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The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: An updated systematic review and meta-analysis of randomized clinical trials

Author

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  • Basel Abdelazeem
  • Joseph Shehata
  • Kirellos Said Abbas
  • Nahla Ahmed El-Shahat
  • Bilal Malik
  • Pramod Savarapu
  • Mostafa Eltobgy
  • Arvind Kunadi
Abstract
Background: Roxadustat (ROX) is a new medication for anemia as a complication of chronic kidney disease (CKD). Our meta-analysis aims to evaluate the efficacy and safety of ROX, especially on the cardiovascular risks, for anemia in NDD-CKD patients. Methods: Electronic databases were searched systematically from inception to July 2021 to look for randomized control trials (RCTs) that evaluated ROX NDD-CKD patients. Hemoglobin level and iron utilization parameters, including ferritin, serum iron, transferrin saturation (TSAT), total iron-binding capacity (TIBC), transferrin, and hepcidin were analyzed for efficacy. Pooled risk ratios (RRs) and standardized mean differences (SMDs) were calculated and presented with their 95% confidential intervals (CIs). Results: Nine RCTs included a total of 3,175 patients in the ROX group and 2,446 patients in the control group. When compared the control group, ROX increased Hb level significantly (SMD: 1.65; 95% CI: 1.08, 2.22; P

Suggested Citation

  • Basel Abdelazeem & Joseph Shehata & Kirellos Said Abbas & Nahla Ahmed El-Shahat & Bilal Malik & Pramod Savarapu & Mostafa Eltobgy & Arvind Kunadi, 2022. "The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: An updated systematic review and meta-analysis of randomized clinical trial," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0266243
    DOI: 10.1371/journal.pone.0266243
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