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Worldwide IP coverage of patented inventions in large pharma firms: to what extent do the internationalisation of R&D and firm strategy matter?

Author

Listed:
  • Patricia Laurens

    (LISIS - Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés - INRA - Institut National de la Recherche Agronomique - UPEM - Université Paris-Est Marne-la-Vallée - ESIEE Paris - CNRS - Centre National de la Recherche Scientifique)

  • Christian Le Bas

    (ESDES - ESDES, Lyon Business School - UCLy - UCLy - UCLy (Lyon Catholic University))

  • Antoine Schoen

    (LISIS - Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés - INRA - Institut National de la Recherche Agronomique - UPEM - Université Paris-Est Marne-la-Vallée - ESIEE Paris - CNRS - Centre National de la Recherche Scientifique)

Abstract
The paper deals with the determinants of worldwide IP coverage of patented inventions in large pharmaceutical firms. We support the core idea that the internationalisation of firm R&D and an economic presence in a foreign country are positive key factors which explains global IP coverage. For the global pharmaceutical industry, we estimate probit models on the probability that a patent will be expanded worldwide. We retain two categories of worldwide patent: the well-known triadic patent and the new triadic one (triadic + China + Korea). The data set encompasses the 17,633 priority patents applied for by 76 enterprises from several countries over the period 2003-2005. One important finding is that patenting in Japan sets up an important barrier, giving Japanese firms an advantage when triadic patenting is considered. For European and US firms, our estimation results confirm the idea that the level of firm R&D internationalisation is a significant explanatory factor in international IP coverage, together with control variables. We highlight an inverted U-shaped relationship between these two variables. The hypothesis related to a firm economic presence is also verified.

Suggested Citation

  • Patricia Laurens & Christian Le Bas & Antoine Schoen, 2019. "Worldwide IP coverage of patented inventions in large pharma firms: to what extent do the internationalisation of R&D and firm strategy matter?," Post-Print hal-01725229, HAL.
    • Handle: RePEc:hal:journl:hal-01725229
    DOI: 10.1504/IJTM.2019.100283
    Note: View the original document on HAL open archive server: https://hal.science/hal-01725229
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    References listed on IDEAS

