It has been suggested that this article be merged into Propylhexedrine. (Discuss) Proposed since September 2024. |
Levopropylhexedrine (Eventin) is an adrenergic alkylamine that was used as an anorectic in Germany[1][2] and was first patented for medical use by Smith Kline & French in 1947.[3] It has also been used in the anticonvulsant preparation barbexaclone in combination with phenobarbital to offset sedation.[4][5][6] Levopropylhexedrine is the levorotatory enantiomer of propylhexedrine. The dextrorotatory counterpart is known as dextropropylhexedrine.
Clinical data | |
---|---|
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.025.678 |
Chemical and physical data | |
Formula | C10H21N |
Molar mass | 155.285 g·mol−1 |
3D model (JSmol) | |
|
Synthesis
editThe enantiopure synthesis of levopropylhexedrine may be accomplished in a two step reaction. The first step is the Wenker synthesis of the relevant aziridine. The second step is the simple catalytic hydrogenation of the propylhexedrine-aziridine.[7]
See also
editReferences
edit- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ^ Hofer R, Locker A (1958). "Über therapeutische Erfahrungen mit dem Appetitzügler Eventin" [Therapeutic experiences with the appetite depressant eventin]. Wiener Medizinische Wochenschrift (in German). 108 (14): 304–6. PMID 13558159.
- ^ US 2454746 Cyclohexylalkylamines
- ^ Oliveira C, Fernandes I, De Lima JM, Musse R (1977). "Ensaio clínico com barbexaclone nas epilepsias" [Clinical trial with barbexaclone in epilepsies]. Arquivos de Neuro-Psiquiatria (in Portuguese). 35 (1): 68–72. doi:10.1590/s0004-282x1977000100008. PMID 14606.
- ^ Iven H, Feldbusch E (1983). "Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse". Naunyn-Schmiedeberg's Archives of Pharmacology. 324 (2): 153–9. doi:10.1007/bf00497022. PMID 6139756. S2CID 25628466.
- ^ Seyffart, G. (1991). Drug dosage in renal insufficiency. Boston: Kluwer Academic Publishers. ISBN 0-7923-0964-2.
- ^ Haberl, R. (1958-11-01). "Über eine neue Bildungsweise des 1,2-Dimethyl-3-phenyl-äthylenimins". Monatshefte für Chemie und verwandte Teile anderer Wissenschaften (in German). 89 (6): 814–816. doi:10.1007/BF00902540. ISSN 1434-4475.