Methanobrevibacter oralis is a methanogenic archaeon species considered to be a member of the human microbiota, mainly associated to the oral cavity. M. oralis is a coccobacillary shaped, single-cell, Gram-positive, non-motile microorganism of the Archaea domain of life.[1] This species has been isolated and sequenced from humans in dental plaque and in their gastrointestinal tract.[1][2] As a methanogen and a hydrogenotroph, this prokaryote can produce methane by using hydrogen and carbon dioxide as substrates through a process called methanogenesis.
| Methanobrevibacter oralis | |
|---|---|
Scientific classification 
| |
| Domain: | Archaea |
| Kingdom: | Euryarchaeota |
| Class: | Methanobacteria |
| Order: | Methanobacteriales |
| Family: | Methanobacteriaceae |
| Genus: | Methanobrevibacter |
| Species: | M. oralis
|
| Binomial name | |
| Methanobrevibacter oralis Ferrari et al. 1995
| |
Discovery and comparisons to Methanobrevibacter smithii
editOriginally isolated in 1994 from human dental plaque, Methanobrevibacter oralis has been the third most common methanogenic archaea seen in the human body, preceded by Methanobrevibacter smithii and Methanosphaera stadtmanae. This species of archaea has not been described in other species.[3] It has been seen in ancient human dental calculus, as well as in different studies of oral pathologies in different continents, from Europe, Asia, the Americas and Africa.[4][5]
The first draft genomic sequence, however, came from a strain that came from stool.[6] This species is highly phylogenetically related to M. smithii however it is not a distinct member of the human gut, instead it is most prevalent in the human oral cavity. Comparisons of their genomic sequences shows distinct gene differences between the two species that may provide some information on the niche distinction. Another difference that separates M. oralis from M. smithii is that it only utilizes hydrogen gas (H2) and carbon dioxide (CO2) for methanogenesis, while M. smithii uses those two substrates as well as formate.[7]
Implications in oral health and human microbiome
editThe major interest with M. oralis has been that it is associated with periodontal disease, with an increase in abundance seen of this archaea when compared to its abundance in healthy samples. Periodontitis is an infection caused by multiple, different anaerobic bacteria and it has been suggested that the increase of M. oralis contributes to this disease due to potential syntrophic interactions with the other members of this infection.[8][9] These syntrophic interactions include supporting microbial fermentation by consuming the hydrogen from said process. Although not currently considered a pathogen for this disease, multiple studies are looking into understanding its relation to this disease through more cultivation-independent sample sets, evolutionary studies, and immunological responses.[5][10]
Although focus has been on the oral microbiome, PCR-based and metagenomic sequencing studies have been seeing evidence of this species in human gut, brain abscess, in the respiratory tract, and appendicular abscesses. More studies need to be done to understand the implication of M. oralis in these niches.[11][12][13]
References
edit- ^ a b Ferrari, Annamaria; Brusa, Tullio; Rutili, Anna; Canzi, Enrica; Biavati, Bruno (1994-07-01). "Isolation and characterization ofMethanobrevibacter oralis sp. nov". Current Microbiology. 29 (1): 7–12. doi:10.1007/BF01570184. ISSN 1432-0991. S2CID 37098688.
- ^ Khelaifia, Saber; Garibal, Marc; Robert, Catherine; Raoult, Didier; Drancourt, Michel (2014-02-20). "Draft Genome Sequencing of Methanobrevibacter oralis Strain JMR01, Isolated from the Human Intestinal Microbiota". Genome Announcements. 2 (1): e00073–14. doi:10.1128/genomeA.00073-14. ISSN 2169-8287. PMC 3931360. PMID 24558239.
- ^ Guindo, Cheick Oumar; Davoust, Bernard; Drancourt, Michel; Grine, Ghiles (2020-12-23). "Diversity of Methanogens in Animals' Gut". Microorganisms. 9 (1): 13. doi:10.3390/microorganisms9010013. ISSN 2076-2607. PMC 7822204. PMID 33374535.
- ^ Granehäll, Lena; Huang, Kun D.; Tett, Adrian; Manghi, Paolo; Paladin, Alice; O’Sullivan, Niall; Rota-Stabelli, Omar; Segata, Nicola; Zink, Albert; Maixner, Frank (2021-09-30). "Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter". Microbiome. 9 (1): 197. doi:10.1186/s40168-021-01132-8. ISSN 2049-2618. PMC 8485483. PMID 34593021.
- ^ a b Sogodogo, Elisabeth; Doumbo, Ogobara; Aboudharam, Gérard; Kouriba, Bourema; Diawara, Ousseynou; Koita, Hapssa; Togora, Souleymane; Drancourt, Michel (2019-10-30). "First characterization of methanogens in oral cavity in Malian patients with oral cavity pathologies". BMC Oral Health. 19 (1): 232. doi:10.1186/s12903-019-0929-8. ISSN 1472-6831. PMC 6820998. PMID 31666044.
- ^ Khelaifia, Saber; Garibal, Marc; Robert, Catherine; Raoult, Didier; Drancourt, Michel (2014-02-27). "Draft Genome Sequencing of Methanobrevibacter oralis Strain JMR01, Isolated from the Human Intestinal Microbiota". Genome Announcements. 2 (1). doi:10.1128/genomeA.00073-14. ISSN 2169-8287. PMC 3931360. PMID 24558239.
