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Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic

Author

Listed:
  • Carlos André Freitas dos Santos

    (Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil)

  • Ariane Nardy

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Renato Jimenez Gomes

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Brenda Rodrigues Silva

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Fernanda Rodrigues Monteiro

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Marcelo Rossi

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Jônatas Bussador do Amaral

    (ENT Research Laboratory, Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Vitória Paixão

    (ENT Research Laboratory, Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Mauro Walter Vaisberg

    (ENT Research Laboratory, Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Gislene Rocha Amirato

    (Mane Garrincha Sports Education Center, Sports Department of the Municipality of Sao Paulo (SEME), São Paulo 04039-034, Brazil)

  • Rodolfo P. Vieira

    (Post-Graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos 11010-150, Brazil
    Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangelica), Anápolis 75083-515, Brazil)

  • Juliana de Melo Batista dos Santos

    (Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo 05360-000, Brazil)

  • Guilherme Eustaquio Furtado

    (Polytechnic Institute of Coimbra, Applied Research Institute, 3045-093 Coimbra, Portugal
    SPRINT Sport Physical Activity and Health Research & Innovation Center, Polytechnic University of Coimbra, 3045-601 Coimbra, Portugal
    Center for Studies on Natural Resources, Environment, and Society (CERNAS), Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal)

  • Ana Paula Ribeiro

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Patrícia Colombo-Souza

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Alessandro Ferrari Jacinto

    (Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil
    These authors contributed equally to this work.)

  • Andre Luis Lacerda Bachi

    (Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil
    These authors contributed equally to this work.)

Abstract
Background: Inflammaging and physical performance were investigated in older adults before and after the COVID-19 pandemic. Methods: Older women ( n = 18) and men ( n = 7) (mean age = 73.8 ± 7.1) were evaluated before the COVID-19 pandemic (PRE), 12 months after the lockdown (POST), and 10 months after resuming exercise training (POST-TR). Physical tests [gait speed (GS) and timed-up-and-go (TUG)]; muscle strength (handgrip—HG); and serum cytokine levels were assessed. Results: Older women showed higher GS and TUG at POST than PRE and POST-TR but lower HG at POST-TR than PRE, whereas older men exhibited lower HG at POST and POST-TR than PRE. Both groups presented (1) lower IL-10 and IL-12p70 values in contrast to higher IL-6/IL-10 and IL-8/IL-10 ratios at POST than PRE; (2) higher IL-10 values and lower IL-8/IL-10 ratio at POST-TR than POST; (3) higher IL-12p70/IL-10 ratio at POST-TR than PRE and POST. Particularly, older women showed (4) lower IL-6 values at POST and POST-TR than PRE; (5) lower IL-8 and IL-10 values at POST-TR than POST; (6) and higher TNF-α/IL-10 and IFN-γ/IL-10 ratios at POST than PRE and POST-TR. Significant correlations between the variables were found in both groups. Discussion: During the COVID-19 pandemic, detraining and resumption of exercise training promoted distinct alterations in physical capacity and inflammaging among older women and older men.

Suggested Citation

  • Carlos André Freitas dos Santos & Ariane Nardy & Renato Jimenez Gomes & Brenda Rodrigues Silva & Fernanda Rodrigues Monteiro & Marcelo Rossi & Jônatas Bussador do Amaral & Vitória Paixão & Mauro Walte, 2024. "Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic," IJERPH, MDPI, vol. 21(11), pages 1-17, October.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:11:p:1425-:d:1507624
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    References listed on IDEAS

    as
    1. Achraf Ammar & Omar Boukhris & Nicole Halfpaap & Berit Kristin Labott & Corinna Langhans & Fabian Herold & Bernhard Grässler & Patrick Müller & Khaled Trabelsi & Hamdi Chtourou & Piotr Zmijewski & Tar, 2021. "Four Weeks of Detraining Induced by COVID-19 Reverse Cardiac Improvements from Eight Weeks of Fitness-Dance Training in Older Adults with Mild Cognitive Impairment," IJERPH, MDPI, vol. 18(11), pages 1-19, May.
    2. Seung-Jae Heo & Sang-Kyun Park & Yong-Seok Jee, 2022. "Detraining Effects of COVID-19 Pandemic on Physical Fitness, Cytokines, C-Reactive Protein and Immunocytes in Men of Various Age Groups," IJERPH, MDPI, vol. 19(3), pages 1-15, February.
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