Daniela Bargellini Rhodes FRS[1] (born 1946) is an Italian structural and molecular biologist. She was a senior scientist at the Laboratory of Molecular Biology in Cambridge, England,[4] where she worked, and later studied for her PhD[5] under the supervision of Nobel laureate Aaron Klug. Continuing her work under the tutelage of Aaron Klug at Cambridge, she was appointed group leader in 1983, obtained tenure in 1987 and was promoted to senior scientist in 1994 (equivalent to full professor). Subsequently, she served as director of studies between 2003 and 2006. She has also been visiting professor at both "La Sapienza" in Rome, Italy and the Rockefeller University in NY, USA.[6][7][8][9][10]
Daniela Rhodes | |
|---|---|
 Daniela Rhodes at the Laboratory of Molecular Biology | |
| Alma mater | University of Cambridge |
| Awards | FRS (2007);[1] The WLA Prize in Life Science or Medicine (2023) |
| Scientific career | |
| Institutions | |
| Thesis | The helical periodicity of DNA in solution and in chromatin (1982) |
| Doctoral advisor | Aaron Klug[3] |
| Website | www2 |
Career and research
editDaniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as zinc-fingers and nuclear hormone receptors. She has provided some of the first structural information on telomeric proteins, such as yeast Rap1p and human TRF1 and TRF2 and their complexes with DNA. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the nucleosome core particle, has worked on transcriptionally active chromatin and more recently on the higher order 30nm structure of chromatin.[4] Her research continues to focus on understanding how the structure of chromatin is involved in transcriptional regulation and how telomeres are involved in preserving chromosome integrity.[11]
She joined the School of Biological Sciences at Nanyang Technological University (NTU), in Singapore, as professor in September 2011[12] and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.[13] In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.
Daniela left NTU in 2020 and is an Emeritus Scientist at the Laboratory of Molecular Biology.
Awards and honours
edit- Laureate of the 2023 World Laureates Association Prize in Life Science or Medicine (With Timothy J. Richmond and Karolin Luger)[14]
- Elected a Fellow of the Royal Society (FRS) in 2007[1]
- Elected member of EMBO as of 1996.
- Elected member of Academia Europaea as of 2011.
- She is a Fellow of Clare Hall, Cambridge.
- Asteroid 80008 Danielarhodes, discovered by Italian astronomers Luciano Tesi and Andrea Boattini in 1999, was named in her honor.[15] The official naming citation was published by the Minor Planet Center on 10 December 2011 (M.P.C. 77507).[16]
References
edit- ^ a b c "Professor Daniela Rhodes FRS". London: Royal Society. Archived from the original on 17 November 2015.
- ^ "Emeritus Scientist: Daniela Rhodes". Laboratory of Molecular Biology. Archived from the original on 8 December 2015.
- ^ Rhodes, D. (2002). "Climbing mountains: A profile of Max Perutz 1914–2002: a life in science". EMBO Reports. 3 (5): 393–395. doi:10.1093/embo-reports/kvf103. ISSN 1469-221X. PMC 1084116. PMID 11991939.
- ^ a b "International Conference – Speakers – Daniela Rhodes". SET-Routes. 1 April 2008. Archived from the original on 3 March 2016. Retrieved 2 January 2014.
- ^ Rhodes, Daniela (1982). The helical periodicity of DNA in solution and in chromatin (PhD thesis). University of Cambridge. OCLC 556524059.
- ^ "Analysis of sequence-specific DNA-binging proteins", Protein function: a practical approach, Editor Thomas E. Creighton, Oxford University Press, 1997, ISBN 978-0-19-963615-0
- ^ "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression", Structural biology and functional genomics, Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, ISBN 978-0-7923-5781-0
- ^ "Telomeric DNA Recognition", RNA biochemistry and biotechnology, Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, ISBN 978-0-7923-5861-9
- ^ "Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" "Daniela Rhodes, PhD – Biochemistry and Biophysics". University of North Carolina School of Medicine. 22 April 2008. Archived from the original on 26 September 2012. Retrieved 2 January 2014.
- ^ Daniela Rhodes's profile at Scientific Commons
- ^ LMB Web-page Archived 30 March 2009 at the Wayback Machine
- ^ "Academic Profile: Professor Daniela Rhodes". Nanyang Technological University. 4 August 2009. Retrieved 2 January 2014.
- ^ "Academic Profile: Professor Daniela Rhodes". LKC School of Medicine. 4 August 2009. Archived from the original on 3 April 2014. Retrieved 3 April 2014.
- ^ "Laureates of the 2023 WLA Prize Announced". The WLA Prize.
- ^ "(80008) Danielarhodes". Minor Planet Center. Retrieved 15 January 2020.
- ^ "MPC/MPO/MPS Archive". Minor Planet Center. Retrieved 15 January 2020.