TNFAIP8

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Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene.^[5]^[6]^[7] It is preferentially expressed in human immune cell types.^[8]

TNFAIP8

Identifiers

TNFAIP8, GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8

External IDs

OMIM: 612111; MGI: 2147191; HomoloGene: 8649; GeneCards: TNFAIP8; OMA:TNFAIP8 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q23.1	Start	119,268,692 bp^[1]
Band	5q23.1	End	119,399,688 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 D1	Start	50,112,494 bp^[2]
Band	18\|18 D1	End	50,240,240 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

epithelium of nasopharynx

appendix

bone marrow

white blood cell

mononuclear cell

monocyte

lymph node

bone marrow cells

trabecular bone

Top expressed in

gastrula

right kidney

granulocyte

decidua

thymus

human kidney

primary oocyte

spleen

conjunctival fornix

myocardium of ventricle

More reference expression data


More reference expression data

Gene ontology
Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding
Cellular component	cytoplasm nucleoplasm
Biological process	negative regulation of apoptotic process apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of apoptotic process regulation of apoptotic process
Sources:Amigo / QuickGO

Species

Human

Mouse


25816


106869


ENSG00000145779


ENSMUSG00000062210


O95379


Q921Z5

RefSeq (mRNA)

NM_014350 NM_001077654 NM_001286813 NM_001286814 NM_001286815
NM_001286817


NM_001177759 NM_001177760 NM_134131 NM_001360935

RefSeq (protein)

NP_001071122 NP_001273742 NP_001273743 NP_001273744 NP_001273746
NP_055165


NP_001171230 NP_001171231 NP_598892 NP_001347864

Location (UCSC)

Chr 5: 119.27 – 119.4 Mb

Chr 18: 50.11 – 50.24 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145779 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062210 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
^ Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi:10.1074/jbc.275.4.2973. PMID 10644768.
^ "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".
^ Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Kumar D, Gokhale P, Broustas C, et al. (2004). "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells". Oncogene. 23 (2): 612–6. doi:10.1038/sj.onc.1207123. PMID 14724590.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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