    as
    1. de Rassenfosse, Gaetan & van Pottelsberghe de la Potterie, Bruno, 2009. "A policy insight into the R&D-patent relationship," Research Policy, Elsevier, vol. 38(5), pages 779-792, June.
    2. Oliver Gassmann & Alexander Schuhmacher & Max von Zedtwitz & Gerrit Reepmeyer, 2018. "Leading Pharmaceutical Innovation," Springer Books, Springer, edition 3, number 978-3-319-66833-8, June.
    3. Walter Kuemmerle, 1999. "The Drivers of Foreign Direct Investment into Research and Development: An Empirical Investigation," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 30(1), pages 1-24, March.
    4. Pietro Moncada-Paternò-Castello & Marco Vivarelli & Peter Voigt, 2011. "Drivers and impacts in the globalization of corporate R&D: an introduction based on the European experience," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 20(2), pages 585-603, April.
    5. Frédérique Sachwald, 2008. "Location choices within global innovation networks: the case of Europe," The Journal of Technology Transfer, Springer, vol. 33(4), pages 364-378, August.
    6. Panle Jia & Pinelopi K. Goldberg & Shubham Chaudhuri, 2006. "Estimating the Effects of Global Patent Protection in Pharmaceuticals: A Case Study of Quinolones in India," American Economic Review, American Economic Association, vol. 96(5), pages 1477-1514, December.
    7. Simona Iammarino & Philip McCann, 2013. "Multinationals and Economic Geography," Books, Edward Elgar Publishing, number 15181.
    8. Bottazzi, Giulio & Dosi, Giovanni & Lippi, Marco & Pammolli, Fabio & Riccaboni, Massimo, 2001. "Innovation and corporate growth in the evolution of the drug industry," International Journal of Industrial Organization, Elsevier, vol. 19(7), pages 1161-1187, July.
    9. Christian Sternitzke, 2009. "Defining triadic patent families as a measure of technological strength," Scientometrics, Springer;Akadémiai Kiadó, vol. 81(1), pages 91-109, October.
    10. Magazzini, Laura & Pammolli, Fabio & Riccaboni, Massimo, 2004. "Dynamic Competition in Pharmaceuticals: Patent Expiry, Generic Penetration, and Industry Structure," MPRA Paper 15968, University Library of Munich, Germany.
    11. Bas, Christian Le & Sierra, Christophe, 2002. "'Location versus home country advantages' in R&D activities: some further results on multinationals' locational strategies," Research Policy, Elsevier, vol. 31(4), pages 589-609, May.
    12. de Rassenfosse, Gaétan & Dernis, Hélène & Guellec, Dominique & Picci, Lucio & van Pottelsberghe de la Potterie, Bruno, 2013. "The worldwide count of priority patents: A new indicator of inventive activity," Research Policy, Elsevier, vol. 42(3), pages 720-737.
    13. Iain M. Cockburn & Jean O. Lanjouw & Mark Schankerman, 2016. "Patents and the Global Diffusion of New Drugs," American Economic Review, American Economic Association, vol. 106(1), pages 136-164, January.
    14. Branstetter, Lee, 2006. "Is foreign direct investment a channel of knowledge spillovers? Evidence from Japan's FDI in the United States," Journal of International Economics, Elsevier, vol. 68(2), pages 325-344, March.
    15. Kamal Saggi, 2002. "Trade, Foreign Direct Investment, and International Technology Transfer: A Survey," The World Bank Research Observer, World Bank, vol. 17(2), pages 191-235, September.
    16. Grupp, Hariolf & Schmoch, Ulrich, 1999. "Patent statistics in the age of globalisation: new legal procedures, new analytical methods, new economic interpretation," Research Policy, Elsevier, vol. 28(4), pages 377-396, April.
    17. repec:bla:jindec:v:46:y:1998:i:4:p:405-32 is not listed on IDEAS
    18. Laura Magazzini & Fabio Pammolli & Massimo Riccaboni, 2004. "Dynamic competition in pharmaceuticals," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 5(2), pages 175-182, May.
    19. Peter Neuhäusler & Rainer Frietsch, 2013. "Patent families as macro level patent value indicators: applying weights to account for market differences," Scientometrics, Springer;Akadémiai Kiadó, vol. 96(1), pages 27-49, July.
    20. Yun-Chung Chen, 2008. "Why Do Multinational Corporations Locate Their Advanced R&D Centres in Beijing?," Journal of Development Studies, Taylor & Francis Journals, vol. 44(5), pages 622-644.
    21. Patricia Laurens & Lionel Villard & Antoine Schoen & Philippe Larédo, 2018. "The artificial patents in the PATSTAT database: How much do they matter when computing indicators of internationalisation based on worldwide priority patents?," Scientometrics, Springer;Akadémiai Kiadó, vol. 114(1), pages 91-112, January.
    22. Wesley M. Cohen & Richard R. Nelson & John P. Walsh, 2000. "Protecting Their Intellectual Assets: Appropriability Conditions and Why U.S. Manufacturing Firms Patent (or Not)," NBER Working Papers 7552, National Bureau of Economic Research, Inc.
    23. Rajneesh NARULA & José GUIMÓN, 2010. "The investment development path in a globalised world: implications for Eastern Europe," Eastern Journal of European Studies, Centre for European Studies, Alexandru Ioan Cuza University, vol. 1, pages 5-19, December.
    24. John Cantwell & Simona Iammarino, 2000. "Multinational Corporations and the Location of Technological Innovation in the UK Regions," Regional Studies, Taylor & Francis Journals, vol. 34(4), pages 317-332.
    25. Bernhard Dachs & Georg Zahradnik, 2008. "Internationalisation of R&D in ICT," Springer Books, in: Huub Meijers & Bernhard Dachs & Paul J. J. Welfens (ed.), Internationalisation of European ICT Activities, chapter 0, pages 157-185, Springer.
    26. Pari Patel & Keith Pavitt, 1991. "Large Firms in the Production of the World’s Technology: An Important Case of “Non-Globalisation”," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 22(1), pages 1-21, March.
    27. Franco Malerba & Luigi Orsenigo, 2015. "The evolution of the pharmaceutical industry," Business History, Taylor & Francis Journals, vol. 57(5), pages 664-687, July.
    28. Rafols, Ismael & Hopkins, Michael M. & Hoekman, Jarno & Siepel, Josh & O'Hare, Alice & Perianes-Rodríguez, Antonio & Nightingale, Paul, 2014. "Big Pharma, little science?," Technological Forecasting and Social Change, Elsevier, vol. 81(C), pages 22-38.
