Lihat sumber Famsiklovir

Anda tidak memiliki hak akses untuk menyunting halaman ini, karena alasan berikut:

Your IP address is in a range that has been blocked on all Wikimedia Foundation wikis.

The block was made by ‪Hasley‬. The reason given is Open proxy/Webhost: See the help page if you are affected: .

Start of block: 18 Desember 2022 16.21
Expiry of block: 18 Desember 2025 16.21

Your current IP address is 62.210.136.28. The blocked range is 62.210.0.0/16.

Harap sertakan semua perincian di atas dalam setiap pertanyaan yang Anda ajukan. If you believe you were blocked by mistake, you can find additional information and instructions in the No open proxies global policy.

Otherwise, to discuss the block please post a request for review on Meta-Wiki. You could also send an email to the stewards VRT queue at stewards@wikimedia.org including all above details.

Anda dapat melihat atau menyalin sumber halaman ini.

{{Drugbox
| verifiedrevid = 461098816
| image = Famciclovir.svg
| width = 225
| alt = 

<!-- Clinical data -->
| tradename = Famvir
| pronounce = {{IPAc-en|ˌ|f|æ|m|ˈ|s|aɪ|k|l|oʊ|ˌ|v|ɪər}}{{refn|{{MerriamWebsterDictionary|access-date=2016-01-22|Famciclovir}}}}
| Drugs.com = {{drugs.com|monograph|famciclovir}}
| MedlinePlus = a694038
| pregnancy_AU = B1
| pregnancy_category =
| routes_of_administration = Oral
| ATC_prefix = J05
| ATC_suffix = AB09
| ATC_supplemental =  {{ATC|S01|AD07}}

| legal_AU = S4
| legal_AU_comment = <ref>{{cite web | title=Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017 | website=Therapeutic Goods Administration (TGA) | date=21 June 2022 | url=https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017 | access-date=30 March 2024}}</ref>
| legal_CA =
| legal_UK = POM
| legal_US = Rx-only
| legal_status =

<!--Pharmacokinetic data-->
| bioavailability = 75–77%
| protein_bound = 20–25%
| metabolism = Hati, sirkulasi, dinding usus (hingga pensiklovir)
| elimination_half-life = 2–2,3 jam
| excretion = [[Ginjal]], feses

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 104227-87-4
| PubChem = 3324
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00426
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3207
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = QIC03ANI02
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00317
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 4974
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 880

<!-- Chemical data -->
| IUPAC_name = 2-[(asetiloksi)metil]-4-(2-amino-9''H''-purin-9-il)butil asetat
| C=14 | H=19 | N=5 | O=4
| smiles = O=C(OCC(COC(=O)C)CCn1c2nc(ncc2nc1)N)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GGXKWVWZWMLJEH-UHFFFAOYSA-N
| melting_point = 103
}}

'''Famsiklovir''' adalah [[obat antivirus]] analog guanosin yang digunakan untuk pengobatan berbagai infeksi [[virus herpes]], paling umum untuk [[herpes zoster]] (cacar ular). Obat ini adalah bentuk [[bakal obat]] [[pensiklovir]] dengan [[bioavailabilitas]] oral yang lebih baik. 

Famsiklovir dipatenkan pada tahun 1983 dan disetujui untuk penggunaan medis pada tahun 1994.<ref>{{cite book| vauthors =  Long SS, Pickering LK, Prober CG |title=Principles and Practice of Pediatric Infectious Disease|date=2012|publisher=Elsevier Health Sciences|isbn=978-1437727029|page=1502 |url=https://books.google.com/books?id=nQ7-o8JAH7kC&pg=PA1502 }}</ref><ref name=Fis2006>{{cite book | vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=504 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA504 |language=en}}</ref> Pada tahun 2007, [[Badan Pengawas Obat dan Makanan Amerika Serikat]] menyetujui famsiklovir versi generik pertama. Tablet generik diproduksi oleh [[Teva Pharmaceutical Industries|TEVA Pharmaceuticals]] dan [[Mylan]] Pharmaceuticals.<ref>{{cite web| url=http://www.tevausa.com/default.aspx?pageid=75| title=Recent Product Launches, Teva Pharmaceuticals USA| access-date=2008-02-21| archive-url= https://web.archive.org/web/20111108014430/http://www.tevausa.com/default.aspx?pageid=75| archive-date=2011-11-08| url-status=dead}}{{better source|date=March 2016}}</ref><ref>{{cite press release|title=Mylan Launches Generic Version of Famvir® Tablets |publisher=Mylan |date=20 April 2011 |url=http://investor.mylan.com/releasedetail.cfm?ReleaseID=570428 |access-date=21 April 2011 |url-status=dead |archive-url=https://web.archive.org/web/20110723062658/http://investor.mylan.com/releasedetail.cfm?ReleaseID=570428 |archive-date=July 23, 2011 }}</ref>

