & Kylie P Glanville & Saskia P Hagenaars & Saskia Selzam & Anna E Fürtjes & Héléna A Gaspar & Jonathan R I Coleman & Kaili Rimfeld & Gerome Breen & Robert Plomin & Lasse Folkersen & Cathryn M Lewis - 1-25 Evolution of plasticity in production and transgenerational inheritance of small RNAs under dynamic environmental conditions
by Willian T A F Silva & Sarah P Otto & Simone Immler - 1-27 Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images
by Hannah Currant & Pirro Hysi & Tomas W Fitzgerald & Puya Gharahkhani & Pieter W M Bonnemaijer & Anne Senabouth & Alex W Hewitt & UK Biobank Eye and Vision Consortium & International Glaucoma Genetics Consortium & Denize Atan & Tin Aung & Jason Charng & Hélène Choquet & Jamie Craig & Peng T Khaw & Caroline C W Klaver & Michiaki Kubo & Jue-Sheng Ong & Louis R Pasquale & Charles A Reisman & Maciej Daniszewski & Joseph E Powell & Alice Pébay & Mark J Simcoe & Alberta A H J Thiadens & Cornelia M van Duijn & Seyhan Yazar & Eric Jorgenson & Stuart MacGregor & Chris J Hammond & David A Mackey & Janey L Wiggs & Paul J Foster & Praveen J Patel & Ewan Birney & Anthony P Khawaja
April 2021, Volume 17, Issue 4
- 1-21 Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies
by Helian Feng & Nicholas Mancuso & Alexander Gusev & Arunabha Majumdar & Megan Major & Bogdan Pasaniuc & Peter Kraft - 1-24 MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity
by Anqi Zhu & Nana Matoba & Emma P Wilson & Amanda L Tapia & Yun Li & Joseph G Ibrahim & Jason L Stein & Michael I Love - 1-27 Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank
by Keira J A Johnston & Joey Ward & Pradipta R Ray & Mark J Adams & Andrew M McIntosh & Blair H Smith & Rona J Strawbridge & Theodore J Price & Daniel J Smith & Barbara I Nicholl & Mark E S Bailey
March 2021, Volume 17, Issue 3
- 1-19 Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
by Corina Lesseur & Aida Ferreiro-Iglesias & James D McKay & Yohan Bossé & Mattias Johansson & Valerie Gaborieau & Maria Teresa Landi & David C Christiani & Neil C Caporaso & Stig E Bojesen & Christopher I Amos & Sanjay Shete & Geoffrey Liu & Gadi Rennert & Demetrios Albanes & Melinda C Aldrich & Adonina Tardon & Chu Chen & Liloglou Triantafillos & John K Field & Marion Dawn Teare & Lambertus A Kiemeney & Brenda Diergaarde & Robert L Ferris & Shanbeh Zienolddiny & Stephen Lam & Andrew F Olshan & Mark C Weissler & Martin Lacko & Angela Risch & Heike Bickeböller & Andy R Ness & Steve Thomas & Loic Le Marchand & Matthew B Schabath & Victor Wünsch-Filho & Eloiza H Tajara & Angeline S Andrew & Gary M Clifford & Philip Lazarus & Kjell Grankvist & Mikael Johansson & Susanne Arnold & Olle Melander & Hans Brunnström & Stefania Boccia & Gabriella Cadoni & Wim Timens & Ma’en Obeidat & Xiangjun Xiao & Richard S Houlston & Rayjean J Hung & Paul Brennan - 1-20 Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci
by Michael Francis & Changwei Li & Yitang Sun & Jingqi Zhou & Xiang Li & J Thomas Brenna & Kaixiong Ye - 1-26 Changes in the fine-scale genetic structure of Finland through the 20th century
by Sini Kerminen & Nicola Cerioli & Darius Pacauskas & Aki S Havulinna & Markus Perola & Pekka Jousilahti & Veikko Salomaa & Mark J Daly & Rupesh Vyas & Samuli Ripatti & Matti Pirinen - 1-30 MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies
by Arjun Bhattacharya & Yun Li & Michael I Love
February 2021, Volume 17, Issue 2
- 1-20 Power analysis of transcriptome-wide association study: Implications for practical protocol choice
by Chen Cao & Bowei Ding & Qing Li & Devin Kwok & Jingjing Wu & Quan Long - 1-22 Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease
by Nana Liu & Jiayuan Xu & Huaigui Liu & Shijie Zhang & Miaoxin Li & Yao Zhou & Wen Qin & Mulin Jun Li & Chunshui Yu & for the Alzheimer’s disease Neuroimaging Initiative - 1-25 Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder
by Kunling Huang & Yuchang Wu & Junha Shin & Ye Zheng & Alireza Fotuhi Siahpirani & Yupei Lin & Zheng Ni & Jiawen Chen & Jing You & Sunduz Keles & Daifeng Wang & Sushmita Roy & Qiongshi Lu - 1-28 Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles
by Kathryn A Jewett & Ruth E Thomas & Chi Q Phan & Bernice Lin & Gillian Milstein & Selina Yu & Lisa F Bettcher & Fausto Carnevale Neto & Danijel Djukovic & Daniel Raftery & Leo J Pallanck & Marie Y Davis
January 2021, Volume 17, Issue 1
- 1-18 Population structure of indigenous inhabitants of Arabia
by Katsuhiko Mineta & Kosuke Goto & Takashi Gojobori & Fowzan S Alkuraya - 1-19 RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID
by Ardalan Naseri & Junjie Shi & Xihong Lin & Shaojie Zhang & Degui Zhi - 1-23 Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships
by Matthew J Harder & Julie Hix & Wendy M Reeves & Michael T Veeman - 1-25 Accurate genetic and environmental covariance estimation with composite likelihood in genome-wide association studies
by Boran Gao & Can Yang & Jin Liu & Xiang Zhou - 1-26 Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome
by Denis A Baird & Jimmy Z Liu & Jie Zheng & Solveig K Sieberts & Thanneer Perumal & Benjamin Elsworth & Tom G Richardson & Chia-Yen Chen & Minerva M Carrasquillo & Mariet Allen & Joseph S Reddy & Philip L De Jager & Nilufer Ertekin-Taner & Lara M Mangravite & Ben Logsdon & Karol Estrada & Philip C Haycock & Gibran Hemani & Heiko Runz & George Davey Smith & Tom R Gaunt & AMP-AD eQTL working group - 1-27 Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment
by Sébastien Boyer & Lucas Hérissant & Gavin Sherlock - 1-36 Estimating FST and kinship for arbitrary population structures
by Alejandro Ochoa & John D Storey
December 2020, Volume 16, Issue 12
- 1-15 Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies
