DDOST

DDOST
Identifiers
Aliases	DDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDs	OMIM: 602202; MGI: 1194508; HomoloGene: 3821; GeneCards: DDOST; OMA:DDOST - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,661,544 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,039,939 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; stromal cell of endometrium; ; body of pancreas; ; caput epididymis; ; islet of Langerhans; ; rectum; ; smooth muscle tissue; ; placenta; ; beta cell; ; spleen;
	Top expressed in
	parotid gland; ; lacrimal gland; ; seminal vesicula; ; gastrula; ; dermis; ; islet of Langerhans; ; molar; ; stroma of bone marrow; ; vestibular sensory epithelium; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein binding; oligosaccharyl transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; oligosaccharyltransferase complex; plasma membrane; azurophil granule membrane; protein-containing complex;
Biological process	response to cytokine; protein N-linked glycosylation via asparagine; protein glycosylation; protein N-linked glycosylation; T cell activation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1650
	13200
	ENSG00000244038
	ENSMUSG00000028757
	P39656
	O54734
	NM_005216
	NM_007838
	NP_005207
	NP_031864
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.^[5]^[6]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.
^ ^a ^b "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

Kumar V, Korza G, Heinemann FS, Ozols J (1995). "Human oligosaccharyltransferase: isolation, characterization, and the complete amino acid sequence of 50-kDa subunit". Arch. Biochem. Biophys. 320 (2): 217–23. doi:10.1016/0003-9861(95)90003-9. PMID 7625827.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Stitt AW, He C, Vlassara H (1999). "Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells". Biochem. Biophys. Res. Commun. 256 (3): 549–56. doi:10.1006/bbrc.1999.0291. PMID 10080935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lu C, He JC, Cai W, et al. (2004). "Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells". Proc. Natl. Acad. Sci. U.S.A. 101 (32): 11767–72. Bibcode:2004PNAS..10111767L. doi:10.1073/pnas.0401588101. PMC 511050. PMID 15289604.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367678-5] Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.

[entrez-6] "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

[5]

[6]

[1]

[2]

[3]

[4]

DDOST

References

Further reading