    29. Sanjaya Lall, 1985. "The International Allocation of Research Activity by US Multinationals," Palgrave Macmillan Books, in: Multinationals, Technology and Exports, chapter 3, pages 38-64, Palgrave Macmillan.
    30. Jörg Mahlich, 2010. "Patents and performance in the Japanese pharmaceutical industry: An institution-based view," Asia Pacific Journal of Management, Springer, vol. 27(1), pages 99-113, March.
    31. Liu, Ming & La Croix, Sumner, 2015. "A cross-country index of intellectual property rights in pharmaceutical inventions," Research Policy, Elsevier, vol. 44(1), pages 206-216.
    32. Susanne Mundschenk & Michael H. Stierle & Ulrike Stierle-von Schütz & Iulia Traistaru, 2006. "Competitiveness and Growth in Europe: An Overview," Chapters, in: Susanne Mundschenk & Michael H. Stierle & Ulrike Stierle-von Schütz & Iulia Traistaru-Siedschlag (ed.), Competitiveness and Growth in Europe, chapter 1, Edward Elgar Publishing.
    33. Marc Baudry & Béatrice Dumont & Adriaan Dierx, 2006. "Measuring Inventive Performance of the OECD Countries Using Triadic Patent Families: Reinventing the Lisbon Challenge," Chapters, in: Susanne Mundschenk & Michael H. Stierle & Ulrike Stierle-von Schütz & Iulia Traistaru-Siedschlag (ed.), Competitiveness and Growth in Europe, chapter 9, Edward Elgar Publishing.
    34. Kjetil Bjorvatn & Carsten Eckel, 2006. "Technology Sourcing and Strategic Foreign Direct Investment," Review of International Economics, Wiley Blackwell, vol. 14(4), pages 600-614, September.
    35. Ambos, Bjorn, 2005. "Foreign direct investment in industrial research and development: A study of German MNCs," Research Policy, Elsevier, vol. 34(4), pages 395-410, May.
    36. Robert C Ronstadt, 1978. "International R & D: The Establishment and Evolution of Research and Development Abroad by Seven U.S. Multinationals," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 9(1), pages 7-24, March.
    37. von Zedtwitz, Maximilian & Gassmann, Oliver, 2002. "Market versus technology drive in R&D internationalization: four different patterns of managing research and development," Research Policy, Elsevier, vol. 31(4), pages 569-588, May.
    38. Jean O. Lanjouw & Ariel Pakes & Jonathan Putnam, 1998. "How to Count Patents and Value Intellectual Property: The Uses of Patent Renewal and Application Data," Journal of Industrial Economics, Wiley Blackwell, vol. 46(4), pages 405-432, December.
    39. Iwasa, Tomoko & Odagiri, Hiroyuki, 2004. "Overseas R&D, knowledge sourcing, and patenting: an empirical study of Japanese R&D investment in the US," Research Policy, Elsevier, vol. 33(5), pages 807-828, July.
    40. Derek Bosworth & Elizabeth Webster (ed.), 2006. "The Management of Intellectual Property," Books, Edward Elgar Publishing, volume 0, number 3649.
    41. H. Phoebe Chan, 2010. "The Determinants Of International Patenting For Nine Agricultural Biotechnology Firms," Journal of Industrial Economics, Wiley Blackwell, vol. 58(2), pages 247-278, June.
    42. Patel, Pari & Vega, Modesto, 1999. "Patterns of internationalisation of corporate technology: location vs. home country advantages1," Research Policy, Elsevier, vol. 28(2-3), pages 145-155, March.
    43. Keupp, Marcus Matthias & Friesike, Sascha & von Zedtwitz, Maximilian, 2012. "How do foreign firms patent in emerging economies with weak appropriability regimes? Archetypes and motives," Research Policy, Elsevier, vol. 41(8), pages 1422-1439.
    44. Brent B Allred & Walter G Park, 2007. "Patent rights and innovative activity: evidence from national and firm-level data," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 38(6), pages 878-900, November.
    45. Roijakkers, Nadine & Hagedoorn, John, 2006. "Inter-firm R&D partnering in pharmaceutical biotechnology since 1975: Trends, patterns, and networks," Research Policy, Elsevier, vol. 35(3), pages 431-446, April.
    46. Susanne Mundschenk & Michael H. Stierle & Ulrike Stierle-von Schütz & Iulia Traistaru-Siedschlag (ed.), 2006. "Competitiveness and Growth in Europe," Books, Edward Elgar Publishing, number 4060.
    47. Park, Walter G., 2008. "International patent protection: 1960-2005," Research Policy, Elsevier, vol. 37(4), pages 761-766, May.
    48. Keith E. Maskus, 2000. "Intellectual Property Rights in the Global Economy," Peterson Institute Press: All Books, Peterson Institute for International Economics, number 99, April.
    49. John H. Dunning & Sarianna M. Lundan, 2009. "The Internationalization of Corporate R&D: A Review of the Evidence and Some Policy Implications for Home Countries1," Review of Policy Research, Policy Studies Organization, vol. 26(1‐2), pages 13-33, January.
    50. Cantwell, John, 1995. "The Globalisation of Technology: What Remains of the Product Cycle Model?," Cambridge Journal of Economics, Cambridge Political Economy Society, vol. 19(1), pages 155-174, February.
    51. Derek Bosworth, 2006. "The Management of Intellectual Property: Introduction," Chapters, in: Derek Bosworth & Elizabeth Webster (ed.), The Management of Intellectual Property, volume 0, chapter 1, Edward Elgar Publishing.
    52. Odagiri, Hiroyuki & Yasuda, Hideto, 1996. "The determinants of overseas R&D by Japanese firms: an empirical study at the industry and company levels," Research Policy, Elsevier, vol. 25(7), pages 1059-1079, October.
    53. Hélène Dernis & Mosahid Khan, 2004. "Triadic Patent Families Methodology," OECD Science, Technology and Industry Working Papers 2004/2, OECD Publishing.
    54. Laurens, Patricia & Le Bas, Christian & Schoen, Antoine & Villard, Lionel & Larédo, Philippe, 2015. "The rate and motives of the internationalisation of large firm R&D (1994–2005): Towards a turning point?," Research Policy, Elsevier, vol. 44(3), pages 765-776.
    55. Patricia Laurens & Lionel Villard & Antoine Schoen & Philippe Larédo, 2018. "The artificial patents in the PATSTAT database: how much do they matter when computing indicators of internationalisation based on worldwide priority patents?," Post-Print hal-01671905, HAL.
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    strategy; internationalisation of R&D; pharma firms; globalisation of technology; global patent coverage;
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