It's the End of the World

The episode opens with a voice-over narration from Meredith Grey (Ellen Pompeo) about the inevitability of death and the importance of pursuing one's dreams before it's too late.

In a dream sequence, George O'Malley (T. R. Knight) imagines himself in the shower with Izzie Stevens (Katherine Heigl), Cristina Yang (Sandra Oh) and Meredith Grey (Ellen Pompeo). George wakes up from the dream only to find Meredith refusing to get out of bed for work, convinced she will die that day. Despite George and Izzie’s efforts to convince her otherwise, it takes Cristina joining in to finally get Meredith out of bed and to the hospital.

At the hospital, Meredith's ominous premonition seems to gain credibility. Dr. Miranda Bailey (Chandra Wilson) returns to the hospital to have her baby, alone, as her husband is on his way by car. Simultaneously, a severely injured male trauma patient and his panicked, screaming wife are brought in by paramedics. One of the paramedics, Hannah Davies (Christina Ricci), has her hand inside the man's chest cavity to stop the bleeding. Dr. Preston Burke (Isaiah Washington) quickly takes charge of the case, and Alex Karev (Justin Chambers) is assigned to calm down the hysterical wife, which he successfully does by yelling back at her, shocking her into composure.

Things take a dangerous turn when it is discovered that Hannah’s hand isn’t the only thing inside the patient's chest. The patient has a piece of unexploded ammunition lodged in him, having accidentally fired a homemade bazooka. The hospital goes into Code Black for a bomb threat, shutting down most of the surgical wing—except for the operation that is already in progress: Derek Shepherd (Patrick Dempsey) and Cristina are operating on the brain of a man who, unbeknownst to them at first, is Tucker Jones (Cress Williams), Bailey's husband, who was involved in a car accident while rushing to the hospital to be with her.

Bailey refuses to have her baby until her husband arrives, unaware that he is already in surgery. The interns discover this when George calls Bailey's husband’s phone at her request, and Izzie finds the phone in the man's belongings. They decide not to tell Bailey until Derek has more information about his prognosis.

Meanwhile, the bomb squad, led by Dylan Young (Kyle Chandler), arrives and works to contain the situation. They want to clear out the ORs of any non-essential personnel, but Derek, Cristina, and Meredith refuse to leave. Elsewhere, Izzie and George talk about feeling like "watchers" compared to Cristina and Meredith, who are "doers". Izzie, determined to act, decides to reignite her relationship with Alex, and they hook up in the supply closet.

Richard Webber (James Pickens Jr.), struggling to maintain order amidst the chaos, does his best to keep the hospital functioning despite the escalating danger. In the surgical wing, the anesthesiologist, without warning, quietly trains Hannah on how to provide airflow for the patient and then flees, leaving her alone with the patient and the bomb. Meredith finds Hannah on the verge of a breakdown, about to pull her hand out, which would detonate the bomb and kill everyone in the room. Despite Meredith’s attempts to calm her down, Hannah panics and pulls her hand out, fleeing the scene—leaving Meredith to step in and place her own hand on the bomb to keep the patient and everyone else safe.

The episode's title refers to the song "It's the End of the World as We Know It (And I Feel Fine)" by R.E.M., whose lead singer, Michael Stipe, collaborated with Coldplay frontman Chris Martin for a cover of the Joseph Arthur song "In The Sun", which closes the episode.^[3]

• "Dead Streets" - The Monotypes
• "Miniature Disasters" - KT Tunstall
• "Kaboom!" - Ursula 1000
• "In the Sun" - Michael Stipe and Chris Martin

Wetpaint named it in December 2011 one of the 5 best episodes of Grey's Anatomy along with the second part "As We Know It".^[4]

• "It's the End of the World" at IMDb