CABIN1

CABIN1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1N6J
Identifiers
Aliases	CABIN1, CAIN, PPP3IN, KB-318B8.7, calcineurin binding protein 1
External IDs	OMIM: 604251; MGI: 1298375; HomoloGene: 49307; GeneCards: CABIN1; OMA:CABIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,178,628 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,600,175 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; granulocyte; ; right uterine tube; ; right lobe of thyroid gland; ; right coronary artery; ; apex of heart; ; left lobe of thyroid gland; ; popliteal artery; ; tibial arteries;
	Top expressed in
	zygote; ; granulocyte; ; secondary oocyte; ; primary visual cortex; ; ventricular zone; ; superior frontal gyrus; ; neural layer of retina; ; yolk sac; ; tail of embryo; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity; nucleosome binding;
Cellular component	aggresome; nucleus; nucleoplasm; cytosol;
Biological process	cell surface receptor signaling pathway; negative regulation of phosphoprotein phosphatase activity; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23523
	104248
	ENSG00000099991; ENSG00000281670
	ENSMUSG00000020196
	Q9Y6J0
	n/a
	NM_001199281; NM_001201429; NM_012295
	NM_172549
	NP_001186210; NP_001188358; NP_036427
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.^[5]^[6]^[7]

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.^[7]

Interactions

CABIN1 has been shown to interact with:

References

^ ^a ^b ^c ENSG00000281670 GRCh38: Ensembl release 89: ENSG00000099991, ENSG00000281670 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020196 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
^ ^a ^b "Entrez Gene: CABIN1 calcineurin binding protein 1".
^ Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
^ Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
^ ^a ^b Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
^ ^a ^b Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

External links

Human CABIN1 genome location and CABIN1 gene details page in the UCSC Genome Browser.
Human KB-318B8.7 genome location and KB-318B8.7 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000281670 GRCh38: Ensembl release 89: ENSG00000099991, ENSG00000281670 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020196 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9655484-5] Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.

[pmid9205841-6] Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.

[entrez-7] "Entrez Gene: CABIN1 calcineurin binding protein 1".

[pmid10931822-8] Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.

[pmid12700764-9] Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.

[pmid10531067-10] Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.

[pmid10933397-11] Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

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CABIN1

Contents

Function

Interactions

References

Further reading

External links