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Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age

Author

Listed:
  • Baker, Samuel

    (University of Bristol)

  • Biroli, Pietro

    (University of Bologna)

  • van Kippersluis, Hans

    (Erasmus University Rotterdam)

  • von Hinke, Stephanie

    (University of Bristol)

Abstract
Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond (1986) show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s. We go 'beyond Barker', first by showing that this relationship is robust to the inclusion of local geographic area fixed effects, but not family fixed effects. Second, we explore whether the average effects conceal underlying heterogeneity: we examine if the infant mortality effect offsets or reinforces one's genetic predisposition for heart disease. We find considerable heterogeneity that is robust to within-area as well as within-family analyses. Our findings show that the effects of one's early life environments mainly affect individuals with the highest genetic risk for developing heart disease. Put differently, in areas with the lowest infant mortality rates, the effect of one's genetic predisposition effectively vanishes. These findings suggests that advantageous environments can cushion one's genetic risk of developing heart disease.

Suggested Citation

  • Baker, Samuel & Biroli, Pietro & van Kippersluis, Hans & von Hinke, Stephanie, 2022. "Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age," IZA Discussion Papers 15291, Institute of Labor Economics (IZA).
    • Handle: RePEc:iza:izadps:dp15291
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    References listed on IDEAS

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    Cited by:

    1. Rita Dias Pereira & Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Cornelius A. Rietveld & Kevin Thom, 2022. "Gene-Environment Interplay in the Social Sciences," Papers 2203.02198, arXiv.org, revised Aug 2022.
    2. Costa, Dora L., 2023. "Overweight grandsons and grandfathers’ starvation exposure," Journal of Health Economics, Elsevier, vol. 91(C).

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    More about this item

    Keywords

    gene-environment interplay; developmental origins; Barker hypothesis;
    All these keywords.

    JEL classification:

    • I10 - Health, Education, and Welfare - - Health - - - General
    • I14 - Health, Education, and Welfare - - Health - - - Health and Inequality
    • I19 - Health, Education, and Welfare - - Health - - - Other

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