- ^ Gaci, Nadia; Borrel, Guillaume; Tottey, William; O’Toole, Paul William; Brugère, Jean-François (2014-11-21). "Archaea and the human gut: New beginning of an old story". World Journal of Gastroenterology. 20 (43): 16062–16078. doi:10.3748/wjg.v20.i43.16062. ISSN 1007-9327. PMC 4239492. PMID 25473158.
- ^ Mohammadzadeh, Rokhsareh; Mahnert, Alexander; Duller, Stefanie; Moissl-Eichinger, Christine (2022-06-01). "Archaeal key-residents within the human microbiome: characteristics, interactions and involvement in health and disease". Current Opinion in Microbiology. 67: 102146. doi:10.1016/j.mib.2022.102146. ISSN 1369-5274. PMID 35427870.
- ^ Chaudhary, Prem Prashant; Conway, Patricia Lynne; Schlundt, Jørgen (2018-04-01). "Methanogens in humans: potentially beneficial or harmful for health". Applied Microbiology and Biotechnology. 102 (7): 3095–3104. doi:10.1007/s00253-018-8871-2. ISSN 1432-0614. PMID 29497795. S2CID 3605290.
- ^ Hirai, Kimito; Maeda, Hiroshi; Omori, Kazuhiro; Yamamoto, Tadashi; Kokeguchi, Susumu; Takashiba, Shogo (2013). ""Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT"". Pathogens and Disease. 68 (1): 12–19. doi:10.1111/2049-632X.12041. PMID 23620386.
- ^ Djemai, K.; Gouriet, F.; Sielezneff, I.; Mege, D.; Drancourt, M.; Grine, G. (2021-12-01). "Detection of methanogens in peri-appendicular abscesses: Report of four cases". Anaerobe. 72: 102470. doi:10.1016/j.anaerobe.2021.102470. ISSN 1075-9964. PMID 34743984.
- ^ Drancourt, Michel; Nkamga, Vanessa Demonfort; Lakhe, Ndèye Aïssatou; Régis, Jean-Marie; Dufour, Henry; Fournier, Pierre-Edouard; Bechah, Yassina; Michael Scheld, W; Raoult, Didier (2017-07-01). "Evidence of Archaeal Methanogens in Brain Abscess". Clinical Infectious Diseases. 65 (1): 1–5. doi:10.1093/cid/cix286. ISSN 1058-4838. PMID 28379309.
- ^ Koskinen, Kaisa; Pausan, Manuela R.; Perras, Alexandra K.; Beck, Michael; Bang, Corinna; Mora, Maximilian; Schilhabel, Anke; Schmitz, Ruth; Moissl-Eichinger, Christine (2017-12-29). Schleper, Christa M.; Jansson, Janet K. (eds.). "First Insights into the Diverse Human Archaeome: Specific Detection of Archaea in the Gastrointestinal Tract, Lung, and Nose and on Skin". mBio. 8 (6). doi:10.1128/mBio.00824-17. ISSN 2161-2129. PMC 5686531. PMID 29138298.
Further reading
edit- Lepp, P. W.; Brinig, M. M.; Ouverney, C. C.; Palm, K.; Armitage, G. C.; Relman, D. A. (2004). "Methanogenic Archaea and human periodontal disease". Proceedings of the National Academy of Sciences. 101 (16): 6176–6181. Bibcode:2004PNAS..101.6176L. doi:10.1073/pnas.0308766101. ISSN 0027-8424. PMC 395942. PMID 15067114.
- Horz HP, Conrads G (February 2011). "Methanogenic Archaea and oral infections — ways to unravel the black box". J Oral Microbiol. 3. doi:10.3402/jom.v3i0.5940. PMC 3086593. PMID 21541092.
- Vianna ME, Conrads G, Gomes BP, Horz HP (April 2006). "Identification and quantification of archaea involved in primary endodontic infections". J Clin Microbiol. 44 (4): 1274–82. doi:10.1128/JCM.44.4.1274-1282.2006. PMC 1448633. PMID 16597851.
- Vianna ME, Holtgraewe S, Seyfarth I, Conrads G, Horz HP (May 2008). "Quantitative analysis of three hydrogenotrophic microbial groups, methanogenic archaea, sulfate-reducing bacteria, and acetogenic bacteria, within plaque biofilms associated with human periodontal disease". J Bacteriol. 190 (10): 3779–85. doi:10.1128/JB.01861-07. PMC 2394984. PMID 18326571.
- Weyrich LS, Duchene S, Soubrier J, Arriola L, Llamas B, Breen J, Morris AG, Alt KW, Caramelli D, Dresely V, Farrell M, Farrer AG, Francken M, Gully N, Haak W, Hardy K, Harvati K, Held P, Holmes EC, Kaidonis J, Lalueza-Fox C, de la Rasilla M, Rosas A, Semal P, Soltysiak A, Townsend G, Usai D, Wahl J, Huson DH, Dobney K, Cooper A (April 2017). "Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus". Nature. 544 (7650): 357–361. doi:10.1038/nature21674. PMID 28273061.