by Robin N Beaumont & Sarah J Kotecha & Andrew R Wood & Bridget A Knight & Sylvain Sebert & Mark I McCarthy & Andrew T Hattersley & Marjo-Riitta Järvelin & Nicholas J Timpson & Rachel M Freathy & Sailesh Kotecha - 1-23 Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis
by Corbin Quick & Xiaoquan Wen & Gonçalo Abecasis & Michael Boehnke & Hyun Min Kang - 1-25 A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
by Debashree Ray & Nilanjan Chatterjee - 1-28 Super-resolution visualization of distinct stalled and broken replication fork structures
by Donna R Whelan & Wei Ting C Lee & Frances Marks & Yu Tina Kong & Yandong Yin & Eli Rothenberg
November 2020, Volume 16, Issue 11
- 1-19 Genotype imputation using the Positional Burrows Wheeler Transform
by Simone Rubinacci & Olivier Delaneau & Jonathan Marchini - 1-20 Multivariable G-E interplay in the prediction of educational achievement
by Andrea G Allegrini & Ville Karhunen & Jonathan R I Coleman & Saskia Selzam & Kaili Rimfeld & Sophie von Stumm & Jean-Baptiste Pingault & Robert Plomin - 1-23 LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks
by Jeffery A Goldstein & Joshua S Weinstock & Lisa A Bastarache & Daniel B Larach & Lars G Fritsche & Ellen M Schmidt & Chad M Brummett & Sachin Kheterpal & Goncalo R Abecasis & Joshua C Denny & Matthew Zawistowski - 1-24 Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency
by Federica Diofano & Karolina Weinmann & Isabelle Schneider & Kevin D Thiessen & Wolfgang Rottbauer & Steffen Just - 1-30 Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data
by Haoran Xue & Wei Pan
October 2020, Volume 16, Issue 10
- 1-2 By what name shall I call thee?
by Gregory S Barsh & Gregory P Copenhaver - 1-20 Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes
by Koji Ishikawa & Akari Ishihara & Hisao Moriya - 1-21 AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections
by Qiankun He & Juan Du & Liya Wei & Zhangwu Zhao - 1-21 Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation
by Brendan Evano & Diljeet Gill & Irene Hernando-Herraez & Glenda Comai & Thomas M Stubbs & Pierre-Henri Commere & Wolf Reik & Shahragim Tajbakhsh - 1-22 Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms
by Xinyue Li & Hongyu Zhao - 1-23 A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices
by James A Watson & Aimee R Taylor & Elizabeth A Ashley & Arjen Dondorp & Caroline O Buckee & Nicholas J White & Chris C Holmes - 1-25 Selection for ancient periodic motifs that do not impart DNA bending
by Aletheia Atzinger & Jeffrey G Lawrence - 1-26 Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
by Suzanne Vogelezang & Jonathan P Bradfield & Tarunveer S Ahluwalia & John A Curtin & Timo A Lakka & Niels Grarup & Markus Scholz & Peter J van der Most & Claire Monnereau & Evie Stergiakouli & Anni Heiskala & Momoko Horikoshi & Iryna O Fedko & Natalia Vilor-Tejedor & Diana L Cousminer & Marie Standl & Carol A Wang & Jorma Viikari & Frank Geller & Carmen Íñiguez & Niina Pitkänen & Alessandra Chesi & Jonas Bacelis & Loic Yengo & Maties Torrent & Ioanna Ntalla & Øyvind Helgeland & Saskia Selzam & Judith M Vonk & Mohammed H Zafarmand & Barbara Heude & Ismaa Sadaf Farooqi & Akram Alyass & Robin N Beaumont & Christian T Have & Peter Rzehak & Jose Ramon Bilbao & Theresia M Schnurr & Inês Barroso & Klaus Bønnelykke & Lawrence J Beilin & Lisbeth Carstensen & Marie-Aline Charles & Bo Chawes & Karine Clément & Ricardo Closa-Monasterolo & Adnan Custovic & Johan G Eriksson & Joaquin Escribano & Maria Groen-Blokhuis & Veit Grote & Dariusz Gruszfeld & Hakon Hakonarson & Torben Hansen & Andrew T Hattersley & Mette Hollensted & Jouke-Jan Hottenga & Elina Hyppönen & Stefan Johansson & Raimo Joro & Mika Kähönen & Ville Karhunen & Wieland Kiess & Bridget A Knight & Berthold Koletzko & Andreas Kühnapfel & Kathrin Landgraf & Jean-Paul Langhendries & Terho Lehtimäki & Jaakko T Leinonen & Aihuali Li & Virpi Lindi & Estelle Lowry & Mariona Bustamante & Carolina Medina-Gomez & Mads Melbye & Kim F Michaelsen & Camilla S Morgen & Trevor A Mori & Tenna R H Nielsen & Harri Niinikoski & Albertine J Oldehinkel & Katja Pahkala & Kalliope Panoutsopoulou & Oluf Pedersen & Craig E Pennell & Christine Power & Sijmen A Reijneveld & Fernando Rivadeneira & Angela Simpson & Peter D Sly & Jakob Stokholm & Kook K Teo & Elisabeth Thiering & Nicholas J Timpson & André G Uitterlinden & Catharina E M van Beijsterveldt & Barbera D C van Schaik & Marc Vaudel & Elvira Verduci & Rebecca K Vinding & Mandy Vogel & Eleftheria Zeggini & Sylvain Sebert & Mads V Lind & Christopher D Brown & Loreto Santa-Marina & Eva Reischl & Christine Frithioff-Bøjsøe & David Meyre & Eleanor Wheeler & Ken Ong & Ellen A Nohr & Tanja G M Vrijkotte & Gerard H Koppelman & Robert Plomin & Pål R Njølstad & George D Dedoussis & Philippe Froguel & Thorkild I A Sørensen & Bo Jacobsson & Rachel M Freathy & Babette S Zemel & Olli Raitakari & Martine Vrijheid & Bjarke Feenstra & Leo-Pekka Lyytikäinen & Harold Snieder & Holger Kirsten & Patrick G Holt & Joachim Heinrich & Elisabeth Widén & Jordi Sunyer & Dorret I Boomsma & Marjo-Riitta Järvelin & Antje Körner & George Davey Smith & Jens-Christian Holm & Mustafa Atalay & Clare Murray & Hans Bisgaard & Mark I McCarthy & Early Growth Genetics Consortium & Vincent W V Jaddoe & Struan F A Grant & Janine F Felix - 1-29 Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
by Liang-Dar Hwang & Justin D Tubbs & Justin Luong & Mischa Lundberg & Gunn-Helen Moen & Geng Wang & Nicole M Warrington & Pak C Sham & Gabriel Cuellar-Partida & David M Evans - 1-30 A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank
by Junyang Qian & Yosuke Tanigawa & Wenfei Du & Matthew Aguirre & Chris Chang & Robert Tibshirani & Manuel A Rivas & Trevor Hastie
September 2020, Volume 16, Issue 9
- 1-23 The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance
by Zong Miao & Marcus Alvarez & Arthur Ko & Yash Bhagat & Elior Rahmani & Brandon Jew & Sini Heinonen & Linda Liliana Muñoz-Hernandez & Miguel Herrera-Hernandez & Carlos Aguilar-Salinas & Teresa Tusie-Luna & Karen L Mohlke & Markku Laakso & Kirsi H Pietiläinen & Eran Halperin & Päivi Pajukanta - 1-27 Restriction on self-renewing asymmetric division is coupled to terminal asymmetric division in the Drosophila CNS
by Ivana Gaziova & Michael Gazi & Jordan Mar & Krishna Moorthi Bhat - 1-35 Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts
by Jie Yuan & Henry Xing & Alexandre Louis Lamy & The Schizophrenia Working Group of the Psychiatric Genomics Consortium & Todd Lencz & Itsik Pe’er
August 2020, Volume 16, Issue 8
- 1-19 Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction
by Zhengcao Li & Henner Simianer - 1-19 Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p
by Anthony V Furano & Charlie E Jones & Vipul Periwal & Kathryn E Callahan & Jean-Claude Walser & Pamela R Cook - 1-21 A general framework for functionally informed set-based analysis: Application to a large-scale colorectal cancer study
by Xinyuan Dong & Yu-Ru Su & Richard Barfield & Stephanie A Bien & Qianchuan He & Tabitha A Harrison & Jeroen R Huyghe & Temitope O Keku & Noralane M Lindor & Clemens Schafmayer & Andrew T Chan & Stephen B Gruber & Mark A Jenkins & Charles Kooperberg & Ulrike Peters & Li Hsu - 1-24 Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph
by Melissa J Hubisz & Amy L Williams & Adam Siepel - 1-28 On the cross-population generalizability of gene expression prediction models
by Kevin L Keys & Angel C Y Mak & Marquitta J White & Walter L Eckalbar & Andrew W Dahl & Joel Mefford & Anna V Mikhaylova & María G Contreras & Jennifer R Elhawary & Celeste Eng & Donglei Hu & Scott Huntsman & Sam S Oh & Sandra Salazar & Michael A Lenoir & Jimmie C Ye & Timothy A Thornton & Noah Zaitlen & Esteban G Burchard & Christopher R Gignoux - 1-44 Learning the properties of adaptive regions with functional data analysis
by Mehreen R Mughal & Hillary Koch & Jinguo Huang & Francesca Chiaromonte & Michael DeGiorgio
July 2020, Volume 16, Issue 7
- 1-2 Mixed methods
by David J Balding & Gregory S Barsh & Gregory P Copenhaver & Chengqi Yi - 1-24 Unified inference of missense variant effects and gene constraints in the human genome
by Yi-Fei Huang - 1-24 Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
by Andrew D Bretherick & Oriol Canela-Xandri & Peter K Joshi & David W Clark & Konrad Rawlik & Thibaud S Boutin & Yanni Zeng & Carmen Amador & Pau Navarro & Igor Rudan & Alan F Wright & Harry Campbell & Veronique Vitart & Caroline Hayward & James F Wilson & Albert Tenesa & Chris P Ponting & J Kenneth Baillie & Chris Haley
June 2020, Volume 16, Issue 6
- 1-16 A Bayesian method to estimate variant-induced disease penetrance
by Brett M Kroncke & Derek K Smith & Yi Zuo & Andrew M Glazer & Dan M Roden & Jeffrey D Blume - 1-30 Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase
by Johan A Slotman & Maarten W Paul & Fabrizia Carofiglio & H Martijn de Gruiter & Tessa Vergroesen & Lieke Koornneef & Wiggert A van Cappellen & Adriaan B Houtsmuller & Willy M Baarends - 1-30 Protein-protein interaction network controlling establishment and maintenance of switchable cell polarity
by Luís António Menezes Carreira & Filipe Tostevin & Ulrich Gerland & Lotte Søgaard-Andersen - 1-48 Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits
by Wei Cheng & Sohini Ramachandran & Lorin Crawford
May 2020, Volume 16, Issue 5
- 1-12 Accounting for long-range correlations in genome-wide simulations of large cohorts
by Dominic Nelson & Jerome Kelleher & Aaron P Ragsdale & Claudia Moreau & Gil McVean & Simon Gravel - 1-19 Scalable probabilistic PCA for large-scale genetic variation data
by Aman Agrawal & Alec M Chiu & Minh Le & Eran Halperin & Sriram Sankararaman - 1-20 Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy
by Fasil Tekola-Ayele & Cuilin Zhang & Jing Wu & Katherine L Grantz & Mohammad L Rahman & Deepika Shrestha & Marion Ouidir & Tsegaselassie Workalemahu & Michael Y Tsai - 1-23 A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine
by Jakob von Frieling & Muhammed Naeem Faisal & Femke Sporn & Roxana Pfefferkorn & Stella Solveig Nolte & Felix Sommer & Philip Rosenstiel & Thomas Roeder - 1-23 ASEP: Gene-based detection of allele-specific expression cross individuals in a population by RNA sequencing
by Jiaxin Fan & Jian Hu & Chenyi Xue & Hanrui Zhang & Katalin Susztak & Muredach P Reilly & Rui Xiao & Mingyao Li - 1-25 Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models
by Sahir R Bhatnagar & Yi Yang & Tianyuan Lu & Erwin Schurr & JC Loredo-Osti & Marie Forest & Karim Oualkacha & Celia M T Greenwood - 1-26 Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution
by Christian D Huber & Bernard Y Kim & Kirk E Lohmueller - 1-28 Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae
by Davide Marchi & Kirankumar Santhakumar & Eleanor Markham & Nan Li & Karl-Heinz Storbeck & Nils Krone & Vincent T Cunliffe & Fredericus J M van Eeden - 1-30 Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
by Dominic Holland & Oleksandr Frei & Rahul Desikan & Chun-Chieh Fan & Alexey A Shadrin & Olav B Smeland & V S Sundar & Paul Thompson & Ole A Andreassen & Anders M Dale
April 2020, Volume 16, Issue 4
- 1-16 Technical and social issues influencing the adoption of preprints in the life sciences
by Naomi C Penfold & Jessica K Polka - 1-20 Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses
by Chris Wallace - 1-30 Leveraging gene co-expression patterns to infer trait-relevant tissues in genome-wide association studies
by Lulu Shang & Jennifer A Smith & Xiang Zhou
March 2020, Volume 16, Issue 3
- 1-6 What is ancestry?
