[go: up one dir, main page]
IDEAS home Printed from https://ideas.repec.org/a/gam/jdataj/v9y2024i9p107-d1479685.html
   My bibliography  Save this article

OSBA: An Open Neonatal Neuroimaging Atlas and Template for Spina Bifida Aperta

Author

Listed:
  • Anna Speckert

    (Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zurich, 8057 Zurich, Switzerland)

  • Hui Ji

    (Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Kelly Payette

    (Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Patrice Grehten

    (Department of Diagnostic Imaging, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    The Zurich Center for Fetal Diagnosis and Therapy, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Raimund Kottke

    (Department of Diagnostic Imaging, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    The Zurich Center for Fetal Diagnosis and Therapy, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Samuel Ackermann

    (Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Beth Padden

    (Division of Pediatric Rehabilitation, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Zurich Center for Spina Bifida, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Luca Mazzone

    (Zurich Center for Spina Bifida, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Department of Pediatric Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland)

  • Ueli Moehrlen

    (Zurich Center for Spina Bifida, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Department of Pediatric Surgery, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland)

  • Spina Bifida Study Group Zurich

    (Spina Bifida Study Group Zurich, Zurich, Switzerland
    All members are listed in the Acknowledgements section.)

  • Andras Jakab

    (Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
    University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zurich, 8057 Zurich, Switzerland
    Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland)

Abstract
We present the Open Spina Bifida Aperta (OSBA) atlas, an open atlas and set of neuroimaging templates for spina bifida aperta (SBA). Traditional brain atlases may not adequately capture anatomical variations present in pediatric or disease-specific cohorts. The OSBA atlas fills this gap by representing the computationally averaged anatomy of the neonatal brain with SBA after fetal surgical repair. The OSBA atlas was constructed using structural T2-weighted and diffusion tensor MRIs of 28 newborns with SBA who underwent prenatal surgical correction. The corrected gestational age at MRI was 38.1 ± 1.1 weeks (mean ± SD). The OSBA atlas consists of T2-weighted and fractional anisotropy templates, along with nine tissue prior maps and region of interest (ROI) delineations. The OSBA atlas offers a standardized reference space for spatial normalization and anatomical ROI definition. Our image segmentation and cortical ribbon definition are based on a human-in-the-loop approach, which includes manual segmentation. The precise alignment of the ROIs was achieved by a combination of manual image alignment and automated, non-linear image registration. From the clinical and neuroimaging perspective, the OSBA atlas enables more accurate spatial standardization and ROI-based analyses and supports advanced analyses such as diffusion tractography and connectomic studies in newborns affected by this condition.

Suggested Citation

  • Anna Speckert & Hui Ji & Kelly Payette & Patrice Grehten & Raimund Kottke & Samuel Ackermann & Beth Padden & Luca Mazzone & Ueli Moehrlen & Spina Bifida Study Group Zurich & Andras Jakab, 2024. "OSBA: An Open Neonatal Neuroimaging Atlas and Template for Spina Bifida Aperta," Data, MDPI, vol. 9(9), pages 1-13, September.
    • Handle: RePEc:gam:jdataj:v:9:y:2024:i:9:p:107-:d:1479685
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2306-5729/9/9/107/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2306-5729/9/9/107/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jdataj:v:9:y:2024:i:9:p:107-:d:1479685. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.