Talk:Immune tolerance

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I am planning to significantly edit this page in the coming weeks. I will include a formal definition, history, sections on central and peripheral tolerance (with links to the appropriate Wikipedia articles), examples of immune tolerance in physiology and medicine, and current thoughts on the evolution and tradeoffs of immune tolerance. Please let me know if you have any comments on that right now before I begin my edits. KMKc (talk) 21:19, 10 December 2013 (UTC)[reply]

On merge with central tolerance: I don't think so. At the moment it looks attractive simply because both are stubs. But if there was a decent coverage of this topic then immune tolerance would be a massive article (with 30 000 peer-reviewed articles written on it, the topic is huge and varied). I think immune tolerance should basically remain an overview article, with links to the specific forms of immune tolerance, such as central tolerance, negative selection, regulatory T cell conversion, oral tolerance, etc etc). Sad mouse 16:09, 13 December 2006 (UTC)[reply]

I agree that the two topics shouldn't be merged. As I understand it, immunological tolerance (immune system not attacking cells, foreign or self - can be pathological) is a broader topic than central tolerance (immune system not attacking self cells - not pathological but rather necessary), and encompasses central tolerance, but isn't the same as it. 24.205.81.199 00:56, 3 February 2007 (UTC)[reply]

My view is that clonal deletion is the main mechanism for removal of nearly mature self reactive lymphocytes and operates by a different mechanism to that seen in the establishment of peripheral tolerance where a mature B cell has reacted inappropriately to self. The key to understanding autoimmune disease is held by many authors to lie in a failure to establish peripheral tolerance. A cure cannot be far behind the finding of this key. For this reason I would like to see peripheral tolerance kept under a separate page (with suitable cross reference links) Dioscoredes 21:09, 8 February 2007 (UTC)dioscoredes[reply]

Central tolerance should become a subcategory of immune tolerance. Central tolerance refers to identification of self and not attacking it. Immune tolerance includes central tolerance, refers to any non-response to a given antigen. Jcforge 14:53, 21 February 2007 (UTC)[reply]

The first sentence could (and should) first give a definition, before diving into the subject of distinctions (between natural and induced tolerance).

The sentence reads (at the time of writing this on 2009-09-24): "... can be either (a) 'natural' or 'self tolerance', where the body does not mount an immune response to self antigens, or (b) 'induced tolerance', where tolerance to external antigens can be created by manipulating the immune system.".

Jacosi (talk) 11:13, 24 September 2009 (UTC)[reply]

Hi, I was adding some more reliable sources to this page and I came across some more information that could be added to expand this page. Just a suggestion, but I think it would be beneficial to add more information on the topic of peripheral tolerance. I found a couple sources that include this topic and have listed them below:

Immunology: essential and fundamental (2005) by Sulabha Pathak, Urmi Palan ISBN 1578083788

Antigen presenting cells: from mechanisms to drug development (2005) By Harald Kropshofer, Anne B. Vogt ISBN 3527311084

Immunology: a short course By Richard Coico, Geoffrey Sunshine page 186 ISBN 0470081589

--Naf24 (talk) 22:01, 12 September 2011 (UTC)[reply]