Tronbina

Tronbina
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
Identifikatzaileak
Aliasak	F2 (HUGO), PT, RPRGL2, THPH1, coagulation factor II, thrombin
Kanpoko IDak	OMIM: 176930 MGI: 88380 HomoloGene: 426 GeneCards: F2 OMA: F2 - orthologs
Genetikoki lotutako gaixotasunak
	hypoprothrombinemia , hiperkoagulazio
Drogaren xedea
	dabigatran , ximelagatran , dabigatran etexilate , argatroban
Genearen kokapena (gizakia)
	Kromosoma: 11 (gizakia)
Amaiera	46.739.506 bp
Genearen kokapena (sagua)
	Kromosoma: 2 (sagua)
Amaiera	91.466.759 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	right lobe of liver ; ; Barrabil; ; obozito; ; secondary oocyte ; ; cerebellar hemisphere ; ; right hemisphere of cerebellum ; ; popliteal artery ; ; Tibial arteries ; ; fundus ; ; enbrioi;
	Adierazpen ohikoena
	left lobe of liver ; ; fetal liver hematopoietic progenitor cell ; ; Behazun xixku; ; Zaku bitelino; ; umeki; ; sexually immature organism ; ; morula ; ; primary oocyte ; ; secondary oocyte ; ; zigoto;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	kaltzio ioi lotura ; signaling receptor binding ; peptidase activity ; hydrolase activity ; growth factor activity ; serine-type peptidase activity ; thrombospondin receptor activity ; proteina lotura ; serine-type endopeptidase activity ; lipopolysaccharide binding ; heparin binding ; enzyme activator activity ;
Zelularen osagaia	extracellular exosome ; blood microparticle ; endoplasmic reticulum lumen ; Golgi lumen ; zelula mintz ; zelulaz kanpoko eremu ; extracellular space ; external side of plasma membrane ; collagen-containing extracellular matrix ;
Prozesu biologikoa	blood coagulation, intrinsic pathway ; regulation of blood coagulation ; positive regulation of phosphatidylinositol 3-kinase signaling ; positive regulation of collagen biosynthetic process ; izaki zelulanitzen garapena ; peptidyl-glutamic acid carboxylation ; acute-phase response ; positive regulation of reactive oxygen species metabolic process ; endoplasmic reticulum to Golgi vesicle-mediated transport ; positive regulation of cell growth ; cell surface receptor signaling pathway ; gene-erregulazio ; positive regulation of release of sequestered calcium ion into cytosol ; positive regulation of cell population proliferation ; leukocyte migration ; negative regulation of fibrinolysis ; positive regulation of blood coagulation ; regulation of cytosolic calcium ion concentration ; response to wounding ; signal peptide processing ; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ; regulation of cell shape ; Hemostasi ; negative regulation of proteolysis ; negative regulation of platelet activation ; negative regulation of astrocyte differentiation ; positive regulation of protein phosphorylation ; Fibrinolisi ; Gatzapen ; proteolisi ; platelet activation ; positive regulation of protein localization to nucleus ; positive regulation of lipid kinase activity ; regulation of complement activation ; antimicrobial humoral immune response mediated by antimicrobial peptide ; negative regulation of cytokine production involved in inflammatory response ; regulation of signaling receptor activity ; G proteina errezeptore akoplatuaren komunikazio bidea ; positive regulation of receptor signaling pathway via JAK-STAT ; blood coagulation, fibrin clot formation ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	2147
	14061
	ENSG00000180210
	ENSMUSG00000027249
	P00734
	P19221
	NM_000506; NM_001311257
	NM_010168
	NP_000497
	NP_034298
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Tronbina odolaren gatzapen prozesuan parte hartzen duen funtsezko entzima da. Prozesu horretan fibrinogeno izeneko proteina disolbagarria fibrina izeneko proteina disolbaezina bihurtzen da, tronbina izanik bilakaera hori katalizatzen duen entzima.

Fibrinogeno → Fibrina

Tronbina 36 eta 259 aminoazido dituzten bi kate polipeptidikoz osaturik dago. Bi kate horiek lotura disulfurikoen bidez elkarturik daude.

Tronbina protronbina izeneko molekula batetik sortzen da. Bilakaera horretan parte hartzen duen entzima tronboplastina da, odoleko plaketek askatzen dutena odol-hodi batek kalte handia jasotzen duenean. Tronbina sortzeko prozesuan K bitaminak eta kaltzio ioiek funtsezko zeregina burutzen dute.

Tronbinari esker sortzen den fibrina odol-koaguluaren sortzailea da, odoljarioak ekiditen dituena.

Erreferentziak

↑ Genetikoki lotutako gaixotasunak Tronbinaikusi/editatu erreferentziak Wikidatan. .
↑ Fisikoki elkarreragiten duten drogak Tronbinaikusi/editatu erreferentziak Wikidatan. .
↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180210 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027249 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

Kanpo estekak

Datuak: Q409166
Multimedia: Thrombin / Q409166

[1] Genetikoki lotutako gaixotasunak Tronbinaikusi/editatu erreferentziak Wikidatan. .

[2] Fisikoki elkarreragiten duten drogak Tronbinaikusi/editatu erreferentziak Wikidatan. .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000180210 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000027249 – Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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