by Iain Mathieson & Aylwyn Scally - 1-19 The influence of rare variants in circulating metabolic biomarkers
by Fernando Riveros-Mckay & Clare Oliver-Williams & Savita Karthikeyan & Klaudia Walter & Kousik Kundu & Willem H Ouwehand & David Roberts & Emanuele Di Angelantonio & Nicole Soranzo & John Danesh & INTERVAL Study & Eleanor Wheeler & Eleftheria Zeggini & Adam S Butterworth & Inês Barroso - 1-19 Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study
by Yao Hu & Mariaelisa Graff & Jeffrey Haessler & Steven Buyske & Stephanie A Bien & Ran Tao & Heather M Highland & Katherine K Nishimura & Niha Zubair & Yingchang Lu & Marie Verbanck & Austin T Hilliard & Derek Klarin & Scott M Damrauer & Yuk-Lam Ho & the VA Million Veteran Program & Peter W F Wilson & Kyong-Mi Chang & Philip S Tsao & Kelly Cho & Christopher J O’Donnell & Themistocles L Assimes & Lauren E Petty & Jennifer E Below & Ozan Dikilitas & Daniel J Schaid & Matthew L Kosel & Iftikhar J Kullo & Laura J Rasmussen-Torvik & Gail P Jarvik & Qiping Feng & Wei-Qi Wei & Eric B Larson & Frank D Mentch & Berta Almoguera & Patrick M Sleiman & Laura M Raffield & Adolfo Correa & Lisa W Martin & Martha Daviglus & Tara C Matise & Jose Luis Ambite & Christopher S Carlson & Ron Do & Ruth J F Loos & Lynne R Wilkens & Loic Le Marchand & Chris Haiman & Daniel O Stram & Lucia A Hindorff & Kari E North & Charles Kooperberg & Iona Cheng & Ulrike Peters - 1-23 Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia)
by Tuomas Hämälä & Amanda J Gorton & David A Moeller & Peter Tiffin - 1-23 Tracking human population structure through time from whole genome sequences
by Ke Wang & Iain Mathieson & Jared O’Connell & Stephan Schiffels - 1-26 Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity
by Elizabeth B Brown & Kreesha D Shah & Richard Faville & Benjamin Kottler & Alex C Keene - 1-35 Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data
by Richard Howey & So-Youn Shin & Caroline Relton & George Davey Smith & Heather J Cordell - 1-40 A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast
by Jessica M Tumolo & Nathaniel L Hepowit & Samika S Joshi & Jason A MacGurn
February 2020, Volume 16, Issue 2
- 1-19 A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria
by Ernest Diez Benavente & Monica Campos & Jody Phelan & Debbie Nolder & Jamille G Dombrowski & Claudio R F Marinho & Kanlaya Sriprawat & Aimee R Taylor & James Watson & Cally Roper & Francois Nosten & Colin J Sutherland & Susana Campino & Taane G Clark
January 2020, Volume 16, Issue 1
- 1-17 The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders
by Mette K Andersen & Emil Jørsboe & Line Skotte & Kristian Hanghøj & Camilla H Sandholt & Ida Moltke & Niels Grarup & Timo Kern & Yuvaraj Mahendran & Bolette Søborg & Peter Bjerregaard & Christina V L Larsen & Inger K Dahl-Petersen & Hemant K Tiwari & Bjarke Feenstra & Anders Koch & Howard W Wiener & Scarlett E Hopkins & Oluf Pedersen & Mads Melbye & Bert B Boyer & Marit E Jørgensen & Anders Albrechtsen & Torben Hansen - 1-25 High-throughput discovery of genetic determinants of circadian misalignment
by Tao Zhang & Pancheng Xie & Yingying Dong & Zhiwei Liu & Fei Zhou & Dejing Pan & Zhengyun Huang & Qiaocheng Zhai & Yue Gu & Qingyu Wu & Nobuhiko Tanaka & Yuichi Obata & Allan Bradley & Christopher J Lelliott & Sanger Institute Mouse Genetics Project & Lauryl M J Nutter & Colin McKerlie & Ann M Flenniken & Marie-France Champy & Tania Sorg & Yann Herault & Martin Hrabe De Angelis & Valerie Gailus Durner & Ann-Marie Mallon & Steve D M Brown & Terry Meehan & Helen E Parkinson & Damian Smedley & K C Kent Lloyd & Jun Yan & Xiang Gao & Je Kyung Seong & Chi-Kuang Leo Wang & Radislav Sedlacek & Yi Liu & Jan Rozman & Ling Yang & Ying Xu
December 2019, Volume 15, Issue 12
- 1-2 Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
by Felix Day & Tugce Karaderi & Michelle R Jones & Cindy Meun & Chunyan He & Alex Drong & Peter Kraft & Nan Lin & Hongyan Huang & Linda Broer & Reedik Magi & Richa Saxena & Triin Laisk & Margrit Urbanek & M Geoffrey Hayes & Gudmar Thorleifsson & Juan Fernandez-Tajes & Anubha Mahajan & Benjamin H Mullin & Bronwyn G A Stuckey & Timothy D Spector & Scott G Wilson & Mark O Goodarzi & Lea Davis & Barbara Obermayer-Pietsch & André G Uitterlinden & Verneri Anttila & Benjamin M Neale & Marjo-Riitta Jarvelin & Bart Fauser & Irina Kowalska & Jenny A Visser & Marianne Andersen & Ken Ong & Elisabet Stener-Victorin & David Ehrmann & Richard S Legro & Andres Salumets & Mark I McCarthy & Laure Morin-Papunen & Unnur Thorsteinsdottir & Kari Stefansson & the 23andMe Research Team & Unnur Styrkarsdottir & John R B Perry & Andrea Dunaif & Joop Laven & Steve Franks & Cecilia M Lindgren & Corrine K Welt - 1-20 An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior
by Tyler Buddell & Vladislav Friedman & Cody J Drozd & Christopher C Quinn - 1-24 Leveraging allelic imbalance to refine fine-mapping for eQTL studies