==Kegunaan dalam Medis==
Famsiklovir diindikasikan untuk pengobatan herpes zoster,<ref name=Tyring1995>{{cite journal | vauthors = Tyring S, Barbarash RA, Nahlik JE, Cunningham A, Marley J, Heng M, Jones T, Rea T, Boon R, Saltzman R | display-authors = 6 | title = Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group | journal = Annals of Internal Medicine | volume = 123 | issue = 2 | pages = 89–96 | date = July 1995 | pmid = 7778840 | doi = 10.7326/0003-4819-123-2-199507150-00002 | s2cid = 35498460 }}</ref> pengobatan virus [[herpes simpleks]] 2 (herpes genital),<ref name=Luber1995>{{cite journal | vauthors = Luber AD, Flaherty JF | title = Famciclovir for treatment of herpesvirus infections | journal = The Annals of Pharmacotherapy | volume = 30 | issue = 9 | pages = 978–85 | date = September 1996 | pmid = 8876860 | doi = 10.1177/106002809603000913 | s2cid = 27057728 }}</ref> [[Herpes oral|herpes labialis]] (luka dingin) pada pasien imunokompeten<ref name=Spraunce2006>{{cite journal | vauthors = Spruance SL, Bodsworth N, Resnick H, Conant M, Oeuvray C, Gao J, Hamed K | title = Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis | journal = Journal of the American Academy of Dermatology | volume = 55 | issue = 1 | pages = 47–53 | date = July 2006 | pmid = 16781291 | doi = 10.1016/j.jaad.2006.02.031 }}</ref> dan untuk menekan episode berulang virus herpes simpleks 2. Obat ini juga diindikasikan untuk pengobatan episode herpes simpleks berulang pada pasien HIV.{{cn|date=November 2022}}

==Efek Samping==
Efek sampingnya berupa sakit perut ringan sampai ekstrim, sakit kepala, dan demam ringan.

==Penelitian==
===Perawatan Dini=== 
Beberapa penelitian pada manusia dan tikus memberikan bukti bahwa pengobatan dini dengan famsiklovir segera setelah infeksi herpes pertama dapat secara signifikan menurunkan kemungkinan wabah di masa depan. Penggunaan famsiklovir dengan cara ini telah terbukti mengurangi jumlah [[virus]] laten di ganglia saraf dibandingkan tanpa pengobatan atau pengobatan dengan [[valasiklovir]].<ref name="pmid10993926">{{cite journal | vauthors = Thackray AM, Field HJ | title = The effects of antiviral therapy on the distribution of herpes simplex virus type 1 to ganglionic neurons and its consequences during, immediately following and several months after treatment | journal = The Journal of General Virology | volume = 81 | issue = Pt 10 | pages = 2385–2396 | date = October 2000 | pmid = 10993926 | doi = 10.1099/0022-1317-81-10-2385 | doi-access = free }}</ref><ref name="pmid9660982">{{cite journal | vauthors = Thackray AM, Field HJ | title = Famciclovir and valaciclovir differ in the prevention of herpes simplex virus type 1 latency in mice: a quantitative study | journal = Antimicrobial Agents and Chemotherapy | volume = 42 | issue = 7 | pages = 1555–62 | date = July 1998 | pmid = 9660982 | pmc = 105644 | doi = 10.1128/AAC.42.7.1555}}</ref><ref name="pmid10602729">{{cite journal | vauthors = Thackray AM, Field HJ | title = Persistence of infectious herpes simplex virus type 2 in the nervous system in mice after antiviral chemotherapy | journal = Antimicrobial Agents and Chemotherapy | volume = 44 | issue = 1 | pages = 97–102 | date = January 2000 | pmid = 10602729 | pmc = 89634 | doi = 10.1128/aac.44.1.97-102.2000 }}</ref> Sebuah tinjauan terhadap subyek manusia yang diobati selama lima hari dengan famsiklovir 250 mg tiga kali sehari selama episode herpes pertama mereka menemukan bahwa hanya 4,2 persen mengalami kekambuhan dalam waktu enam bulan setelah wabah pertama, penurunan lima kali lipat dibandingkan dengan kekambuhan sebesar 19 persen pada pasien yang diobati dengan asiklovir.<ref>{{cite web | title = Observation May Indicate A Possible Clinical Effect On Latency | url = http://www.pslgroup.com/dg/D29E.htm | work = Doctor's Guide Publishing Limited | archive-url = https://web.archive.org/web/20120216215210/http://www.pslgroup.com/dg/D29E.htm | archive-date = 2012-02-16 }}</ref> Tidak ada obat yang mempengaruhi latensi jika pengobatan ditunda selama beberapa bulan.<ref name=Thackray>{{cite journal | vauthors = Thackray AM, Field HJ | title = Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency | journal = The Journal of Infectious Diseases | volume = 173 | issue = 2 | pages = 291–9 | date = February 1996 | pmid = 8568288 | doi = 10.1093/infdis/173.2.291 | doi-access = free }}</ref>

