Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene .[ 5] [ 6] [ 7]
BDP1 Identifiers Aliases BDP1 External IDs OMIM : 607012 ; MGI : 1347077 ; HomoloGene : 34582 ; GeneCards : BDP1 ; OMA :BDP1 - orthologs Wikidata
TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis , resulting in its release from chromatin and suppression of polymerase III transcription.[ 7]
^ a b c ENSG00000273873, ENSG00000145734 GRCh38: Ensembl release 89: ENSG00000274803, ENSG00000273873, ENSG00000145734 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049658 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (6): 347–55. doi :10.1093/dnares/7.6.347 PMID 11214970 . ^ Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters" . Genes Dev . 14 (20): 2650–63. doi :10.1101/gad.836400 . PMC 316990 PMID 11040218 . ^ a b "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB" .
Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2" . J. Biol. Chem . 272 (23): 14755–61. doi :10.1074/jbc.272.23.14755 PMID 9169441 . Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation" . Genes Dev . 11 (10): 1315–26. doi :10.1101/gad.11.10.1315 PMID 9171375 . Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (5): 337–45. doi :10.1093/dnares/6.5.337 PMID 10574462 . Kelter AR, Herchenbach J, Wirth B (2001). "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1". Genomics . 70 (3): 315–26. doi :10.1006/geno.2000.6396 . PMID 11161782 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hu P, Wu S, Hernandez N (2003). "A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2" . Mol. Cell . 12 (3): 699–709. doi :10.1016/j.molcel.2003.08.011 PMID 14527415 . Fairley JA, Scott PH, White RJ (2003). "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo" . EMBO J . 22 (21): 5841–50. doi :10.1093/emboj/cdg544 . PMC 275401 PMID 14592981 . Weser S, Gruber C, Hafner HM, et al. (2004). "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity" . J. Biol. Chem . 279 (26): 27022–9. doi :10.1074/jbc.M312790200 PMID 15096501 . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Hu P, Samudre K, Wu S, et al. (2004). "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression" . Mol. Cell . 16 (1): 81–92. doi :10.1016/j.molcel.2004.09.008 PMID 15469824 . Schoenen F, Wirth B (2006). "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB". Biol. Chem . 387 (3): 277–84. doi :10.1515/BC.2006.037 . PMID 16542149 . S2CID 28560128 . Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases" . Mol. Cell . 26 (3): 367–79. doi :10.1016/j.molcel.2007.03.021 PMID 17499043 .
