Interleuzina 2

IL2
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Identifikatzaileak
Aliasak	IL2 (HUGO), IL-2, TCGF, lymphokine, interleukin 2
Kanpoko IDak	OMIM: 147680   MGI: 96548   HomoloGene: 488   GeneCards: IL2   OMA: IL2 - orthologs
Genetikoki lotutako gaixotasunak
Alergia, 1. motako diabetes mellitus [1]
Genearen kokapena (gizakia) Kromosoma: 4 (gizakia)[2] Banda 4q27 Hasiera 122.451.470 bp[2] Amaiera 122.456.725 bp[2]
Genearen kokapena (sagua) Kromosoma: 3 (sagua)[3] Banda 3 B|3 18.3 cM Hasiera 37.174.672 bp[3] Amaiera 37.180.108 bp[3]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena Gonada Barrabil gongoil linfatiko Heste sobre granulozito ondeste Duodeno Behazun xixku Bare eskumako birika  Adierazpen ohikoena faringe espermatida  ganglionic eminence  Duodeno Hestegorri foregut  Urdail blastocyst  spermatocyte  ventricular zone  Erreferentziazko adierazpen datu gehiago BioGPS Erreferentziazko adierazpen datu gehiago
Gene ontologia Funtzio molekularra cytokine activity  interleukin-2 receptor binding  glycosphingolipid binding  kinase activator activity  growth factor activity  kappa-type opioid receptor binding  carbohydrate binding  proteina lotura  Zelularen osagaia zelulaz kanpoko eremu  intrazelular  extracellular space  Prozesu biologikoa positive regulation of T cell differentiation  negative regulation of protein phosphorylation  G proteina errezeptore akoplatuaren komunikazio bidea  positive regulation of protein phosphorylation  positive regulation of inflammatory response  adaptive immune response  negative regulation of heart contraction  immune system process  positive regulation of cytosolic calcium ion concentration  positive regulation of regulatory T cell differentiation  cell-cell signaling  positive regulation of interferon-gamma production  natural killer cell activation  negative regulation of apoptotic process  positive regulation of dendritic spine development  negative regulation of lymphocyte proliferation  MAPK cascade  regulation of T cell homeostatic proliferation  T cell differentiation  positive regulation of cell growth  protein kinase C-activating G protein-coupled receptor signaling pathway  Atxikipen zelular  positive regulation of B cell proliferation  positive regulation of tissue remodeling  positive regulation of T cell proliferation  erantzun immune  positive regulation of cell population proliferation  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of B cell apoptotic process  positive regulation of isotype switching to IgG isotypes  positive regulation of interleukin-17 production  response to ethanol  negative regulation of inflammatory response  RNA polimerasa II-tik transkripzioaren erregulazio positiboaren bultzatzaile  positive regulation of activated T cell proliferation  negative regulation of T-helper 17 cell differentiation  leukocyte activation involved in immune response  positive regulation of tyrosine phosphorylation of STAT protein  regulation of regulatory T cell differentiation  regulation of signaling receptor activity  cytokine-mediated signaling pathway  interleukin-2-mediated signaling pathway  positive regulation of kinase activity  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 3558 16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (RNAm) NM_000586 NM_008366 RefSeq (proteina) NP_000577 NP_032392 Kokapena (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed bilaketa [4] [5]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

Interleuzina-2 (IL-2) interleuzina bat da, immunitate sistemako seinaleztatze zitokina motako molekula bat. 15.5–16 kDa dituen proteina bat da^[6], leukozitoen jarduera erregulatzen duena. Zelula horiek dira immunitatearen arduradun. IL-2 gorputzak mikrobioen infekzioen aurrean duen erantzun naturalaren parte da, eta bere arduretako bat da kanpoko ("norbera ez") eta "norbera" bereiztea. IL-2k bere efektua egiten du IL-2 errezeptoreei lotuta, linfozitoetan agertzen direnak. IL-2ren iturri nagusiak CD4+ T linfozito aktibatuak eta CD8+ T linfozito aktibatuak dira^[7].