by Jennifer Zou & Farhad Hormozdiari & Brandon Jew & Stephane E Castel & Tuuli Lappalainen & Jason Ernst & Jae Hoon Sul & Eleazar Eskin - 1-29 Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives
by Madison Caballero & Daniel N Seidman & Ying Qiao & Jens Sannerud & Thomas D Dyer & Donna M Lehman & Joanne E Curran & Ravindranath Duggirala & John Blangero & Shai Carmi & Amy L Williams - 1-34 Common gardens in teosintes reveal the establishment of a syndrome of adaptation to altitude
by Margaux-Alison Fustier & Natalia E Martínez-Ainsworth & Jonás A Aguirre-Liguori & Anthony Venon & Hélène Corti & Agnès Rousselet & Fabrice Dumas & Hannes Dittberner & María G Camarena & Daniel Grimanelli & Otso Ovaskainen & Matthieu Falque & Laurence Moreau & Juliette de Meaux & Salvador Montes-Hernández & Luis E Eguiarte & Yves Vigouroux & Domenica Manicacci & Maud I Tenaillon
November 2019, Volume 15, Issue 11
- 1-15 Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies
by Andrew Schlafly & Ruth M Pfeiffer & Eduardo Nagore & Susana Puig & Donato Calista & Paola Ghiorzo & Chiara Menin & Maria Concetta Fargnoli & Ketty Peris & Lei Song & Tongwu Zhang & Jianxin Shi & Maria Teresa Landi & Joshua Neil Sampson - 1-21 Inference of recombination maps from a single pair of genomes and its application to ancient samples
by Gustavo V. Barroso & Nataša Puzović & Julien Y Dutheil - 1-24 UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts
by Alex Diaz-Papkovich & Luke Anderson-Trocmé & Chief Ben-Eghan & Simon Gravel - 1-30 A meta-analysis of genome-wide association studies of epigenetic age acceleration
by Jude Gibson & Tom C Russ & Toni-Kim Clarke & David M Howard & Robert F Hillary & Kathryn L Evans & Rosie M Walker & Mairead L Bermingham & Stewart W Morris & Archie Campbell & Caroline Hayward & Alison D Murray & David J Porteous & Steve Horvath & Ake T Lu & Andrew M McIntosh & Heather C Whalley & Riccardo E Marioni - 1-38 Microbial phenotypic heterogeneity in response to a metabolic toxin: Continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations
by Jessica A Lee & Siavash Riazi & Shahla Nemati & Jannell V Bazurto & Andreas E Vasdekis & Benjamin J Ridenhour & Christopher H Remien & Christopher J Marx
October 2019, Volume 15, Issue 10
- 1-18 Bayesian multivariate reanalysis of large genetic studies identifies many new associations
by Michael C Turchin & Matthew Stephens - 1-29 Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells
by Edwige B Garcin & Stéphanie Gon & Meghan R Sullivan & Gregory J Brunette & Anne De Cian & Jean-Paul Concordet & Carine Giovannangeli & Wilhelm G Dirks & Sonja Eberth & Kara A Bernstein & Rohit Prakash & Maria Jasin & Mauro Modesti
September 2019, Volume 15, Issue 9
- 1-1 Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells
by Yongming Wang & Jichang Wang & Anatharam Devaraj & Manvendra Singh & Ana Jimenez Orgaz & Jia-Xuan Chen & Matthias Selbach & Zoltán Ivics & Zsuzsanna Izsvák - 1-20 Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development
by Jian Zhou & Ignacio E Schor & Victoria Yao & Chandra L Theesfeld & Raquel Marco-Ferreres & Alicja Tadych & Eileen E M Furlong & Olga G Troyanskaya - 1-23 Native American admixture recapitulates population-specific migration and settlement of the continental United States
by I King Jordan & Lavanya Rishishwar & Andrew B Conley - 1-25 The inference of sex-biased human demography from whole-genome data
by Shaila Musharoff & Suyash Shringarpure & Carlos D Bustamante & Sohini Ramachandran - 1-32 An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data
by Aaron J Stern & Peter R Wilton & Rasmus Nielsen
August 2019, Volume 15, Issue 8
- 1-20 A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene
by Cavin Wong & Fei Chen & Najmeh Alirezaie & Yifan Wang & Adeline Cuggia & Ayelet Borgida & Spring Holter & Tatiana Lenko & Celine Domecq & Alzheimer’s Disease Neuroimaging Initiative & Gloria M Petersen & Sapna Syngal & Randall Brand & Anil K Rustgi & Michele L Cote & Elena Stoffel & Sara H Olson & Nicholas J Roberts & Mohammad R Akbari & Jacek Majewski & Alison P Klein & Celia M T Greenwood & Steven Gallinger & George Zogopoulos - 1-25 An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations
by Alexander Platt & Alyssa Pivirotto & Jared Knoblauch & Jody Hey
July 2019, Volume 15, Issue 7
- 1-1 Correction: Quorum sensing and stress-activated MAPK signaling repress yeast to hypha transition in the fission yeast Schizosaccharomyces japonicus
by Elisa Gómez-Gil & Alejandro Franco & Marisa Madrid & Beatriz Vázquez-Marín & Mariano Gacto & Jesualdo Fernández-Breis & Jero Vicente-Soler & Teresa Soto & José Cansado - 1-30 Novel protective and risk loci in hip dysplasia in German Shepherds