==Referensi==
{{Reflist}}
[[Kategori:Antivirus herpes]]
[[Kategori:Bakal obat]]
[[Kategori:Obat yang dikembangkan oleh Schering-Plough]]
[[Kategori:Purina]]
[[Kategori:Ester asetat]]
[[Kategori:Obat yang dikembangkan oleh Novartis]]

Templat yang digunakan di halaman ini:

Templat:ATC (sunting)
Templat:Better source (sunting)
Templat:Butuh rujukan (lihat sumber) (dilindungi)
Templat:Butuh sumber yang lebih baik (sunting)
Templat:Cascite (sunting)
Templat:Centang (sunting)
Templat:Chemspidercite (sunting)
Templat:Cite book (lihat sumber) (dilindungi)
Templat:Cite journal (lihat sumber) (dilindungi)
Templat:Cite press release (lihat sumber) (semi-dilindungi)
Templat:Cite web (lihat sumber) (dilindungi)
Templat:Cn (sunting)
Templat:Collapsible list (sunting)
Templat:Cross (sunting)
Templat:Drugbox (sunting)
Templat:Drugs.com (sunting)
Templat:Ebicite (sunting)
Templat:Fdacite (sunting)
Templat:Fix (lihat sumber) (dilindungi)
Templat:Infobox drug (sunting)
Templat:Keggcite (sunting)
Templat:Main other (lihat sumber) (dilindungi)
Templat:OrganicBox (sunting)
Templat:OrganicBox atom (sunting)
Templat:Px (sunting)
Templat:Reflist (lihat sumber) (dilindungi)
Templat:Reflist/styles.css (lihat sumber) (dilindungi)
Templat:Silang (sunting)
Templat:Stdinchicite (sunting)
Templat:Tick (sunting)
Templat:Unicode (sunting)
Modul:Check for unknown parameters (lihat sumber) (dilindungi)
Modul:Citation/CS1 (lihat sumber) (dilindungi)
Modul:Citation/CS1/COinS (lihat sumber) (dilindungi)
Modul:Citation/CS1/Configuration (lihat sumber) (dilindungi)
Modul:Citation/CS1/Date validation (lihat sumber) (dilindungi)
Modul:Citation/CS1/Identifiers (lihat sumber) (dilindungi)
Modul:Citation/CS1/Suggestions (sunting)
Modul:Citation/CS1/Utilities (lihat sumber) (dilindungi)
Modul:Citation/CS1/Whitelist (lihat sumber) (dilindungi)
Modul:Collapsible list (lihat sumber) (dilindungi)
Modul:Unsubst (lihat sumber) (dilindungi)

Kembali ke Famsiklovir.

Diperoleh dari "https://id.wikipedia.org/wiki/Famsiklovir"