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Phylum Firmicutes in the Faecal Microbiota Demonstrates a Direct Association with Arterial Hypertension in Individuals of the Kazakh Population Without Insulin Resistance

Author

Listed:
  • Gulshara Abildinova

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

  • Tamara Vochshenkova

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

  • Alisher Aitkaliyev

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

  • Aizhan Abildinova

    (Municipal Polyclinic N° 9, Astana 010000, Kazakhstan)

  • Valeriy Benberin

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan
    CF «Institute of Innovative and Preventive Medicine», Alikhan Bokeikhan Street, Building 1, Astana 010000, Kazakhstan)

  • Anna Borovikova

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

  • Nazira Bekenova

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

  • Balzhan Kassiyeva

    (Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, Kazakhstan)

Abstract
The gut microbiota plays a fundamental role in the host’s energy metabolism and the development of metabolic diseases such as arterial hypertension, insulin resistance, and atherosclerosis. Our study aimed to investigate the potential role of the gut microbiota in arterial hypertension among individuals of the Kazakh population without insulin resistance. 16S rRNA gene sequencing of faecal samples from 197 Kazakh subjects was performed. Preliminary binary comparisons of the faecal microbiota composition depending on the presence of arterial hypertension and insulin resistance revealed statistically significant differences in the abundance of the phylum Firmicutes . Logistic regression analysis showed that only the phylum Firmicutes influenced hypertension risk in individuals without insulin resistance after adjusting for age, sex, BMI, fasting glucose, triglycerides, and triglyceride–glucose index. The higher the abundance of the phylum Firmicutes in faeces, the greater the risk of arterial hypertension (OR = 1.064 [95% CI 1.005–1.125]). Correlation analysis revealed a negative association between the abundance of the phylum Firmicutes and the triglyceride–glucose index, primarily driven by triglyceride levels. These findings suggest the potential role of the gut microbiota, especially the phylum Firmicutes , in the development of hypertension in individuals without insulin resistance.

Suggested Citation

  • Gulshara Abildinova & Tamara Vochshenkova & Alisher Aitkaliyev & Aizhan Abildinova & Valeriy Benberin & Anna Borovikova & Nazira Bekenova & Balzhan Kassiyeva, 2024. "Phylum Firmicutes in the Faecal Microbiota Demonstrates a Direct Association with Arterial Hypertension in Individuals of the Kazakh Population Without Insulin Resistance," IJERPH, MDPI, vol. 21(12), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:12:p:1546-:d:1526817
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