by Lea I Mikkola & Saila Holopainen & Anu K Lappalainen & Tiina Pessa-Morikawa & Thomas J P Augustine & Meharji Arumilli & Marjo K Hytönen & Osmo Hakosalo & Hannes Lohi & Antti Iivanainen
June 2019, Volume 15, Issue 6
- 1-7 Solving the missing heritability problem
by Alexander I Young - 1-19 Host-dependent nitrogen recycling as a mechanism of symbiont control in Aiptasia
by Guoxin Cui & Yi Jin Liew & Yong Li & Najeh Kharbatia & Noura I Zahran & Abdul-Hamid Emwas & Victor M Eguiluz & Manuel Aranda
May 2019, Volume 15, Issue 5
- 1-18 A statistical model for reference-free inference of archaic local ancestry
by Arun Durvasula & Sriram Sankararaman - 1-18 An integrative association method for omics data based on a modified Fisher’s method with application to childhood asthma
by Qi Yan & Nianjun Liu & Erick Forno & Glorisa Canino & Juan C Celedón & Wei Chen - 1-21 The evolution of hybrid fitness during speciation
by Andrius J Dagilis & Mark Kirkpatrick & Daniel I Bolnick - 1-22 Estimating variance components in population scale family trees
by Tal Shor & Iris Kalka & Dan Geiger & Yaniv Erlich & Omer Weissbrod
April 2019, Volume 15, Issue 4
- 1-1 Correction: Genetic variants influence on the placenta regulatory landscape
by Fabien Delahaye & Catherine Do & Yu Kong & Remi Ashkar & Martha Salas & Ben Tycko & Ronald Wapner & Francine Hughes - 1-16 Discovery and characterization of variance QTLs in human induced pluripotent stem cells
by Abhishek K Sarkar & Po-Yuan Tung & John D Blischak & Jonathan E Burnett & Yang I Li & Matthew Stephens & Yoav Gilad - 1-18 Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness
by Bowen Hu & Ning Shen & James J Li & Hyunseung Kang & Jinkuk Hong & Jason Fletcher & Jan Greenberg & Marsha R Mailick & Qiongshi Lu - 1-18 Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis
by Zhixiu Li & Servet Akar & Handan Yarkan & Sau Kuen Lee & Pınar Çetin & Gerçek Can & Gökce Kenar & Fernur Çapa & Omer Nuri Pamuk & Yavuz Pehlivan & Katie Cremin & Erika De Guzman & Jessica Harris & Lawrie Wheeler & Ahmadreza Jamshidi & Mahdi Vojdanian & Elham Farhadi & Nooshin Ahmadzadeh & Zeynep Yüce & Ediz Dalkılıç & Dilek Solmaz & Berrin Akın & Salim Dönmez & İsmail Sarı & Paul J Leo & Tony J Kenna & Fatos Önen & Mahdi Mahmoudi & Matthew A Brown & Nurullah Akkoc - 1-21 FunSPU: A versatile and adaptive multiple functional annotation-based association test of whole-genome sequencing data
by Yiding Ma & Peng Wei - 1-22 Reverse GWAS: Using genetics to identify and model phenotypic subtypes
by Andy Dahl & Na Cai & Arthur Ko & Markku Laakso & Päivi Pajukanta & Jonathan Flint & Noah Zaitlen - 1-31 Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep
by Brian E Cade & Han Chen & Adrienne M Stilp & Tin Louie & Sonia Ancoli-Israel & Raanan Arens & Richard Barfield & Jennifer E Below & Jianwen Cai & Matthew P Conomos & Daniel S Evans & Alexis C Frazier-Wood & Sina A Gharib & Kevin J Gleason & Daniel J Gottlieb & David R Hillman & W Craig Johnson & David J Lederer & Jiwon Lee & Jose S Loredo & Hao Mei & Sutapa Mukherjee & Sanjay R Patel & Wendy S Post & Shaun M Purcell & Alberto R Ramos & Kathryn J Reid & Ken Rice & Neomi A Shah & Tamar Sofer & Kent D Taylor & Timothy A Thornton & Heming Wang & Kristine Yaffe & Phyllis C Zee & Craig L Hanis & Lyle J Palmer & Jerome I Rotter & Katie L Stone & Gregory J Tranah & James G Wilson & Shamil R Sunyaev & Cathy C Laurie & Xiaofeng Zhu & Richa Saxena & Xihong Lin & Susan Redline
March 2019, Volume 15, Issue 3
- 1-25 Genetic effects on the commensal microbiota in inflammatory bowel disease patients
by Hugues Aschard & Vincent Laville & Eric Tchetgen Tchetgen & Dan Knights & Floris Imhann & Philippe Seksik & Noah Zaitlen & Mark S Silverberg & Jacques Cosnes & Rinse K Weersma & Ramnik Xavier & Laurent Beaugerie & David Skurnik & Harry Sokol - 1-27 Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic
by Ryan Sun & Shirley Hui & Gary D Bader & Xihong Lin & Peter Kraft
February 2019, Volume 15, Issue 2
- 1-20 Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization
by Louise A C Millard & Neil M Davies & Kate Tilling & Tom R Gaunt & George Davey Smith - 1-24 Fast and flexible linear mixed models for genome-wide genetics
by Daniel E Runcie & Lorin Crawford - 1-29 Spatial soft sweeps: Patterns of adaptation in populations with long-range dispersal
by Jayson Paulose & Joachim Hermisson & Oskar Hallatschek - 1-31 Transcription-dependent spreading of the Dal80 yeast GATA factor across the body of highly expressed genes
by Aria Ronsmans & Maxime Wery & Ugo Szachnowski & Camille Gautier & Marc Descrimes & Evelyne Dubois & Antonin Morillon & Isabelle Georis - 1-33 Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila
by Gabriel E Rech & María Bogaerts-Márquez & Maite G Barrón & Miriam Merenciano & José Luis Villanueva-Cañas & Vivien Horváth & Anna-Sophie Fiston-Lavier & Isabelle Luyten & Sandeep Venkataram & Hadi Quesneville & Dmitri A Petrov & Josefa González - 1-36 Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci
by Jiafen Gong & Fan Wang & Bowei Xiao & Naim Panjwani & Fan Lin & Katherine Keenan & Julie Avolio & Mohsen Esmaeili & Lin Zhang & Gengming He & David Soave & Scott Mastromatteo & Zeynep Baskurt & Sangook Kim & Wanda K O’Neal & Deepika Polineni & Scott M Blackman & Harriet Corvol & Garry R Cutting & Mitchell Drumm & Michael R Knowles & Johanna M Rommens & Lei Sun & Lisa J Strug
January 2019, Volume 15, Issue 1
- 1-1 Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish
by Anna M Sokol & Barbara Uszczynska-Ratajczak & Michelle M Collins & Michal Bazala & Ulrike Topf & Pia R Lundegaard & Sreedevi Sugunan & Stefan Guenther & Carsten Kuenne & Johannes Graumann & Sherine S L Chan & Didier Y R Stainier & Agnieszka Chacinska - 1-1 Correction: Human demographic history has amplified the effects of background selection across the genome
by Raul Torres & Zachary A Szpiech & Ryan D Hernandez - 1-20 Integrating predicted transcriptome from multiple tissues improves association detection
by Alvaro N Barbeira & Milton Pividori & Jiamao Zheng & Heather E Wheeler & Dan L Nicolae & Hae Kyung Im - 1-21 Estimating recent migration and population-size surfaces
by Hussein Al-Asadi & Desislava Petkova & Matthew Stephens & John Novembre - 1-25 Genetic architecture of human thinness compared to severe obesity
by Fernando Riveros-McKay & Vanisha Mistry & Rebecca Bounds & Audrey Hendricks & Julia M Keogh & Hannah Thomas & Elana Henning & Laura J Corbin & Understanding Society Scientific Group & Stephen O’Rahilly & Eleftheria Zeggini & Eleanor Wheeler & Inês Barroso & I Sadaf Farooqi - 1-27 Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry
by Calvin Chi & Xiaorong Shao & Brooke Rhead & Edlin Gonzales & Jessica B Smith & Anny H Xiang & Jennifer Graves & Amy Waldman & Timothy Lotze & Teri Schreiner & Bianca Weinstock-Guttman & Gregory Aaen & Jan-Mendelt Tillema & Jayne Ness & Meghan Candee & Lauren Krupp & Mark Gorman & Leslie Benson & Tanuja Chitnis & Soe Mar & Anita Belman & Theron Charles Casper & John Rose & Manikum Moodley & Mary Rensel & Moses Rodriguez & Benjamin Greenberg & Llana Kahn & Jennifer Rubin & Catherine Schaefer & Emmanuelle Waubant & Annette Langer-Gould & Lisa F Barcellos - 1-29 Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting
by Orsolya Symmons & Marcello Chang & Ian A Mellis & Jennifer M Kalish & Jihwan Park & Katalin Suszták & Marisa S Bartolomei & Arjun Raj - 1-32 Diapause induces functional axonal regeneration after necrotic insult in C. elegans
by Mauricio Caneo & Victoria Julian & Alexandra B Byrne & Mark J Alkema & Andrea Calixto
December 2018, Volume 14, Issue 12
- 1-1 Correction: Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV
by Kristof Theys & Alison F Feder & Maoz Gelbart & Marion Hartl & Adi Stern & Pleuni S Pennings - 1-2 Doubling down on forensic twin studies
by Gregory P Copenhaver & Bruce Weir & Mark Rothstein & Hua Tang & Scott M Williams & Gregory S Barsh - 1-15 Expression reflects population structure
by Brielin C Brown & Nicolas L Bray & Lior Pachter - 1-15 Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity
by Shouneng Peng & Maya A Deyssenroth & Antonio F Di Narzo & Haoxiang Cheng & Zhongyang Zhang & Luca Lambertini & Arno Ruusalepp & Jason C Kovacic & Johan L M Bjorkegren & Carmen J Marsit & Jia Chen & Ke Hao - 1-20 Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
by Felix Day & Tugce Karaderi & Michelle R Jones & Cindy Meun & Chunyan He & Alex Drong & Peter Kraft & Nan Lin & Hongyan Huang & Linda Broer & Reedik Magi & Richa Saxena & Triin Laisk & Margrit Urbanek & M Geoffrey Hayes & Gudmar Thorleifsson & Juan Fernandez-Tajes & Anubha Mahajan & Benjamin H Mullin & Bronwyn G A Stuckey & Timothy D Spector & Scott G Wilson & Mark O Goodarzi & Lea Davis & Barbara Obermayer-Pietsch & André G Uitterlinden & Verneri Anttila & Benjamin M Neale & Marjo-Riitta Jarvelin & Bart Fauser & Irina Kowalska & Jenny A Visser & Marianne Andersen & Ken Ong & Elisabet Stener-Victorin & David Ehrmann & Richard S Legro & Andres Salumets & Mark I McCarthy & Laure Morin-Papunen & Unnur Thorsteinsdottir & Kari Stefansson & the 23andMe Research Team & Unnur Styrkarsdottir & John R B Perry & Andrea Dunaif & Joop Laven & Steve Franks & Cecilia M Lindgren & Corrine K Welt - 1-21 On the unfounded enthusiasm for soft selective sweeps II: Examining recent evidence from humans, flies, and viruses
by Rebecca B Harris & Andrew Sackman & Jeffrey D Jensen - 1-27 Bayesian multiple logistic regression for case-control GWAS
by Saikat Banerjee & Lingyao Zeng & Heribert Schunkert & Johannes Söding - 1-42 Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo
by Quira Zeidan & Feng He & Fan Zhang & Hongen Zhang & Allan Jacobson & Alan G Hinnebusch
November 2018, Volume 14, Issue 11
- 1-11 How many individuals share a mitochondrial genome?
