EIF5AP1

Article
Talk

Eukaryotic translation initiation factor 5A pseudogene 1, also known as EIF5AP1, is a human gene.^[3]

EIF5AL1

Identifiers

EIF5AL1, EIF5AP1, bA342M3.3, eukaryotic translation initiation factor 5A-like 1, EIF5A, eIF-5A, eIF-5A1, eIF-4D, eIF-5A-1, eukaryotic translation initiation factor 5A like 1

External IDs

HomoloGene: 100947; GeneCards: EIF5AL1; OMA:EIF5AL1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q22.3	Start	79,512,533 bp^[1]
Band	10q22.3	End	79,516,440 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

left testis

right testis

thymus

mucosa of transverse colon

stromal cell of endometrium

bone marrow cells

muscle of thigh

liver

gastrocnemius muscle

n/a

More reference expression data

n/a

Gene ontology
Molecular function	translation elongation factor activity RNA binding ribosome binding
Cellular component	nuclear pore endoplasmic reticulum membrane nucleus membrane cytoplasm endoplasmic reticulum
Biological process	protein transport translational frameshifting positive regulation of translational elongation translational elongation mRNA transport protein biosynthesis positive regulation of translational termination
Sources:Amigo / QuickGO

Species

Human

Mouse


143244


n/a


ENSG00000253626


n/a


Q6IS14


n/a

RefSeq (mRNA)


NM_001099692


n/a

RefSeq (protein)


NP_001093162


n/a

Location (UCSC)

Chr 10: 79.51 – 79.52 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EIF5AP1 eukaryotic translation initiation factor 5A pseudogene 1".

Further reading

Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–618. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.
Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells". FEBS J. 273 (6): 1102–1114. doi:10.1111/j.1742-4658.2006.05135.x. PMC 4406228. PMID 16519677.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Facchiano AM, Stiuso P, Chiusano ML, et al. (2002). "Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A)". Protein Eng. 14 (11): 881–890. doi:10.1093/protein/14.11.881. PMID 11742107.
Lipowsky G, Bischoff FR, Schwarzmaier P, et al. (2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–4371. doi:10.1093/emboj/19.16.4362. PMC 302028. PMID 10944119.
Ruhl M, Himmelspach M, Bahr GM, et al. (1994). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation". J. Cell Biol. 123 (6 Pt 1): 1309–1320. doi:10.1083/jcb.123.6.1309. PMC 2290910. PMID 8253832.
Steinkasserer A, Jones T, Sheer D, et al. (1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.
Koettnitz K, Wöhl T, Kappel B, et al. (1995). "Identification of a new member of the human eIF-5A gene family". Gene. 159 (2): 283–284. doi:10.1016/0378-1119(95)00136-T. PMID 7622067.
Koettnitz K, Kappel B, Baumruker T, et al. (1994). "The genomic structure encoding human initiation factor eIF-5A". Gene. 144 (2): 249–252. doi:10.1016/0378-1119(94)90385-9. PMID 7545941.
Park MH, Liu TY, Neece SH, Swiggard WJ (1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue". J. Biol. Chem. 261 (31): 14515–9. doi:10.1016/S0021-9258(18)66899-1. PMID 3095320.
Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein". J. Biol. Chem. 264 (3): 1578–83. doi:10.1016/S0021-9258(18)94226-2. PMID 2492279.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.

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