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Ro 3-0412

Ro 3-0412 is an acetylcholinesterase inhibitor. It is the organophosphate analog of neostigmine.[1]

Ro 3-0412
Names
Preferred IUPAC name
3-[(Dimethoxyphosphoryl)oxy]-N,N,N-trimethylanilinium methyl sulfate
Other names
Dimethylphosphostigmine
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C11H19NO4P.CH4O4S/c1-12(2,3)10-7-6-8-11(9-10)16-17(13,14-4)15-5;1-5-6(2,3)4/h6-9H,1-5H3;1H3,(H,2,3,4)/q+1;/p-1
    Key: SEPBMCLYOUSLFT-UHFFFAOYSA-M
  • C[N+](C)(C)c1cccc(c1)OP(=O)(OC)OC.COS(=O)(=O)[O-]
Properties
C12H22NO8PS
Molar mass 371.34 g·mol−1
Hazards
Lethal dose or concentration (LD, LC):
0.57 mg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

See also

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References

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  1. ^ BURGEN, AS; HOBBIGER, F (December 1951). "The inhibition of cholinesterases by alkyl-phosphates and alkylphenolphosphates". British Journal of Pharmacology and Chemotherapy. 6 (4): 593–605. doi:10.1111/j.1476-5381.1951.tb00670.x. PMC 1509150. PMID 14904884.
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