by Mikkel M Andersen & David J Balding - 1-18 Association analysis using somatic mutations
by Yang Liu & Qianchan He & Wei Sun - 1-22 Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium
by Nhung H Vuong & David P Cook & Laura A Forrest & Lauren E Carter & Pascale Robineau-Charette & Joshua M Kofsky & Kendra M Hodgkinson & Barbara C Vanderhyden
October 2018, Volume 14, Issue 10
- 1-14 ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls
by Audrey E Hendricks & Stephen C Billups & Hamish N C Pike & I Sadaf Farooqi & Eleftheria Zeggini & Stephanie A Santorico & Inês Barroso & Josée Dupuis - 1-15 Metabolic adaptations underlying genome flexibility in prokaryotes
by Akshit Goyal - 1-21 Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits
by Guanghao Qi & Nilanjan Chatterjee - 1-22 Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia
by William K Scott & Felix Mba Medie & Felicia Ruffin & Batu K Sharma-Kuinkel & Derek D Cyr & Shengru Guo & Derek M Dykxhoorn & Robert L Skov & Niels E Bruun & Anders Dahl & Christian J Lerche & Andreas Petersen & Anders Rhod Larsen & Trine Kiilerich Lauridsen & Helle Krogh Johansen & Henrik Ullum & Erik Sørensen & Christian Hassager & Henning Bundgaard & Henrik C Schønheyder & Christian Torp-Pedersen & Louise Bruun Østergaard & Magnus Arpi & Flemming Rosenvinge & Lise T Erikstrup & Mahtab Chehri & Peter Søgaard & Paal S Andersen & Vance G Fowler Jr. - 1-25 A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery
by Patricia D A Rohs & Jackson Buss & Sue I Sim & Georgia R Squyres & Veerasak Srisuknimit & Mandy Smith & Hongbaek Cho & Megan Sjodt & Andrew C Kruse & Ethan C Garner & Suzanne Walker & Daniel E Kahne & Thomas G Bernhardt - 1-30 Deleterious variation shapes the genomic landscape of introgression
by Bernard Y Kim & Christian D Huber & Kirk E Lohmueller - 1-32 A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest
by Kleio Petratou & Tatiana Subkhankulova & James A Lister & Andrea Rocco & Hartmut Schwetlick & Robert N Kelsh - 1-37 A novel framework for inferring parameters of transmission from viral sequence data
by Casper K Lumby & Nuno R Nene & Christopher J R Illingworth
September 2018, Volume 14, Issue 9
- 1-1 Correction: Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth
by Johanna M Huusko & Minna K Karjalainen & Britney E Graham & Ge Zhang & Emily G Farrow & Neil A Miller & Bo Jacobsson & Haley R Eidem & Jeffrey C Murray & Bruce Bedell & Patrick Breheny & Noah W Brown & Frans L Bødker & Nadia K Litterman & Pan-Pan Jiang & Laura Russell & David A Hinds & Youna Hu & the 23andMe Research Team & Antonis Rokas & Kari Teramo & Kaare Christensen & Scott M Williams & Mika Rämet & Stephen F Kingsmore & Kelli K Ryckman & Mikko Hallman & Louis J Muglia - 1-15 Detecting archaic introgression using an unadmixed outgroup
by Laurits Skov & Ruoyun Hui & Vladimir Shchur & Asger Hobolth & Aylwyn Scally & Mikkel Heide Schierup & Richard Durbin - 1-18 Mutation load dynamics during environmentally-driven range shifts
by Kimberly J Gilbert & Stephan Peischl & Laurent Excoffier - 1-22 Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans
by Sijie Wu & Manfei Zhang & Xinzhou Yang & Fuduan Peng & Juan Zhang & Jingze Tan & Yajun Yang & Lina Wang & Yanan Hu & Qianqian Peng & Jinxi Li & Yu Liu & Yaqun Guan & Chen Chen & Merel A Hamer & Tamar Nijsten & Changqing Zeng & Kaustubh Adhikari & Carla Gallo & Giovanni Poletti & Lavinia Schuler-Faccini & Maria-Cátira Bortolini & Samuel Canizales-Quinteros & Francisco Rothhammer & Gabriel Bedoya & Rolando González-José & Hui Li & Jean Krutmann & Fan Liu & Manfred Kayser & Andres Ruiz-Linares & Kun Tang & Shuhua Xu & Liang Zhang & Li Jin & Sijia Wang - 1-23 Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
by Pradeep Suri & Melody R Palmer & Yakov A Tsepilov & Maxim B Freidin & Cindy G Boer & Michelle S Yau & Daniel S Evans & Andrea Gelemanovic & Traci M Bartz & Maria Nethander & Liubov Arbeeva & Lennart Karssen & Tuhina Neogi & Archie Campbell & Dan Mellstrom & Claes Ohlsson & Lynn M Marshall & Eric Orwoll & Andre Uitterlinden & Jerome I Rotter & Gordan Lauc & Bruce M Psaty & Magnus K Karlsson & Nancy E Lane & Gail P Jarvik & Ozren Polasek & Marc Hochberg & Joanne M Jordan & Joyce B J Van Meurs & Rebecca Jackson & Carrie M Nielson & Braxton D Mitchell & Blair H Smith & Caroline Hayward & Nicholas L Smith & Yurii S Aulchenko & Frances M K Williams - 1-24 Distinct CED-10/Rac1 domains confer context-specific functions in development
by Steffen Nørgaard & Shuer Deng & Wei Cao & Roger Pocock
August 2018, Volume 14, Issue 8
- 1-18 Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
by Laurence J Howe & Myoung Keun Lee & Gemma C Sharp & George Davey Smith & Beate St Pourcain & John R Shaffer & Kerstin U Ludwig & Elisabeth Mangold & Mary L Marazita & Eleanor Feingold & Alexei Zhurov & Evie Stergiakouli & Jonathan Sandy & Stephen Richmond & Seth M Weinberg & Gibran Hemani & Sarah J Lewis - 1-19 A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1
by Ying Chen & Melissa A Gilbert & Christopher M Grochowski & Deborah McEldrew & Jessica Llewellyn & Orith Waisbourd-Zinman & Hakon Hakonarson & Joan E Bailey-Wilson & Pierre Russo & Rebecca G Wells & Kathleen M Loomes & Nancy B Spinner & Marcella Devoto - 1-21 Genetic architecture of gene expression traits across diverse populations
by Lauren S Mogil & Angela Andaleon & Alexa Badalamenti & Scott P Dickinson & Xiuqing Guo & Jerome I Rotter & W Craig Johnson & Hae Kyung Im & Yongmei Liu & Heather E Wheeler - 1-21 UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling
by Hefei Zhang & Quan Zhang & Ge Gao & Xinjian Wang & Tiantian Wang & Zhitao Kong & Guoxiang Wang & Cuizhen Zhang & Yun Wang & Gang Peng