[go: up one dir, main page]
IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i3p270-d92415.html
   My bibliography  Save this article

Long Non-Coding RNA as Potential Biomarker for Prostate Cancer: Is It Making a Difference?

Author

Listed:
  • Junli Deng

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Jie Tang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Guo Wang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Yuan-Shan Zhu

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
    Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA)

Abstract
Whole genome transcriptomic analyses have identified numerous long non-coding RNA (lncRNA) transcripts that are increasingly implicated in cancer biology. LncRNAs are found to promote essential cancer cell functions such as proliferation, invasion, and metastasis, with the potential to serve as novel biomarkers of various cancers and to further reveal uncharacterized aspects of tumor biology. However, the biological and molecular mechanisms as well as the clinical applications of lncRNAs in diverse diseases are not completely understood, and remain to be fully explored. LncRNAs may be critical players and regulators in prostate cancer carcinogenesis and progression, and could serve as potential biomarkers for prostate cancer. This review focuses on lncRNA biomarkers that are already available for clinical use and provides an overview of lncRNA biomarkers that are under investigation for clinical development in prostate cancer.

Suggested Citation

  • Junli Deng & Jie Tang & Guo Wang & Yuan-Shan Zhu, 2017. "Long Non-Coding RNA as Potential Biomarker for Prostate Cancer: Is It Making a Difference?," IJERPH, MDPI, vol. 14(3), pages 1-16, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:270-:d:92415
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/3/270/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/3/270/
    Download Restriction: no
    ---><---

    More about this item

    Keywords

    prostate cancer; lncRNAs; PCA3; biomarkers;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:270-:d:92415. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.