There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]
- parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
- parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]
| parathyroid hormone 1 receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTH1R | ||||||
| Alt. symbols | PTHR, PFE | ||||||
| NCBI gene | 5745 | ||||||
| HGNC | 9608 | ||||||
| OMIM | 168468 | ||||||
| RefSeq | NM_000316 | ||||||
| UniProt | Q03431 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p22-p21.1 | ||||||
| |||||||
| parathyroid hormone 2 receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTH2R | ||||||
| NCBI gene | 5746 | ||||||
| HGNC | 9609 | ||||||
| OMIM | 601469 | ||||||
| RefSeq | NM_005048 | ||||||
| UniProt | P49190 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q33 | ||||||
| |||||||
References
edit- ^ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
- ^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. doi:10.1152/ajprenal.1999.277.5.F665. PMID 10564229. Archived from the original on 2009-02-13. Retrieved 2007-11-01.
- ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/mend.10.5.8732687. PMID 8732687.
- ^ Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.
External links
edit- Parathyroid+Hormone+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- "Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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